print visible entries

print all entries

Ligand ADP-L-glycero-beta-D-manno-heptose

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for ADP-L-glycero-beta-D-manno-heptose

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

top print hide

Show Natural Substrate (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

726955, 728139

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + a 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid of the growing core region of lipopolysaccharide = ?

737682

-

2.4.99.24

ADP-L-glycero-beta-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

727413, 728049

-

2.4.99.24

ADP-L-glycero-beta-D-manno-heptose + Kdo2-lipid A = ADP + Hep2-Kdo2-lipid A

736375

-

2.4.99.23

2 entries

2.4.99.24

2 entries

2.4.99.25

ADP-L-glycero-beta-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->7)-alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

761077

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.20

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose

0, 649112

-

Substrate in Enzyme-catalyzed Reactions (16 results)

top print hide

Show Substrate (16 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-amino-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-amino-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-amino-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-amino-1-O-phosphono-alpha-D-glucopyranose

726955

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

726955

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

727413, 728049, 727824

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

726955

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

726955, 728139

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + (3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-(tetradecanoyloxy)tetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->5)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-(tetradecanoyloxy)tetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

726955

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + a 3-deoxy-alpha-D-manno-oct-2-ulopyranosonic acid of the growing core region of lipopolysaccharide = ?

737682

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-[O-deacylated Escherichia coli Kdo2-lipid A] = ADP + alpha-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-[O-deacylated Escherichia coli Kdo2-lipid A]

764290, 764176, 765798

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + lipopolysaccahride from Salmonella minnesota R595 = ADP + ?

727135

-

2.4.99.23

ADP-L-glycero-beta-D-manno-heptose + O-deacylated Kdo2-lipidA = ?

737682

-

2.4.99.24

ADP-L-glycero-beta-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

727413, 728049

-

2.4.99.24

ADP-L-glycero-beta-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->3)-alpha-L-glycero-D-manno-heptosyl-(1->5)-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

727413, 728049

-

2.4.99.24

ADP-L-glycero-beta-D-manno-heptose + Kdo2-lipid A = ADP + Hep2-Kdo2-lipid A

736375

-

2.4.99.25

ADP-L-glycero-beta-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-amino-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-amino-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->7)-alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-amino-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-amino-1-O-phosphono-alpha-D-glucopyranose

761077

-

2.4.99.25

ADP-L-glycero-beta-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(hydroxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->7)-alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-[[(3R)-3-(hydroxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

761077

-

2.4.99.25

ADP-L-glycero-beta-D-manno-heptose + alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose = ADP + alpha-L-glycero-D-manno-heptosyl-(1->7)-alpha-L-glycero-D-manno-heptosyl-(1->3)-((4-O-phospho)-alpha-L-glycero-D-manno-heptosyl-(1->5))-[(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)]-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-2-[[(3R)-3-(dodecanoyloxy)tetradecanoyl]amino]-4-O-phospho-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose

761077

-

2.4.99.23

10 entries

2.4.99.24

3 entries

2.4.99.25

3 entries

Product in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.20

ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose

2360, 2359, 2355, 2356, 2357, 2358, 0, 649112

-

5.1.3.20

ADP-D-glycero-D-mannoheptose = ADP-L-glycero-D-mannoheptose

0

-

5.1.3.20

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (6 results)

top print hide

Show Turnover Number (6 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.99.23

0.198

-

pH 7.5, 37°C, mutant enzyme R60A

765798

2.4.99.23

0.32

-

pH 7.5, 37°C, mutant enzyme R120A

765798

2.4.99.23

0.33

-

pH 7.5, 37°C, mutant enzyme R64A

765798

2.4.99.23

0.36

-

pH 7.5, 37°C, mutant enzyme R61A

765798

2.4.99.23

0.36

-

pH 7.5, 37°C, wild-type enzyme

765798

2.4.99.23

0.41

-

pH 7.5, 37°C, mutant enzyme R63A

765798

2.4.99.23

6 entries

K_M Value (6 results)

top print hide

Show KM Value (6 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.99.23

0.0025

-

pH 7.5, 37°C, mutant enzyme R61A

765798

2.4.99.23

0.0029

-

pH 7.5, 37°C, wild-type enzyme

765798

2.4.99.23

0.006

-

pH 7.5, 37°C, mutant enzyme R60A

765798

2.4.99.23

0.008

-

pH 7.5, 37°C, mutant enzyme R64A

765798

2.4.99.23

0.01

-

pH 7.5, 37°C, mutant enzyme R63A

765798

2.4.99.23

0.015

-

pH 7.5, 37°C, mutant enzyme R120A

765798

2.4.99.23

6 entries

References & Links

Literature References (19)

top print hide

Show Reference (19 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

2355

2198271

Cloning, expression, and characterization of the Escherichia coli K-12 rfaD gene

1990

Pegues, J.C.; Chen, L.; Gordon, A.W.; Ding, L.; Coleman, W.G.

J. Bacteriol.

172

4652-4660

2356

6337148

The rfaD gene codes for ADP-L-glycero-D-mannoheptose-6-epimerase

1983

Coleman, W.G.

J. Biol. Chem.

258

1985-1990

2357

7929099

Purification and properties of the Escherichia coli K-12 NAD-dependent nucleotide diphosphosulfate epimerase, ADP-L-glycero-D-mannoheptose 6-epimerase

1994

Ding, L.; Seto, B.L.; Ahmed, S.A.; Coleman, W.G.

