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Ligand IDP

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for IDP

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.205

inosine 5'-diphosphate + NAD+ + H2O = xanthosine 5'-diphosphate + NADH + H+

726095, 726097

-

3.6.1.15

IDP + H2O = IMP + phosphate

696153, 696275

-

3.6.1.9

IDP + H2O = IMP + phosphate

246808

-

In Vivo Product in Enzyme-catalyzed Reactions (5 results)

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Show Natural Product (5 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.4.7

adenosine diphosphate + H2O = inosine diphosphate + NH3

0

-

3.6.1.15

ITP + H2O = IDP + phosphate

0

-

3.6.1.73

inosine 5'-triphosphate + H2O = inosine 5'-diphosphate + phosphate

0

-

3.6.5.3

ITP + H2O = IDP + phosphate

644150, 644152

-

4.1.1.32

ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2

0

-

Substrate in Enzyme-catalyzed Reactions (28 results)

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Show Substrate (28 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.205

inosine 5'-diphosphate + NAD+ + H2O = xanthosine 5'-diphosphate + NADH

347958, 347963

-

1.1.1.205

inosine 5'-diphosphate + NAD+ + H2O = xanthosine 5'-diphosphate + NADH + H+

724347, 724327, 726095, 726097

-

1.1.1.205

2 entries

1.17.4.2

IDP + reduced thioredoxin = dIDP + oxidized thioredoxin

437889

-

2.7.1.146

D-fructose 6-phosphate + IDP = D-fructose 1,6-bisphosphate + IMP

698924

-

2.7.1.40

IDP + phosphoenolpyruvate = ITP + pyruvate

641555, 641551, 641523, 641539, 708992, 641546, 641516, 641562, 641584, 641545, 641567, 641576, 641532, 641589

-

2.7.3.8

IDP + phosphoramide = ITP + NH3

642495

-

2.7.4.6

dATP + IDP = dADP + ITP

642652

6xpu, 3D-view

2.7.6.4

ATP + IDP = AMP + inosine 3'-diphosphate 5'-diphosphate

645211, 645217

-

2.7.6.4

dATP + IDP = dAMP + inosine 3'-diphosphate 5'-triphosphate

645211

-

2.7.6.4

2 entries

2.7.7.5

IDP + phosphate = phosphate + IDP

643453

-

2.7.7.8

poly(I) + IDP = poly(I)+1 + phosphate

643680, 643679, 643691, 643683, 643686

-

3.1.3.2

IDP + H2O = ?

651405

-

3.1.3.2

IDP + H2O = IMP + phosphate

694602, 134710

-

3.1.3.2

2 entries

3.1.3.60

IDP + H2O = ?

646423

-

3.6.1.1

IDP + H2O = ?

734503

-

3.6.1.15

IDP + H2O = IMP + phosphate

696153, 696275

-

3.6.1.42

IDP + H2O = IMP + phosphate

210055, 758117

-

3.6.1.5

IDP + H2O = ?

733585

-

3.6.1.5

IDP + H2O = IMP + phosphate

210151, 210166, 654862, 210144, 210148, 210149, 210132, 210141, 209778, 210133, 720261, 735003, 210167, 669222

-

3.6.1.5

2 entries

3.6.1.6

IDP + H2O = IMP + phosphate

210202, 210204, 210205, 210206, 210208, 210209, 210211, 210213, 210216, 210217, 656961, 757160, 654678, 656079

-

3.6.1.62

IDP + H2O = IMP + phosphate

758123

-

3.6.1.64

IDP + H2O = IMP + phosphate

720583

-

3.6.1.9

IDP + H2O = ?

730589

-

3.6.1.9

IDP + H2O = IMP + phosphate

246808, 713555

-

3.6.1.9

2 entries

4.1.1.32

IDP + phosphoenolpyruvate + CO2 = ITP + oxaloacetate

4350, 4347, 4351, 4352, 4368, 4348, 4357, 4369, 728430

-

5.6.1.7

IDP + H2O + a folded polypeptide = IMP + phosphate + an unfolded polypeptide

711214

-

6.2.1.13

IDP + phosphate + acetyl-CoA = ITP + acetate + CoA

627, 625, 744820

-

7.2.2.1

IDP + phosphate + Na+/out = ITP + H2O + Na+/in

654801

-

Product in Enzyme-catalyzed Reactions (124 results)

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Show Product (124 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.13

