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Ligand (3R)-3-hydroxydecanoyl-[acyl-carrier protein]

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

lipid metabolism, palmitate biosynthesis

KEGG

Fatty acid biosynthesis, Fatty acid metabolism

MetaCyc

(5Z)-dodecenoate biosynthesis I, lipid IVA biosynthesis (P. putida), palmitate biosynthesis II (type II fatty acid synthase), palmitate biosynthesis III, polyhydroxydecanoate biosynthesis, streptorubin B biosynthesis, tetradecanoate biosynthesis (mitochondria) more

Show all BRENDA pathways known for (3R)-3-hydroxydecanoyl-[acyl-carrier protein]

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

4.2.1.59

(3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2-decenoyl-[acyl-carrier protein] + H2O

730467

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.129

(R)-3-hydroxydecanoyl-[acyl-carrier protein] + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose = [acyl-carrier protein] + UDP-3-N-(3-hydroxydecanoyl)-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose

659349

-

2.3.1.129

R-3-hydroxydecanoyl-[acyl carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-hydroxydecanoyl-N-acetylglucosamine

689754

-

2.3.1.129

2 entries

4.2.1.59

(3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2-decenoyl-[acyl-carrier protein] + H2O

5799, 730467

-

Enzyme Kinetic Parameters

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

5799

4881058

Intermediate- and long-chain beta-hydroxyacyl-ACP dehydratases from E. coli fatty acid synthetase

1968

Mizugaki, M.; Swindell, A.C.; Wakil, S.J.

Biochem. Biophys. Res. Commun.

33

520-527

659349

15044493

Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group

2004

Sweet, C.R.; Williams, A.H.; Karbarz, M.J.; Werts, C.; Kalb, S.R.; Cotter, R.J.; Raetz, C.R.

J. Biol. Chem.

279

25411-25419

689754

17698807

Structural basis for the acyl chain selectivity and mechanism of UDP-N-acetylglucosamine acyltransferase

2007

Williams, A.H.; Raetz, C.R.

Proc. Natl. Acad. Sci. USA

104

13543-13550

730467

24362570

Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

2014

Nguyen, C.; Haushalter, R.; Lee, D.; Markwick, P.; Bruegger, J.; Caldara-Festin, G.; Finzel, K.; Jackson, D.; Ishikawa, F.; O'Dowd, B.; McCammon, J.; Opella, S.; Tsai, S.; Burkart, M.

Nature

505

427-431

Links to other databases for (3R)-3-hydroxydecanoyl-[acyl-carrier protein]

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