Ligand DL-methionine

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Basic Ligand Information

Molecular Structure
Picture of DL-methionine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11NO2S
DL-methionine
FFEARJCKVFRZRR-UHFFFAOYSA-N
Synonyms:
2-amino-4-(methylthio)butanoic acid, 2-amino-4-methylthiobutanoate, D,L-methionine, D,L-methionine-(methyl-D3)

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-methionine + O2 = ? + H2O2
show the reaction diagram
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DL-methionine + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-methionine + O2 = ? + H2O2
show the reaction diagram
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DL-methionine + H2O + O2 = 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
show the reaction diagram
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ATP + D,L-methionine-(methyl-D3) + H2O = ?
show the reaction diagram
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phenylpyruvate + DL-methionine = phenylalanine + 4-methylsulfanyl-2-oxobutanoate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
DL-methionine (S)-sulfoxide + thioredoxin = DL-methionine + thioredoxin disulfide + H2O
show the reaction diagram
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DL-methionine (R)-sulfoxide + thioredoxin = DL-methionine + thioredoxin disulfide + H2O
show the reaction diagram
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L-phenylalanine + 4-methylthio-2-oxobutanoate = phenylpyruvate + 2-amino-4-methylthiobutanoate
show the reaction diagram
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DL-methioninamide + H2O = DL-methionine + NH3
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1mM, relative activity 140%
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
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strong inhibition at 10 and 50 mM, in the presence of 0.1 mM MnCl2
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activates at concentrations of 1-30 mM, inhibitory at over 50 mM, overview
-
competitive inhibition, 40 mM
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Enzyme Kinetic Parameters

KM Value (1 result)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
4
-
pH 7.5

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
26.9
-
pH 8.0, 37°C

References & Links

Links to other databases for DL-methionine

ChEBI
PubChem
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PubChem