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Ligand fraxetin Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 0 H8 O5
fraxetin
HAVWRBANWNTOJX-UHFFFAOYSA-N
Related pathways
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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fraxetin + [reduced NADPH-hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH-hemoprotein reductase] + H2O
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2
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Substrate in Enzyme-catalyzed Reactions (1 result)
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fraxetin + [reduced NADPH-hemoprotein reductase] + O2 = sideretin (reduced form) + [oxidized NADPH-hemoprotein reductase] + H2O
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Product in Enzyme-catalyzed Reactions (2 results)
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isoscopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2
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scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2
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Activator in Enzyme-catalyzed Reactions (1 result)
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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polymorphonuclear leukocyte
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19.2% inhibition at 0.01 mg/ml
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Enzyme Kinetic Parameters
References & Links Literature References (5)
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Effect of hydroxylated and methoxylated coumarins on the regulatory properties of phenylalanine ammonia-lyase from Citrus sinensis
1990
Dubery, I.A.
Phytochemistry
29
2107-2108
Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase/cyclooxygenase
2005
Schneider, I.; Bucar, F.
Phytother. Res.
19
81-102
Biosynthesis of redox-active metabolites in response to iron deficiency in plants
2018
Rajniak, J.; Giehl, R.; Chang, E.; Murgia, I.; Von Wiren, N.; Sattely, E.
Nat. Chem. Biol.
14
442-450
IRONMAN tunes responses to iron deficiency in concert with environmental pH
2021
Gautam, C.K.; Tsai, H.H.; Schmidt, W.
Plant Physiol.
187
1728-1745
Dual inhibition of HIV-1 and cathepsin L proteases by Sarcandra glabra
2022
Pan, B.; Li, S.; Xiao, J.; Yang, X.; Xie, S.; Zhou, Y.; Yang, J.; Wei, Y.
Molecules
27
5552
Links to other databases for fraxetin