Ligand 8,11,14-eicosatrienoic acid

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of 8,11,14-eicosatrienoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H34O2
8,11,14-eicosatrienoic acid
HOBAELRKJCKHQD-QNEBEIHSSA-N
Synonyms:
(8Z,11Z,14Z)-eicosatrienoate, (8Z,11Z,14Z)-eisosatrienoic acid, (8Z,11Z,14Z)-Icosatrienoate, (8Z,11Z,14Z)-Icosatrienoic acid, 8,11,14-Eicosatrienoate, 20:3(n-6) fatty acid, bishomo-gamma-linolenic acid, cis-8,11,14-eicosatrienoic acid, di-homo-gamma-linolenate, di-homo-gamma-linolenic acid, dihomo-gamma-linolenate, dihomo-gamma-linolenic acid, dihomo-gamma-linolenoyl-CoA, dihomo-gamma linolenic acid, eicosa-8,11,14-trienoic acid


Show all pahtways known for Show all BRENDA pathways known for 8,11,14-eicosatrienoic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+ = arachidonic acid + ferricytochrome b5 + H2O
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(8Z,11Z,14Z)-eicosatrienoate = ?
show the reaction diagram
-
ATP + 8,11,14-eicosatrienoate + CoA = AMP + diphosphate + 8,11,14-eicosatrienoyl-CoA
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
11,14-eicosadienoic acid + reduced acceptor + O2 = 8,11,14-eicosatrienoic acid + acceptor + H2O
show the reaction diagram
-
-
8,11,14-eicosatrienamide + H2O = 8,11,14-eicosatrienoic acid + NH3
show the reaction diagram
-
-
ATP + dihomo-gamma-linolenate + CoA = AMP + diphosphate + dihomo-gamma-linolenoyl-CoA
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
68% inhibition at 0.02 mM
-
competitive inhibitor of palmitoleic acid activation
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (12 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0245
-
at pH 7.4 and 37°C
0.06
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.00219
-
IC50: 0.00219 mM

References & Links

Links to other databases for 8,11,14-eicosatrienoic acid

ChEBI
PubChem
-
PubChem