Ligand 2,4,6-Trichlorophenol

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Basic Ligand Information

Molecular Structure
Picture of 2,4,6-Trichlorophenol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H3ClO
2,4,6-Trichlorophenol
LINPIYWFGCPVIE-UHFFFAOYSA-N
Synonyms:
2',4',6'-trichlorophenol, 2,4,6-trichlorphenol, trichlorophenol, trichloro phenol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
2,4,6-trichlorophenol + FADH2 + O2 = 2,6-dichloro-1,4-benzoquinone + Cl- + FAD + H2O
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Substrate in Enzyme-catalyzed Reactions (20 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
2,4,6-trichlorophenol + O2 = ?
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show the reaction diagram
2,4,6-trichlorophenol + H2O2 = ?
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show the reaction diagram
2,4,6-trichlorophenol + H2O2 = ? + H2O
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show the reaction diagram
2,4,6-trichlorophenol + H2O2 + H+ = ?
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show the reaction diagram
2,4,6-trichlorophenol + NADH + H+ + O2 = 2,6-dichlorohydroquinone + 6-chloro-2-hydroxyquinol + ? + NAD+ + H2O
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show the reaction diagram
2,4,6-trichlorophenol + NADPH + O2 = ?
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show the reaction diagram
2,4,6-trichlorphenol + O2 = 2,6-dichlorohydroquinone + H2O + Cl-
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show the reaction diagram
2,4,6-trichlorophenol + reduced acceptor = 4-chlorophenol + chloride + oxidized acceptor
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show the reaction diagram
UDP-glucose + 2,4,6-trichlorophenol = UDP + 2,4,6-trichlorophenylglucoside
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
1,3,5-trichlorobenzene + putidaredoxin + O2 = 2,4,6-trichlorophenol + oxidized putidaredoxin + H2O
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Activator in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
induction of MAR activity in wild type strain
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition at high concentration due to the internal binding at the distal pocket of DHP; substrate inhibition at high concentration due to the internal binding at the distal pocket of DHP
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at 2,4,6-trichlorophenol concentrations higher than 0.1 mM, substrate inhibition which amounts to 43% at 0.2 mM 2,4,6-trichlorophenol and to 72% at 0.33 mM 2,4,6-trichlorophenol is observed
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
in 0.1 M acetate buffer pH 5.0, at 25°C
11.28
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pH 7.0, temperature not specified in the publication

KM Value (4 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
pH 7.0, temperature not specified in the publication
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0.1359
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IC50 Value (1 result)

COMMENTARY
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
LITERATURE
in 0.1 M sodium phosphate, pH 7.2, and 2 mM EDTA for 30 min at 16°C
0.00037
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References & Links

Links to other databases for 2,4,6-Trichlorophenol

ChEBI
PubChem
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PubChem