Ligand Pyridine-3-aldehyde

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Basic Ligand Information

Molecular Structure
Picture of Pyridine-3-aldehyde (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H5NO
Pyridine-3-aldehyde
QJZUKDFHGGYHMC-UHFFFAOYSA-N
Synonyms:
3-Formylpyridine, 3-pyridine-carboxyaldehyde, 3-pyridine carboxaldehyde, 3-Pyridinecarboxaldehyde, 3-pyridinecarboxyaldehyde, 3-pyridine carboxyaldehyde, 3-Pyridylcarboxaldehyde, nicotinaldehyde, nicotinic aldehyde, pyridin-3-carboxyaldehyde, pyridine-3-carbaldehyde, Pyridine-3-carboxaldehyde, pyridine-3-carboxyaldehyde, pyridine 3-aldehyde

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (35 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyridine 3-aldehyde + NADPH + H+ = (pyridin-3-yl)methanol + NADP+
show the reaction diagram
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pyridine-3-aldehyde + NADPH = 3-hydroxypyridine + NADP+
show the reaction diagram
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3-pyridinecarboxaldehyde + NADPH = 3-pyridinemethanol + NADP+
show the reaction diagram
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pyridine-3-aldehyde + NADH + H+ = ? + NAD+
show the reaction diagram
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pyridine-3-aldehyde + NADPH = pyridine-3-ol + NADP+
show the reaction diagram
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3-pyridine carboxaldehyde + NAD(P)H = 3-pyridinemethanol + NAD(P)+
show the reaction diagram
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pyridine-3-aldehyde + NADP+ = pyridin-3-ylmethanol + NADPH + H+
show the reaction diagram
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pyridine-3-carboxaldehyde + NADPH = pyridine-3-methanol + NADP+
show the reaction diagram
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pyridine-3-carboxyaldehyde + 5-methylphenazinium methyl sulfate + H2O = ?
show the reaction diagram
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3-pyridine carboxaldehyde + NAD+ + H2O = 3-pyridine carboxylic acid + NADH + 2 H+
show the reaction diagram
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pyridin-3-carboxyaldehyde + NAD+ + H2O = pyridin-3-formiate + NADH
show the reaction diagram
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3-pyridinecarboxaldehyde + H2O + 2,6-dichlorophenol-indophenol = 3-pyridinecarboxylate + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
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pyridine-3-aldehyde + NADPH = ?
show the reaction diagram
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pyruvate + 3-pyridine carboxaldehyde = ?
show the reaction diagram
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D-ribulose 5-phosphate + pyridine-3-carboxaldehyde = ?
show the reaction diagram
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3-pyridinecarboxaldehyde + pyruvate = (3E)-2-oxo-4-pyridin-3-ylbut-3-enoate + H2O
show the reaction diagram
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cyanide + pyridine-3-carbaldehyde = (2R)-hydroxy(pyridin-3-yl)ethanenitrile
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-pyridylcarbinol + NAD+ = pyridine-3-carbaldehyde + NADH
show the reaction diagram
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3-pyridinemethanol + NADP+ = 3-pyridinecarboxaldehyde + NADPH
show the reaction diagram
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3-chloropyridine + H2O2 = 3-chloropyridine N-oxide + nicotinic alcohol + nicotinic aldehyde + nicotinic acid + H2O
show the reaction diagram
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3-aminomethylpyridine + H2O + O2 = pyridine-3-carbaldehyde + NH3 + H2O2
show the reaction diagram
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3-aminomethylpyridine + H2O + O2 = 3-formylpyridine + NH3 + H2O2
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition at elevated aldehyde concentration, increase of NAD+ concentration from 0.85 mM to 2.55 mM removes substrate inhibition
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10.6% inhibition at 30 mM
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weak inhibition of phosphorylase I, not II
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.132
-
at pH 7.4 and 37°C
26.8
-
-
2.2
-
pH 9.0, 37°C
68
-
-
27.7
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enzyme ALDH-2

KM Value (40 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.6
-
-
0.046
-
-
0.316
-
pH 9.0, 37°C
0.026
-
-
0.00196
-
enzyme ALDH-2

Ki Value (12 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.000015
-
pH 7.3, 37°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.054
-
pH and temperature not specified in the publication

References & Links

Links to other databases for Pyridine-3-aldehyde

ChEBI
PubChem
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PubChem