Ligand Phe-Leu

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Basic Ligand Information

Molecular Structure
Picture of Phe-Leu (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C15H22N2O3
Phe-Leu
ASBJGPTTYPEMLP-UWTATZPHSA-N
Synonyms:
L-Phe-L-Leu, L-phenylalanyl-L-leucine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Phe-Leu + H2O = Phe + Leu
show the reaction diagram
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L-Phe-L-Leu + H2O = L-Phe + L-Leu
show the reaction diagram
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Phe-Leu + H2O = Phe + Leu
show the reaction diagram
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Phe-Leu + H2O = Phe + Leu
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
Leu-Leu-Glu-Phe-Leu + H2O = Leu-Leu-Glu + Phe-Leu
show the reaction diagram
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Leu-Leu-Pro-Glu-Phe-Leu + H2O = Leu-Leu-Pro-Glu + Phe-Leu
show the reaction diagram
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Phe-Leu-Ala-Ala + H2O = Phe-Leu + Ala-Ala
show the reaction diagram
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Gly-L-Phe-L-Leu-Gly-L-Phe-L-Leu + H2O = Gly-L-Phe-L-Leu-Gly + L-Phe-L-Leu
show the reaction diagram
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Gly-Phe-Leu + H2O = Phe-Leu + Gly-Phe + Gly + Leu
show the reaction diagram
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Tyr-Gly-Gly-Phe-Leu + H2O = Tyr-Gly-Gly + Phe-Leu
show the reaction diagram
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ATP + L-phenylalanine + L-leucine = ADP + phosphate + L-phenylalanyl-L-leucine
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
58% inhibition at 1 mM
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IC50: 0.0136 mM, non-competitive
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Enzyme Kinetic Parameters

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.4
-
at pH 7.5 and 25°C, with furylacryloyl-glycyl-L-leucyl-L-alanine as substrate

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0136
-
IC50: 0.0136 mM, non-competitive

References & Links

Links to other databases for Phe-Leu

ChEBI
PubChem
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PubChem