Ligand 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine

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Basic Ligand Information

Molecular Structure
Picture of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H29NO7PR
1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
BKRHDNIDITYIPN-BVSLBCMMSA-N
Synonyms:
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-alkyl-2-acetyl-sn-glycerol-3-phosphocholine, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, 2-acetyl-1-alkyl-6-phosphocholine, 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine, 2-acetyl-1-O-alkyl-sn-glycero-3-phosphocholine, PAF, platelet-activating factor, platelet activating factor

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
platelet activating factor + H2O = ?
show the reaction diagram
-
platelet-activating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol = CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
platelet activating factor + H2O = platelet activating factor + a carboxylate
show the reaction diagram
-
platelet-activating factor + H2O = 1-O-alkyl-2-acetyl-sn-glycerol + choline phosphate
show the reaction diagram
-
platelet activating factor + H2O = ?
show the reaction diagram
-
platelet-activating factor + H2O = ? + choline
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CDP-choline + 1-O-alkyl-2-acetyl-sn-glycerol = CMP + 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine
show the reaction diagram
-
-
platelet activating factor + H2O = platelet activating factor + a carboxylate
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibition in presence of digitonin, stimulation in absence of digitonin within a certain concentration range
-
half-maximal activation at 22.4 mol%
-
requirement, agonist, beta-adrenergic receptor as substrate
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induces release of enzyme from neutrophils
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i.e. 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, induces MMP-9 enzyme expression, and increases enzyme content and activity
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
irreversible inhibition dependent of both 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and enzyme concentration
-
inhibition in presence of digitonin, stimulation in absence of digitonin within a certain concentration range
-
competitive
-
competitive
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hydrolysis of sphingomyelin
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Enzyme Kinetic Parameters

KM Value (23 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.042
-
-
0.0136
-
-

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine

ChEBI
PubChem
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PubChem