IDP-glucose + D-fructose = IDP + sucrose

0

-

2.7.1.1

ITP + D-glucose = IDP + D-glucose 6-phosphate

0

-

2.7.1.105

ITP + beta-D-fructose 6-phosphate = IDP + beta-D-fructose 2,6-bisphosphate

0

-

2.7.1.107

ITP + sn-1,2-dihexanoylglycerol = IDP + sn-1,2-dihexanoylglycerol 3-phosphate

0

-

2.7.1.11

ITP + D-fructose 6-phosphate = IDP + D-fructose 1,6-bisphosphate

640421, 640446, 640485, 640443, 640426, 640518, 0, 640463, 640436, 640513, 640495, 640515, 640509

-

2.7.1.12

ITP + D-gluconate = IDP + 6-phospho-D-gluconate

0

-

2.7.1.144

ITP + D-tagatose 6-phosphate = IDP + D-tagatose 1,6-bisphosphate

0

-

2.7.1.15

ITP + D-ribose = IDP + D-ribose 5-phosphate

0

-

2.7.1.157

ITP + N-acetyl-alpha-D-galactosamine = IDP + N-acetyl-alpha-D-galactosamine 1-phosphate

0

-

2.7.1.162

ITP + N-acetyl-alpha-D-glucosamine = IDP + N-acetyl-alpha-D-glucosamine 1-phosphate

0

-

2.7.1.164

ITP + L-seryl-tRNASec = IDP + O-phospho-L-seryl-tRNASec

0

-

2.7.1.17

ITP + 1-deoxy-D-xylulose = IDP + 1-deoxy-D-xylulose 5-phosphate

645057

-

2.7.1.17

ITP + D-xylulose = IDP + D-xylulose 5-phosphate

0

-

2.7.1.17

2 entries

2.7.1.190

ITP + dibekacin = IDP + dibekacin 2''-phosphate

0

-

2.7.1.2

ITP + D-glucose = IDP + D-glucose 6-phosphate

0

-

2.7.1.20

ITP + adenosine = IDP + AMP

641082, 641086, 641075, 641093, 641095, 0, 641096

-

2.7.1.229

ITP + 2-deoxy-D-ribose = IDP + 2-deoxy-D-ribose 5-phosphate

0

-

2.7.1.23

ITP + NAD+ = IDP + NADP+

0, 641177

-

2.7.1.28

ITP + D-glyceraldehyde = IDP + D-glyceraldehyde-3-phosphate

641261

-

2.7.1.29

ITP + dihydroxyacetone = IDP + dihydroxyacetone phosphate

641267, 641268

-

2.7.1.30

ITP + glycerol = IDP + glycerol 3-phosphate

0

-

2.7.1.33

ITP + pantothenate = IDP + D-4'-phosphopantothenate

0

-

2.7.1.36

ITP + (R)-mevalonate = IDP + (R)-5-phosphomevalonate

0

-

2.7.1.36

ITP + mevalonate = IDP + phosphomevalonate

641438, 641434, 641440, 641443, 641436, 641431

-

2.7.1.36

2 entries

2.7.1.4

ITP + D-fructose = IDP + D-fructose 6-phosphate

0

-

2.7.1.43

ITP + D-glucuronate = IDP + 1-phospho-D-glucuronate

0

-

2.7.1.45

ITP + 2-dehydro-3-deoxy-D-gluconate = IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

0

-

2.7.1.48

ITP + uridine = IDP + UMP

641638, 641643

-

2.7.1.52

ITP + 6-deoxy-L-galactose = IDP + 6-deoxy-L-galactose 1-phosphate

0

-

2.7.1.54

ITP + D-arabinose = IDP + D-arabinose 5-phosphate

0

-

2.7.1.56

ITP + D-fructose 1-phosphate = IDP + D-fructose 1,6-bisphosphate

641685, 0, 641679, 640495, 640483

-

2.7.1.59

ITP + N-acetyl-D-glucosamine = IDP + N-acetyl-D-glucosamine 6-phosphate

0

-

2.7.1.6

ITP + D-galactose = IDP + alpha-D-galactose 1-phosphate

0

-

2.7.1.63

ITP + D-glucose = IDP + D-glucose 6-phosphate

0

-

2.7.1.67

ITP + 1-phosphatidyl-1D-myo-inositol = IDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