J. Biol. Chem.

269

24384-24390

2358

7730260

A mutation in the Neisseria gonorrhoeae rfaD homolog results in altered lipooligosaccharide expression

1995

Drazek, E.S.; Stein, D.C.; Deal, C.D.

J. Bacteriol.

177

2321-2327

2359

9119477

Identification of the ADP-L-glycero-D-manno-heptose-6-epimerase (rfaD) and heptosyltransferase II (rfaF) biosynthesis genes from nontypeable Haemophilus influenzae 2019

1997

Nichols, W.A.; Gibson, B.W.; Melaugh, W.; Lee, N.G.; Sunshine, M.; Apicella, M.A.

Infect. Immun.

65

1377-1386

2360

8157607

Molecular analysis of the rfaD gene, for heptose synthesis, and the rfaF gene, for heptose transfer, in lipopolysaccharide synthesis in Salmonella typhimurium

1994

Sirisena, D.M.; MacLachlan, P.R.; Liu, S.L.; Hessel, A.; Sanderson, K.E.

J. Bacteriol.

176

2379-2385

649112

10089470

Crystallization and preliminary X-ray diffraction studies of the lipopolysaccharide core biosynthetic enzyme ADP-L-glycero-D-mannoheptose 6-epimerase from Escherichia coli K-12

1999

Ding, L.; Zhang, Y.; Deacon, A.M.; Ealick, S.E.; Ni, Y.; Sun, P.; Coleman, W.G., Jr.

Acta Crystallogr. Sect. D

55

685-688

726955

22059588

Lipopolysaccharide biosynthesis without the lipids: recognition promiscuity of Escherichia coli heptosyltransferase I

2011

Czyzyk, D.J.; Liu, C.; Taylor, E.A.

Biochemistry

50

10570-10572

727135

18571407

Discovery of new Gram-negative antivirulence drugs: structure and properties of novel E. coli WaaC inhibitors

2008

Moreau, F.; Desroy, N.; Genevard, J.M.; Vongsouthi, V.; Gerusz, V.; Le Fralliec, G.; Oliveira, C.; Floquet, S.; Denis, A.; Escaich, S.; Wolf, K.; Busemann, M.; Aschenbrenner, A.

Bioorg. Med. Chem. Lett.

18

4022-4026

727413

11054112

Comparative functional characterization in vitro of heptosyltransferase I (WaaC) and II (WaaF) from Escherichia coli

2000

Gronow, S.; Brabetz, W.; Brade, H.

Eur. J. Biochem.

267

6602-6611

727824

9446588

Enzymatic synthesis of lipopolysaccharide in Escherichia coli. Purification and properties of heptosyltransferase I

1998

Kadrmas, J.L.; Raetz, C.R.

J. Biol. Chem.

273

2799-2807

728049

11717579

Characterization of the physiological substrate for lipopolysaccharide heptosyltransferases I and II

2001

Gronow, S.; Oertelt, C.; Ervelä, E.; Zamyatina, A.; Kosma, P.; Skurnik, M.; Holst, O.

J. Endotoxin Res.

7

263-270

728139

16963083

Structure of the Escherichia coli heptosyltransferase WaaC: binary complexes with ADP and ADP-2-deoxy-2-fluoro heptose

2006

Grizot, S.; Salem, M.; Vongsouthi, V.; Durand, L.; Moreau, F.; Dohi, H.; Vincent, S.; Escaich, S.; Ducruix, A.

J. Mol. Biol.

363

383-394

736375

27214006

Deletion of the genes waaC, waaF, or waaG in Escherichia coli W3110 disables the flagella biosynthesis

2016

Wang, Z.; Wang, J.; Ren, G.; Li, Y.; Wang, X.

J. Basic Microbiol.

56

1021-1035

737682

23865375

Escherichia coli heptosyltransferase I: investigation of protein dynamics of a GT-B structural enzyme

2013

Czyzyk, D.J.; Sawant, S.S.; Ramirez-Mondragon, C.A.; Hingorani, M.M.; Taylor, E.A.

Biochemistry

52

5158-5160

761077

25957775

Cloning and characterization of the Escherichia coli heptosyltransferase III Exploring substrate specificity in lipopolysaccharide core biosynthesis

2015

Mudapaka, J.; Taylor, E.A.

FEBS Lett.

589

1423-1429

764176

32011131

Opposites Attract Escherichia coli heptosyltransferase i conformational changes induced by interactions between the substrate and positively charged residues

2020

Cote, J.; Hecht, C.; Patel, K.; Ramirez-Mondragon, C.; Sham, Y.; Taylor, E.

Biochemistry

59

3135-3147

764290

29398539

Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A

2018

Nkosana, N.; Czyzyk, D.; Siegel, Z.; Cote, J.; Taylor, E.

Bioorg. Med. Chem. Lett.

28

594-600

765798

35508636

Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action

2022

Milicaj, J.; Hassan, B.; Cote, J.; Ramirez-Mondragon, C.; Jaunbocus, N.; Rafalowski, A.; Patel, K.; Castro, C.; Muthyala, R.; Sham, Y.; Taylor, E.

Sci. Rep.

12

7302

Links to other databases for ADP-L-glycero-beta-D-manno-heptose

top print hide

Show Links (1 entry)

ChEBI

PubChem