Ligand orsellinic acid
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Basic Ligand Information
C8H8O4
orsellinic acid
AMKYESDOVDKZKV-UHFFFAOYSA-N
2,4-dihydroxy-6-methylbenzoate, 2,4-dihydroxy-6-methylbenzoic acid, orsellinate
Related pathways
MetaCyc
daurichromenate biosynthesis
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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Orsellinic acid = 1,3-Dihydroxy-5-methylbenzene + CO2
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2,4-Dihydroxy-6-methylbenzoate = 1,3-Dihydroxy-5-methylbenzene + CO2
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Product in Enzyme-catalyzed Reactions (3 results)
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evernic acid + H2O = orsellinic acid + everninic acid
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gyrophoric acid + H2O = orsellinic acid
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lecanoric acid + H2O = orsellinic acid
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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45% inhibition of PTPB1 at 0.178 mM
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Enzyme Kinetic Parameters
KM Value (3 results)
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References & Links
Literature References (8)
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6-Methylsalicylic acid (2,6-cresotic acid) decarboxylase
1975
Light, R.J.; Vogel, G.
Methods Enzymol.
43
530-540
Studies on lichen enzymes: Purification and properties of orsellinate decarboxylase obtained from Lasallia pustulata
1971
Mosbach, K.; Schultz, J.
Eur. J. Biochem.
22
485-488
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An orsellinic acid decarboxylase isolated from Gliocladium roseum
1965
Petterson, G.
Acta Chem. Scand.
19
2013-2021
Studies on lichen enzymes. Purification and properties of an orsellinate depside hydrolase obtained from Lasallia pustulata
1971
Schultz, J.; Mosbach, K.
Eur. J. Biochem.
22
153-157
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Kinetics and stability of an immobilized orsellinate depside hydrolase in polyacrylamide gel
1991
Garcia-Junceda, E.; Cambon, C.; Vicente, C.
Enzyme Microb. Technol.
13
275-279
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060
2009
Seo, C.; Sohn, J.H.; Oh, H.; Kim, B.Y.; Ahn, J.S.
Bioorg. Med. Chem. Lett.
19
6095-6097
Comparative modeling and virtual screening for the identification of novel inhibitors for myo-inositol-1-phosphate synthase
2014
Azam, S.S.; Sarfaraz, S.; Abro, A.
Mol. Biol. Rep.
41
5039-5052
Comparative modeling and virtual screening for the identification of novel inhibitors for myo-inositol-1-phosphate synthase
2014
Azam, S.S.; Sarfaraz, S.; Abro, A.
Mol. Biol. Rep.
41
5039-5052
Links to other databases for orsellinic acid
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