0

-

2.7.1.7

ITP + 2-deoxy-D-mannose = IDP + 2-deoxy-D-mannose 6-phosphate

0

-

2.7.1.7

ITP + D-glucose = IDP + D-glucose 6-phosphate

0

-

2.7.1.7

ITP + D-mannosamine = IDP + D-mannosamine 6-phosphate

0

-

2.7.1.7

ITP + D-mannose = IDP + D-mannose 6-phosphate

0

-

2.7.1.7

ITP + mannoheptulose = IDP + mannoheptulose 6-phosphate

0

-

2.7.1.7

5 entries

2.7.1.82

ITP + ethanolamine = IDP + O-phosphoethanolamine

0

-

2.7.1.85

ITP + cellobiose = IDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose

642059

-

2.7.1.86

ITP + NADH = IDP + NADPH

0

-

2.7.1.B20

ITP + cytidine = IDP + CMP

0

-

2.7.1.B20

ITP + guanosine = IDP + GMP

0

-

2.7.1.B20

ITP + guanosine = IDP + guanosine 5'-phosphate

0

-

2.7.1.B20

ITP + inosine = IDP + IMP

0

-

2.7.1.B20

ITP + inosine = IDP + inosine 5'-phosphate

0

-

2.7.1.B20

5 entries

2.7.11.31

ITP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = IDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate

