Ligand Prednisone

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Basic Ligand Information

Molecular Structure
Picture of Prednisone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H26O5
Prednisone
XOFYZVNMUHMLCC-ZPOLXVRWSA-N
Synonyms:
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione, 1,4-Pregnene-17alpha,21-diol-3,11,20-trione, 17alpha,21-Dihydroxy-1,4-pregnadien-3,11,20-trione, 17alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
17alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione + NADPH = 11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione + NADP+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
17alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione + NADPH = 11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione + NADP+
show the reaction diagram
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1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione + NADPH + O2 = ?
show the reaction diagram
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prednisone + reduced adrenodoxin + O2 = ? + oxidized adrenodoxin + H2O
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ATP + H2O + prednisone/in = ADP + phosphate + prednisone/out
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Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
cortisone + acceptor = 1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
show the reaction diagram
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ATP + H2O + prednisone/in = ADP + phosphate + prednisone/out
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
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Enzyme Kinetic Parameters

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0175
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androsterone oxidation

References & Links

Links to other databases for Prednisone

ChEBI
PubChem
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PubChem