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Ligand lipid-linked oligosaccharide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

LITERATURE

REACTION DIAGRAM

PROVEN IN VIVO REACTION

ENZYME 3D STRUCTURE

2.4.99.18

488513, 488495, 488500, 488501, 488509, 488514, 488510

lipid-linked oligosaccharide + unfolded nascent polypeptide chain = ?

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Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

LITERATURE

REACTION DIAGRAM

REACTION

ENZYME 3D STRUCTURE

2.4.1.131

638571

GDP-mannose + lipid-linked Manalpha(1-3)Manbeta-GlcNAcbeta-GlcNAc = GDP + lipid-linked Manalpha(1-2)Manalpha(1-2)Manalpha(1-3)(Manalpha(1-6))Manbeta-GlcNAcbeta-GlcNAc

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2.4.99.18

488513, 488495, 488500, 488501, 488509, 488514, 488510

lipid-linked oligosaccharide + unfolded nascent polypeptide chain = ?

-

2.4.99.21

735172

lipid-linked oligosaccharide + [peptide]-L-asparagine = lipid + a glycopeptide with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine

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Enzyme Kinetic Parameters

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

488495

3297152

Oligosaccharyl transferase: the central enzyme in the pathway of glycoprotein assembly

1987

Kaplan, H.A.; Welply, J.K.; Lennarz, W.J.

Biochim. Biophys. Acta

906

161-173

488500

4039727

Active site-directed photoaffinity labeling and partial characterization of oligosaccharyltransferase

1985

Welply, J.K.; Shenbagamurthi, P.; Naider, F.; Park, H.R.; Lennarz, W.J.

J. Biol. Chem.

260

6459-6465

488501

1555242

Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein

1992

Kelleher, D.J.; Kreibich, G.; Gilmore, R.

Cell

69

55-65

488509

9144178

DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase

1997

Kelleher, D.J.; Gilmore, R.

Proc. Natl. Acad. Sci. USA

94

4994-4999

488510

9015380

A dual affinity tag on the 64-kDa Nlt1p subunit allows the rapid characterization of mutant yeast oligosaccharyl transferase complexes

1997

Pathak, R.; Imperiali, B.

Arch. Biochem. Biophys.

338

1-6

488513

9878773

The oligosaccharyltransferase complex from yeast

1999

Knauer, R.; Lehle, L.

Biochim. Biophys. Acta

1426

259-273

488514

11470266

Oligosaccharyltransferase is highly specific for the hydroxy amino acid in Asn-Xaa-Thr/Ser

2001

Breuer, W.; Klein, R.A.; Hardt, B.; Bartoschek, A.; Bause, E.

FEBS Lett.

501

106-110

638571

6698009

Solubilization of mannosyltransferase activities for the biosynthesis of mammary glycoproteins. Elongation of tetrasaccharide-lipid to heptasaccharide-lipid by a solubilized enzyme preparation

1984

Prakash, C.; Katial, A.; Kang, M.S.; Vijay, I.K.

Eur. J. Biochem.

139

87-93

735172

24127570

Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation

2013

Matsumoto, S.; Shimada, A.; Nyirenda, J.; Igura, M.; Kawano, Y.; Kohda, D.

Proc. Natl. Acad. Sci. USA

110

17868-17873

Links to other databases for lipid-linked oligosaccharide

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Show Links (1 entry)