0

-

2.7.2.1

ITP + acetate = IDP + acetyl phosphate

642182, 642166, 0, 642173, 642178, 642176, 642189, 642184, 487537, 642179

-

2.7.2.10

ITP + 3-phospho-D-glycerate = IDP + 3-phospho-D-glyceroyl 1-phosphate

0

-

2.7.2.14

ITP + isobutanoate = IDP + isobutanoyl phosphate

0

-

2.7.2.18

ITP + isobutyrate = IDP + isobutyryl phosphate

0

-

2.7.2.3

ITP + 3-phospho-D-glycerate = IDP + 1,3-diphosphoglycerate

0

-

2.7.2.6

ITP + formate = IDP + formyl phosphate

0

-

2.7.4.1

ITP + (phosphate)n = IDP + (phosphate)n+1

0

-

2.7.4.10

GTP + IMP = GDP + IDP

0

-

2.7.4.10

ITP + AMP = IDP + ADP

0, 642534, 642538

-

2.7.4.14

ITP + CMP = IDP + CDP

0

-

2.7.4.14

ITP + UMP = IDP + UDP

0

-

2.7.4.10

2 entries

2.7.4.14

2 entries

2.7.4.2

ITP + 5-phosphomevalonate = IDP + 5-diphosphomevalonate

645176

-

2.7.4.25

ITP + CMP = IDP + CDP

0

-

2.7.4.3

ATP + IMP = ADP + IDP

0

-

2.7.4.3

ITP + AMP = IDP + ADP

0

-

2.7.4.33

IMP + (phosphate)n+1 = IDP + (phosphate)n

0

-

2.7.4.33

IMP + [phosphate]n = IDP + [phosphate]n-1

0

-

2.7.4.3

2 entries

2.7.4.33

2 entries

2.7.4.4

ITP + AMP = IDP + ADP

642628

-

2.7.4.6

ADP + ITP = ATP + IDP

0

6xpu, 3D-view

2.7.4.6

ITP + ADP = IDP + ATP

642652, 642628, 642655

6xpu, 3D-view

2.7.4.6

ITP + UDP = IDP + UTP

0

6xpu, 3D-view

2.7.4.6

3 entries

2.7.4.8

ATP + IMP = ADP + IDP

0

-

2.7.4.9

ATP + IMP = ADP + IDP

0

-

2.7.4.9

ITP + dTMP = IDP + dTDP

0

-

2.7.4.9

2 entries

2.7.4.B1

ATP + IMP = ADP + IDP

0

-

2.7.7.5

IDP + phosphate = phosphate + IDP

643453

-

2.7.7.5

phosphate + inosine 5'-phosphosulfate = IDP + SO42-

0

-

2.7.7.5

2 entries

3.1.3.2

ITP + H2O = IDP + phosphate

0

-

3.1.3.5

ITP + H2O = IDP + phosphate

0

-

3.1.3.9

glucose + ITP = glucose 6-phosphate + IDP

0

-

3.5.4.17

ADP + H2O = IDP + NH3

0

-

3.5.4.18

ADP + H2O = IDP + NH3

0

-

3.5.4.7

adenosine 5'-diphosphate + H2O = inosine 5'-diphosphate + NH3

0

-

3.5.4.7

adenosine diphosphate + H2O = inosine diphosphate + NH3

0

-

3.5.4.7

2 entries

3.6.1.15

ITP + H2O = IDP + phosphate

0

-

3.6.1.28

ITP + H2O = IDP + phosphate

0

-

3.6.1.5

ITP + H2O = IDP + phosphate

0

-

3.6.1.6

ITP + H2O = IDP + phosphate

0

-

3.6.1.62

dITP + H2O = IDP + phosphate

0

-

3.6.1.62

ITP + H2O = IDP + phosphate

0

-

3.6.1.62

2 entries

3.6.1.64

ITP + H2O = IDP + phosphate

0

-

3.6.1.66

ITP + H2O = IDP + phosphate

0

-

3.6.1.73

inosine 5'-triphosphate + H2O = inosine 5'-diphosphate + phosphate

0

-

3.6.1.9

ITP + H2O = IDP + phosphate

0

-

3.6.4.13

ITP + H2O = IDP + phosphate

0

-

3.6.5.3

ITP + H2O = IDP + phosphate

644150, 644152

-

3.6.5.6

ITP + H2O = IDP + phosphate

0

-

4.1.1.32

ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2

0, 649936, 4347, 649586, 652113, 649467, 653770, 650021

-

4.1.1.33

ITP + 5-diphosphomevalonate = IDP + phosphate + isopentenyl diphosphate + CO2

0

-

4.1.1.49

ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2

0

-

5.6.1.2

ITP + H2O + a dynein associated with a microtubule at position n = IDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)

247038

-

5.6.1.5

ITP + H2O + polypeptide = IDP + phosphate + unfolded polypeptide

0

-

5.6.1.7

ITP + H2O + a folded polypeptide = IDP + phosphate + an unfolded polypeptide

0

-

5.6.1.8

ITP + H2O + actin = IDP + phosphate + actin

0

-

5.6.1.8

ITP + H2O + myosin bound to actin filament at position n = IDP + phosphate + myosin bound to actin filament at position n+1

247003

-

5.6.1.8

2 entries

6.2.1.13

ITP + acetate + CoA = IDP + phosphate + acetyl-CoA

0

-

6.2.1.6

ITP + glutarate + CoA = IDP + phosphate + glutaryl-CoA

0

-

6.2.1.B11

ITP + acetate + CoA = IDP + phosphate + acetyl-CoA

0

-

6.3.1.2

ITP + L-Glu + NH4+ = IDP + phosphate + L-Gln

0

-

6.3.2.12

ITP + 7,8-dihydropteroate + L-Glu = IDP + phosphate + 7,8-dihydrofolate

0

-

6.3.2.17

ITP + 5,10-methylene-5,6,7,8-tetrahydropteroyl-Glu + Glu = IDP + phosphate + 5,10-methylene-5,6,7,8-tetrahydropteroyl-gamma-Glu2

1072

-

6.3.2.17

ITP + 5,6,7,8-tetrahydropteroyl-Glu + Glu = IDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2

0

-

6.3.2.17

2 entries

6.3.2.3

ITP + gamma-Glu-L-Cys + Gly = IDP + phosphate + glutathione

0

-

6.3.3.2

ITP + 5-formyltetrahydrofolate = IDP + phosphate + 5,10-methylenetetrahydrofolate

0

-

6.3.3.3

ITP + (7R,8S)-7,8-diaminopelargonic acid + NaHCO3 = IDP + phosphate + dethiobiotin + Na+ + OH-

0

-

6.3.3.3

ITP + 7,8-diaminononanoate + CO2 = IDP + phosphate + dethiobiotin

0

-

6.3.3.3

2 entries

6.3.4.21

nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ITP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + IDP + phosphate

0

-

6.3.4.4

ITP + IMP + L-Asp = IDP + phosphate + adenylosuccinate

1561, 0

-

6.3.4.4

ITP + IMP + L-aspartate = IDP + phosphate + adenylosuccinate

650258

-

6.3.4.4

2 entries

6.6.1.2

ITP + hydrogenobyrinic acid a,c-diamide + Co2+ = IDP + phosphate + cob(II)yrinic acid a,c-diamide + H+

653078

-

7.1.2.1

ITP + H2O + H+/in = IDP + phosphate + H+/out

0

-

7.1.2.2

ITP + H2O + H+/in = IDP + phosphate + H+/out

0, 210233, 210238

-

7.2.2.1

ITP + H2O + Na+/in = IDP + phosphate + Na+/out

0

-

7.2.2.10

ITP + H2O + Ca2+[side 1] = IDP + phosphate + Ca2+[side 2]

0

-

7.2.2.19

ITP + H2O + H+/in + K+/out = IDP + phosphate + H+/out + K+/in

246851, 0

-

Enzyme Cofactor/Cosubstrate (4 results)

