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Ligand UDP-MurNAc-Ala-D-Glu-Lys

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for UDP-MurNAc-Ala-D-Glu-Lys

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.10

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine

743956, 744222, 677589, 680459

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In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.7

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

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4c12, 3D-view

6.3.2.7

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

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4c13, 3D-view

6.3.2.7

2 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.8.13

UDP-MurNAc-Ala-D-Glu-Lys + undecaprenyl phosphate = UMP + MurNAc-Ala-D-Glu-Lys-diphosphoundecaprenol

645333

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6.3.2.10

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine

677589, 743956, 744222, 680459

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Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.7

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

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4c12, 3D-view

6.3.2.7

ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

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4c13, 3D-view

6.3.2.7

2 entries

6.3.2.B2

ATP + L-alanyl-gamma-D-glutamyl-L-lysine + UDP-MurNAc = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine

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3D Structure of Enzyme-Ligand-Complex (PDB) (8 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (8 entries)

EC NUMBER

ENZYME 3D STRUCTURE

6.3.2.7

4c12, 3D-view

6.3.2.7

4c13, 3D-view

6.3.2.7

4c12, 3D-view

6.3.2.7

4c13, 3D-view

6.3.2.7

4c12, 3D-view

6.3.2.7

4c13, 3D-view

6.3.2.7

4c12, 3D-view

6.3.2.7

4c13, 3D-view

6.3.2.7

8 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.8.13

0.18

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pH 7.8, 37°C

645333

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

645333

4208473

On the specificity of phospho-N-acetylmuramyl-pentapeptide translocase. The peptide subunit of uridine diphosphate-N-actylmuramyl-pentapeptide

1974

Hammes, W.P.; Neuhaus, F.C.

J. Biol. Chem.

249

3140-3150

677589

16377691

Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF

2006

Baum, E.Z.; Crespo-Carbone, S.M.; Abbanat, D.; Foleno, B.; Maden, A.; Goldschmidt, R.; Bush, K.

Antimicrob. Agents Chemother.

50

230-236

680459

16547042

Role of murF in cell wall biosynthesis: isolation and characterization of a murF conditional mutant of Staphylococcus aureus

2006

Sobral, R.G.; Ludovice, A.M.; de Lencastre, H.; Tomasz, A.

J. Bacteriol.

188

2543-2553

743956

25005102

Purification, crystallization and preliminary X-ray crystallographic analysis of the UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (MurF) from Acinetobacter baumannii

2014

An, Y.J.; Jeong, C.S.; Yu, J.H.; Chung, K.M.; Cha, S.S.

Acta Crystallogr. Sect. F

70

976-978

744222

24978312

ATP-binding mode including a carbamoylated lysine and two Mg(2+) ions, and substrate-binding mode in Acinetobacter baumannii MurF

2014

Cha, S.S.; An, Y.J.; Jeong, C.S.; Yu, J.H.; Chung, K.M.

Biochem. Biophys. Res. Commun.

450

1045-1050

Links to other databases for UDP-MurNAc-Ala-D-Glu-Lys

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Show Links (1 entry)

ChEBI

PubChem

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