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BRENDA support

Ligand butane-1,4-diol

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Basic Ligand Information

Molecular Structure
Picture of butane-1,4-diol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H10O2
butane-1,4-diol
WERYXYBDKMZEQL-UHFFFAOYSA-N
Synonyms:
1,4-butandiol, 1,4-Butanediol, butan-1,4-diol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,4-butanediol + NAD+ = 4-hydroxybutanal + NADH + H+
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (25 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1,4-butanediol + NAD+ = ? + NADH + H+
show the reaction diagram
1,4-butanediol + NAD+ = 1-hydroxy-4-butanal + NADH
show the reaction diagram
-
butane-1,4-diol + NADP+ = ? + NADPH
show the reaction diagram
-
1,4-butanediol + ferricytochrome c = ?
show the reaction diagram
-
butane-1,4-diol + O2 = oxolan-2-one + H2O2
show the reaction diagram
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1,4-butanediol + O2 = 1,4-butanedione + H2O2
show the reaction diagram
-
1,4-butanediol + O2 = ?
show the reaction diagram
-
1,4-butanediol + O2 = ?
show the reaction diagram
-
1,4-butanediol + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
1,4-butanediol + ferricyanide = 4-hydroxybutanal + ferrocyanide
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
polyesters poly(butylene succinate) + H2O = succinic acid + 1,4-butanediol + ?
show the reaction diagram
-
poly(butylene succinate) + H2O = succinic acid + 1,4-butanediol + ?
show the reaction diagram
-
4-chlorobutanol + H2O = butane-1,4-diol + chloride
show the reaction diagram
-

Activator in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-
affect the activity only to a slight extent, rFIXa
-
isoform AC6 shows about 30% stimulation of activity with 100 mM 1,4-butanediol, isoform AC7 shows about 25% stimulation of activity with 100 mM 1,4-butanediol, isoform AC9 shows about 40% stimulation of activity with 100 mM 1,4-butanediol
-

3D Structure of Enzyme-Ligand-Complex (PDB) (132 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (3 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
1.98
-
pH 10, 60°C
0.502
-
pH 9.5, 30°C, mutant V84I/Y127M
6.74
-
pH 7.5, temperature not specified in the publication

KM Value (4 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.36
-
pH 10, 60°C
15.1
-
pH 9.5, 30°C, recombinant mutant V84I/Y127M
71
-
pH and temperature not specified in the publication
198
-
pH 7.5, temperature not specified in the publication

References & Links

Links to other databases for butane-1,4-diol

ChEBI
PubChem
ChEBI
PubChem