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Show Cofactor (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.5.1

activation

391082

-

2.7.1.146

-

698924

-

4.1.1.32

stimulates Mn2+-dependent CO2-oxaloacetate exchange

4344

-

6.3.5.5

enhances activity

1731

-

Activator in Enzyme-catalyzed Reactions (4 results)

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Show Activating Compound (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.5.1

activation

391082

-

1.4.1.4

at 1 mM five-fold Michaelis Menten constant of 2-oxoglutarate

391669

-

2.7.11.31

-

644959

-

3.5.4.1

10.0 mM, relative activity 152%

209489

-

Inhibitor in Enzyme-catalyzed Reactions (27 results)

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Show Inhibitors (27 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.44

-

286830, 286840

-

2.3.1.44

30% inhibition at 1 mM

661291

-

2.4.1.152

potent inhibitor

349725

-

2.4.1.344

10 mM, 60-75% inhibition

740259

-

2.4.1.65

about 30% inhibition at 0.4 mM

735774

-

2.4.1.65

about 60% inhibition at 0.4 mM

735774

-

2.4.1.65

2 entries

2.4.1.68

-

680034

-

2.4.1.88

-

489482

-

2.4.2.14

5 mM, 29% inhibition

489757

-

2.4.2.19

2 mM, 29% inhibition

638018

-

2.4.2.8

-

638161, 638393

-

2.7.1.107

-

640355

-

2.7.1.113

1 mM, 58% inhibition at pH 6.0

640553

-

2.7.1.12

weak

640680

-

2.7.1.40

-

708992

-

2.7.2.1

preincubation of acetate kinase with MgCl2, AlCl3, NaF, acetate, and either IDP, UDP, or CDP in place of ADP results in almost complete inhibition of activity

727839

-

2.7.6.1

47% inhibition at 1 mM

642717

-

2.7.6.1

below 3-4 mM, linear competitive inhibition with respect to ATP

642718

-

2.7.6.1

2 entries

2.7.7.35

weak, ADPribose phosphorolysis

643246

-

2.7.7.59

inhibits uridylyl removing activity

643541

-

2.7.7.88

-

748511

-

3.1.3.5

-

95035

-

3.6.1.5

59% inhibition at 0.5 mM

696153

-

3.6.1.64

-

735030

-

4.1.1.49

inhibits exchange reaction with ATP or GTP

4636

-

6.3.4.21

-

637754

-

6.3.4.4

-

1539, 1548

-

3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (11 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.7.1.149

7em1, 3D-view

2.7.1.149

7em4, 3D-view

2.7.1.149

7em6, 3D-view

2.7.1.149

7em1, 3D-view

2.7.1.149

7em4, 3D-view

2.7.1.149

7em6, 3D-view

2.7.1.149

7em1, 3D-view

2.7.1.149

7em4, 3D-view

2.7.1.149

7em6, 3D-view

2.7.1.149

9 entries

2.7.4.6

6xpu, 3D-view

6.5.1.3

6tzx, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (12 results)

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Show Turnover Number (12 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.1.1.205

0.28

-

pH 8.0, 25°C

726097

1.1.1.205

1.4

-

pH 8.0, 22°C

724347

1.1.1.205

2 entries

2.7.1.40

131

-

PykII, in 100 mM Tris-HCl,pH 8.5, at 37°C

708992

3.1.3.2

60.4

-

pH 5.8, 30°C

694602

3.6.1.1

57.3

-

at pH 9.5 and 95°C

734503

3.6.1.15

0.06

-

substrate concentration between 0.01 and 4.0 mM, 37°C

696275

3.6.1.5

79.9

-

recombinant wild-type enzyme, pH 7.4, 25°C

720261

3.6.1.64

0.016

-

pH 7.5, 37°C

720583

3.6.1.9

88

-

pH 4.5, 37°C

730589

4.1.1.32

2.3

-

pH 7.4, 25°C, C306S mutant

649467

4.1.1.32

2.4

-

pH 7.4, 25°C, C306A mutant

649467

4.1.1.32

6.9

-

pH 7.4, 25°C, wild-type enzyme

649467

4.1.1.32

3 entries

K_M Value (42 results)

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Show KM Value (42 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.205

