Ligand (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
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Basic Ligand Information
Molecular Structure

C20H32O4
(5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
QQUFCXFFOZDXLA-GTYUHVKWSA-N
(5Z,8R,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate, (8R)-HPETE, (8R)-hydroperoxyeicosatetraenoic acid, 8(R)-HPETE
Show all BRENDA pathways known for (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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(8R)-hydroperoxyeicosatetraenoic acid = ?
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
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Substrate in Enzyme-catalyzed Reactions (4 results)
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(8R)-hydroperoxyeicosatetraenoic acid = ?
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Product in Enzyme-catalyzed Reactions (1 result)
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arachidonate + O2 = (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate
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Enzyme Kinetic Parameters
References & Links
Literature References (3)
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The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase
2003
Yu, Z.; Schneider, C.; Boeglin, W.E.; Marnett, L.J.; Brash, A.R.
Proc. Natl. Acad. Sci. USA
100
9162-9167
Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin
2006
Yu, Z.; Schneider, C.; Boeglin, W.E.; Brash, A.R.
Arch. Biochem. Biophys.
455
188-196
Cytochrome P450-type hydroxylation and epoxidation in a tyrosine-liganded hemoprotein, catalase-related allene oxide synthase
2012
Boeglin, W.E.; Brash, A.R.
J. Biol. Chem.
287
24139-24147
Links to other databases for (5Z,9E,11Z,14Z)-(8R)-8-hydroperoxyicosa-5,9,11,14-tetraenoate