Ligand iodomethane

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Basic Ligand Information

Molecular Structure
Picture of iodomethane (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH3I
iodomethane
INQOMBQAUSQDDS-UHFFFAOYSA-N
Synonyms:
1-iodomethane, CH3I, methyl iodide

Show all pahtways known for Show all pathways known for iodomethane

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CH3I + CO + HS-CoA = CH3-CO-S-CoA + HI
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + iodide = S-adenosyl-L-homocysteine + methyl iodide
show the reaction diagram
-
-
S-adenosyl-L-methionine + iodide = S-adenosyl-L-homocysteine + iodomethane
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
noncompetitive
-
can directly alkylate the active site of the enzyme, the agent can increase the effectiveness of environmental and endogenously produced alkylating carcinogens in producing the mutagenic 6-O-alkylguanine residue in DNA in vivo
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inhibits the acetyl-CoA/CO exchange reaction
-
1 mM, about 70% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
14.7
-
pH 7.3, 22°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for iodomethane

ChEBI
PubChem
ChEBI
PubChem