0.0082

-

pH 8.0, 25°C

726095

1.1.1.205

0.018

-

pH 8.0, 22°C

724347

1.1.1.205

0.03

-

pH 8.0, 25°C

726097

2.7.1.40

0.049

0.1

-

641589

2.7.1.40

0.049

0.1

25°C, pH 7.9

641567

2.7.1.40

0.049

0.1

cosubstrate phosphoenolpyruvate

641555, 641551, 641523, 641567, 641576, 641532, 641539, 641546

2.7.1.40

0.049

0.1

isozyme PKc

641576

2.7.1.40

0.193

-

PykII, in 100 mM Tris-HCl,pH 8.5, at 37°C

708992

2.7.1.40

4

-

isozyme PKp, 25°C, pH 7.9

641567

1.1.1.205

3 entries

2.7.1.40

6 entries

2.7.2.10

0.7

-

pH 7, 30°C

645109

3.1.3.2

0.23

-

pH 5.1, 25°C

651405

3.1.3.2

1.45

-

pH 5.8, 30°C

694602

3.1.3.2

2 entries

3.6.1.1

3.47

-

at pH 9.5 and 95°C

734503

3.6.1.15

0.046

-

substrate concentration between 0.01 and 4.0 mM, 37°C

696275

3.6.1.42

0.166

-

at pH 6.5 and 37°C

758117

3.6.1.5

0.0105

-

recombinant wild-type enzyme, pH 7.4, 25°C

720261

3.6.1.5

0.166

-

pH 6.5, 25°C

735003

3.6.1.5

0.622

-

pH 7.5, 37°C, presence of Mg2+

654862

3.6.1.6

0.48

-

native enzyme in presence of ATP

210211

3.6.1.6

0.54

-

in presence of Mn2+

210202

3.6.1.6

0.65

-

isoenzyme 1

656961

3.6.1.6

0.68

-

isoenzyme 2

656961

3.6.1.6

1.7

-

-

210206

3.6.1.6

2.94

-

native enzyme in absesence of ATP

210211

3.6.1.6

3.5

-

-

210208

3.6.1.5

3 entries

3.6.1.6

7 entries

3.6.1.64

0.062

-

pH 7.5, 37°C

720583

3.6.1.9

2.2

-

pH 4.5, 37°C

730589

4.1.1.32

0.013

-

-

4350

4.1.1.32

0.045

-

pH 7, in presence of 2.3 mM Mn2+

4357

4.1.1.32

0.046

-

in presence of 1 mM MnCl2 and 1 mM MgCl2

4369

4.1.1.32

0.0712

-

pH 7.0, 60°C

669085

4.1.1.32

0.0715

-

-

4347

4.1.1.32

0.1273

-

in Tris-HCl (50 mM, pH 7.4), temperature not specified in the publication

728430

4.1.1.32

0.182

-

-

4352

4.1.1.32

0.197

-

IDP in form of MnIDP-

4350

4.1.1.32

0.29

-

pH 7.2, 37°C

652113

4.1.1.32

0.3

-

pH 7.4, 25°C, wild-type enzyme

649467

4.1.1.32

0.4

-

-

4368

4.1.1.32

0.8

-

pH 6.3

4348

4.1.1.32

1.2

-

pH 7.4, 25°C, C306A mutant

649467

4.1.1.32

1.38

-

pH 7.4, 25°C, C306S mutant

649467

4.1.1.32

2.5

-

pH 7.2

4348

4.1.1.32

15 entries

K_i Value (4 results)

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Show KI Value (4 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.152

0.069

-

-

349725

2.4.1.68

2.4

-

-

680034

2.7.1.107

0.038

-

pH 7.5, 25°C

640355

2.7.7.88

0.0007

-

at pH 7.5 and 30°C

748511

IC₅₀ Value (1 result)

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Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

2.7.7.88

0.0064

-

at pH 7.5 and 30°C

748511

References & Links

Literature References (190)

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Show Reference (190 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

625

9119024

Purification and properties of acetyl-CoA synthetase (ADP-forming), an archaeal enzyme of acetate formation and ATP synthesis, from the hyperthermophile Pyrococcus furiosus

1997

Glasemacher, J.; Bock, A.K.; Schmid, R.; Schönheit, P.

Eur. J. Biochem.

244

561-567

627

13076

An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase

1977

Reeves, R.E.; Warren, L.G.; Susskind, B.; Lo, H.S.

J. Biol. Chem.

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726-731

1072

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Purification and properties of Lactobacillus casei folylpoly-gamma-glutamate synthetase

1983

Bognar, A.L.; Shane, B.

J. Biol. Chem.

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1539

7213642

Purification and properties of adenylosuccinate synthetase from Yoshida sarcoma ascites tumor cells

1980

Matsuda, Y.; Shimura, K.; Shiraki, H.; Nakagawa, H.

