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Ligand alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.3.8

CMP-alpha-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide

0

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.3.8

CMP-alpha-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide

0

-

2.4.3.8

CMP-N-acetylneuraminate + N-alpha-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide

0, 636879, 639653, 637739, 587167, 637736, 637742, 638784, 638788, 639650, 587166

-

2.4.3.8

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (10)

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Show Reference (10 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

587166

3115774

Substrate specificity of GM2 and GD3 synthase of Golgi vesicles derived from rat liver

1987

Klein, D.; Pohlentz, G.; Schwarzmann, G.; Sandhoff, K.

Eur. J. Biochem.

167

417-424

587167

3113445

Oligosialogangliosides inhibit GM2- and GD3-synthesis in isolated Golgi vesicles from rat liver

1987

Yusuf, H.K.M.; Schwarzmann, G.; Pohlentz, G.; Sandhoff, K.

Biol. Chem. Hoppe-Seyler

368

455-462

636879

3838172

Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain

1985

Higashi, H.; Basu, M.; Basu, S.

J. Biol. Chem.

260

824-828

637736

3769920

Ganglioside biosynthesis in rat liver. Characterization of three sialyltransferases

1986

Busam, K.; Decker, K.

Eur. J. Biochem.

160

23-30

637739

4022

Butyrate-induced glycolipid biosynthesis in HeLa cells: properties of the induced sialyltransferase

1976

Fishman, P.H.; Bradley, R.M.; Henneberry, R.C.

Arch. Biochem. Biophys.

172

618-626

637742

2120225

Sub-Golgi distribution in rat liver of CMP-NeuAc GM3- and CMP-NeuAc:GT1b alpha 2->8sialyltransferases and comparison with the distribution of the other glycosyltransferase activities involved in ganglioside biosynthesis

1990

Trinchera, M.; Pirovano, B.; Ghidoni, R.

J. Biol. Chem.

265

18242-18247

638784

2302211

Purification to homogeneity of GD3 synthase and partial purification of GM3 synthase from rat brain

1990

Gu, X.B.; Gu, T.J.; Yu, R.K.

Biochem. Biophys. Res. Commun.

166

387-393

638788

7407217

Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides

1980

Eppler, C.M.; Morré, D.J.; Keenan, T.W.

Biochim. Biophys. Acta

619

332-343

639650

7407216

Ganglioside biosynthesis in rat liver: characterization of cytidine-5-monophospho-n-acetylneuraminic acid:hematoside (GM3) sialyltransferase

1980

Eppler, C.M.; Morré, D.J.; Keenan, T.W.

Biochim. Biophys. Acta

619

318-331

639653

6766128

In vitro biosynthesis of an isomer of brain trisialoganglioside, GT1a

1980

Yohe, H.C.; Yu, R.K.

J. Biol. Chem.

255

608-613

Links to other databases for alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide

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