Ligand alpha-cyclodextrin

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Basic Ligand Information

Molecular Structure
Picture of alpha-cyclodextrin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C36H60O30
alpha-cyclodextrin
HFHDHCJBZVLPGP-RWMJIURBSA-N
Synonyms:
alpha-cyclomaltodextrin, cyclohexaamylose, cyclomaltohexaose, cyclomaltohexose, Schardinger dextrin
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-cyclodextrin + H2O = maltose + D-glucose
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-(1-6)-glucosyl cyclohexaamylose + H2O = cyclohexaamylose + D-glucose
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (70 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dodecyl-beta-maltoside + alpha-cyclodextrin = dodecyl-beta-maltooctaoside + ?
show the reaction diagram
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ATP + alpha-cyclodextrin + H2O = AMP + phospho-alpha-cyclodextrin + phosphate
show the reaction diagram
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alpha-cyclomaltodextrin + H2O = maltose + D-glucose
show the reaction diagram
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alpha-cyclodextrin + H2O = alpha-D-glucose
show the reaction diagram
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alpha-cyclodextrin + H2O = ?
show the reaction diagram
alpha-cyclodextrin + H2O = maltose + D-glucose
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (48 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-cyclodextrin + H2O = alpha-cyclodextrin + beta-D-glucose
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates GDE in liver
-
slight stimulation of activity with maltose as substrate
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20 mM: 2.3fold activation
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10 mM, activity is enhanced by 23%
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11% increased activity at 1 mM
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Inhibitor in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
18% residual activity at a substrate/cyclodextrin molar ratio of 0.5
-
inhibition 25%
-
competitive inhibitor, 0.25%
-
moderate inhibition by 10 mM, 30°C, 1 h
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alpha-Schardinger dextrin, debranching enzyme, competitive inhibitor
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3D Structure of Enzyme-Ligand-Complex (PDB) (16 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (24 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.09
-
pH 3.5, 95°C
11.9
-
pH 5.0, 70°C, wild-type enzyme

KM Value (41 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.43
-
pH and temperature not specified in the publication
0.25
-
pH 3.5, 95°C

Ki Value (5 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
47.1
-
with respect to glycogen
0.01255
-
at pH 6.5 and 50°C
1.63
-
pH 9, 50°C, 0.25%

References & Links

Links to other databases for alpha-cyclodextrin

ChEBI
PubChem
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PubChem