Biochim. Biophys. Acta

616

340-350

1548

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Human adenylosuccinate synthetase. Partial purification, kinetic and regulatory properties of the enzyme from placenta

1974

Van der Weyden, M.B.; Kelly, W.N.

J. Biol. Chem.

249

7282-7289

1561

7929056

Replacement of Asp333 with Asn by site-directed mutagenesis changes the substrate specificity of Escherichia coli adenylosuccinate synthetase from guanosine 5'-triphosphate to xanthosine 5'-triphosphate

1994

Kang, C.; Sun, N.; Honzatko, R.B.; Fromm, H.J.

J. Biol. Chem.

269

24046-24049

1731

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carbamyl phosphate synthetase (glutamine-utilizing) from Escherichia coli

1985

Kaseman, D.S.; Meister, A.

Methods Enzymol.

113

305-326

4344

5047708

Sheep kidney phosphoenolpyruvate carboxylase. Purification and properties

1972

Barns, R.J.; Keech, D.B.

Biochim. Biophys. Acta

276

284-296

4347

728402

Phosphoenolpyruvate carboxykinase (guanosine triphosphate) from rat liver cytosol. Separation of homogenous forms of the enzyme with high and low activity by chromatography on agarose-hexane-guanosine triphosphate

1978

Colombo, G.; Carlson, G.M.; Lardy, H.A.

Biochemistry

17

5321-5329

4348

314446

Purification and characterization of cytosol phosphoenolpyruvate carboxykinase from bullfrog (Rana catesbeiana) liver

1979

Goto, Y.; Shimizu, J.; Okazaki, T.; Shukuya, R.

J. Biochem.

86

71-78

4350

7068603

The purification, characterization, and activation of phosphoenolpyruvate carboxykinase from chicken liver mitochondria

1982

Hebda, C.A.; Nowak, T.

J. Biol. Chem.

257

5503-5514

4351

-

Subcellular location and some properties of phosphoenolpyruvate carboxykinase (PEPCK) in Euglena gracilis

1984

Miyatake, K.; Ito, T.; Kitaoka, S.

Agric. Biol. Chem.

48

2139-2141

4352

3759946

Purification and characteriation of phosphoenolpyruvate carboxykinase from the parasitic helminth Ascaris suum

1986

Rohrer, S.P.; Saz, H.J.; Nowak, T.

J. Biol. Chem.

261

13049-13055

4357

-

Purification, partial kinetic characterization and reactive sulfhydryl groups of the phosphoenolpyruvate carboxykinase from Perumytilus purpuratus adductor muscle

1995

Vial, M.V.; Oelckers, K.B.; Rojas, M.C.; Simpfendörfer, R.W.

Comp. Biochem. Physiol. B

112

451-460

4368

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Characterization of phosphoenolpyruvate carboxykinase from Corynebacterium glutamicum

1993

Jetten, M.S.M.; Sinskey, A.J.

FEMS Microbiol. Lett.

111

183-188

4369

-

Phosphoenolpyruvate carboxykinase from ribbed mussel gill tissue: reactivity with metal ions, kinetics, and action of 3-mercaptopicolinic acid

1991

Harlocker, S.L.; Kapper, M.A.; Greenwalt, D.E.; Bishop, S.H.

J. Exp. Zool.

257

285-298

4636

8577351

Phosphoenolpyruvate carboxykinase from Trypanosoma cruzi. Purification and physicochemical and kinetic properties

1995

Cymeryng, C.; Cazzulo, J.J.; Cannata, J.J.B.

Mol. Biochem. Parasitol.

73

91-101

95035

3001058

Human placental cytoplasmic 5'-nucleotidase. Kinetic properties and inhibition

1986

Madrid-Marina, V.; Fox, I.H.

J. Biol. Chem.

261

444-452

134710

-

Purification and molecular properties of an acid phosphatase from Asclepias curassavica latex

1986

Giordani, R.; Nari, J.; Noat, G.; Sauve, P.

Plant Sci.

43

207-212

209489

-

Kinetic properties of cytosine deaminase from Serratia marcescens

1976

Yu, T.; Sakai, T.; Omata, S.

Agric. Biol. Chem.

40

543-549

209778

6125457

Properties of apyrase and inorganic pyrophosphatase in Streptomyces aureofaciens

1982

Curdova, E.; Jechova, V.; Hostalek, Z.

