Ligand protein C-terminal S-farnesyl-L-cysteine methyl ester

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Basic Ligand Information

Molecular Structure

C₂₃H₃₆N₃O₄R₃S

protein C-terminal S-farnesyl-L-cysteine methyl ester

KEGG

Biosynthesis of secondary metabolites, Terpenoid backbone biosynthesis

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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2.1.1.100

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester

0, 485024, 485022, 485020

Product in Enzyme-catalyzed Reactions (1 result)

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2.1.1.100

S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester

485045, 0, 485025, 485039, 485042, 485024, 485020, 485022, 485021, 485031, 485027, 485041

Enzyme Kinetic Parameters

References & Links

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Show Reference (11 entries)

485020

3290900

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases [published erratum appears in Proc Natl Acad Sci U S A 1988 Oct;85(20):7556]

1988

Clarke, S.; Vogel, J.P.; Deschenes, R.J.; Stock, J.

Proc. Natl. Acad. Sci. USA

4643-4647

485021

2398053

Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate

1990

Stephenson, R.C.; Clarke, S.

J. Biol. Chem.

265

16248-16254

485022

2050108

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins

1991

Hrycyna, C.A.; Sapperstein, S.K.; Clarke, S.; Michaelis, S.

EMBO J.

1699-1709