Folia Microbiol. (Praha)

27

159-166

210055

10749145

Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with ras in activating extracellular signal-regulated kinase ERK1

2000

Recio, J.A.; Paez, J.G.; Maskeri, B.; Loveland, M.; Velasco, J.A.; Notario, V.

Cancer Res.

60

1720-1728

210132

2820077

Purification and partial characterization of adenosine diphosphatase activity in bovine aorta microsomes

1987

Miura, Y.; Hirota, K.; Arai, Y.; Yagi, K.

Thromb. Res.

46

685-695

210133

3010945

Salivary apyrase of Rhodnius prolixus. Kinetics and purification

1986

Sarkis, J.J.F.; GuimarÔes, J.A.; Ribeiro, J.M.C.

Biochem. J.

233

885-891

210141

6275835

Purification and characterization of a membrane-bound ATP diphosphohydrolase from Cicer arietinum (chick-pea) roots

1981

Vara, F.; Serrano, R.

Biochem. J.

197

637-643

210144

6243296

Characterization and purification of a calcium-sensitive ATP diphosphohydrolase from pig pancreas

1980

LeBel, D.; Poirier, G.G.; Phaneuf, S.; St-Jean, P.; Laliberte, J.F.; Beaudoin, A.R.

J. Biol. Chem.

255

1227-1233

210148

-

Purification, characterization, and localisation of an ATP diphosphohydrolase in porcine kidney

2000

Lemmens, R.; Kupers, L.; Sevigny, J.; Beaudoin, A.R.; Grondin, G.; Kittel, A.; Waelkens, E.; Vanduffel, L.

Am. J. Physiol.

278

978-988

210149

10681547

Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase

2000

Sevigny, J.; Robson, S.C.; Waelkens, E.; Csizmadia, E.; Smith, R.N.; Lemmens, R.

J. Biol. Chem.

275

5640-5647

210151

10231370

Functional characterization of rat ecto-ATPase and ecto-ATP diphosphohydrolase after heterologous expression in CHO cells

1999

Heine, P.; Braun, N.; Heilbronn, A.; Zimmermann, H.

Eur. J. Biochem.

262

102-107

210166

8177226

Characterization of an ATP diphosphohydrolase activity (apyrase EC 3.6.1.5) in rat blood platelets

1993

Frassetto, S.S.; Dias, R.D.; Sarkis, J.J.

Mol. Cell. Biochem.

129

47-55

210167

1477095

Kinetic properties of type-II ATP diphosphohydrolase from the tunica media of the bovine aorta

1992

Cote, Y.P.; Quellet, S.; Beaudoin, A.R.

Biochim. Biophys. Acta

1160

246-250

210202

2828050

Type B nucleoside-diphosphatase of rat brain. Purification and properties of an enzyme with high thiamin pyrophosphatase activity

1988

Sano, S.; Matsuda, Y.; Nakagawa, H.

Eur. J. Biochem.

171

231-236

210204

6320828

Thiamine pyrophosphatase and nucleoside diphosphatase in rat brain

1984

Sano, S.; Matsuda, Y.; Miyamoto, S.; Nakagawa, H.

Biochem. Biophys. Res. Commun.

118

292-298

210205

6293897

Comparative studies on nucleoside diphosphatase of rat ascites hepatoma and rat liver: activity level, purification and properties

1982

Ohkubo, I.; Taniguchi, N.; Mitsuyama, T.; Tsukada, Y.; Makita, A.

Int. J. Biochem.

14

1075-1081

210206

-

Rat brain nucleoside diphosphatase: purification and properties of type L isoenzyme

1994

Yang, W.J.; Kim, K.W.; Lee, B.J.

Arch. Pharm. Res.

17

256-262

210208

6256164

Purification and characterization of nucleoside diphosphatase from rat-liver microsomes. Evidence for metalloenzyme and glycoprotein

1980

Ohkubo, I.; Ishibashi, T.; Taniguchi, N.; Makita, A.

Eur. J. Biochem.

112

111-118

210209

6252848

Immobilization of nucleoside diphosphatase at its allosteric site using immobilized derivatives of pyridoxal 5 -phosphate

1980

Kawakita, N.; Yamazaki, M.

Arch. Biochem. Biophys.

204

326-330

210211

210795

Allosteric properties of nucleoside diphosphatase. Activation by pyridoxal 5'-phosphate and specific modification of effector binding sites

1978

Kawakita, N.; Yamazaki, M.

Biochem. J.

17

3546-3551

210213

210813

Affinity purification and some properties of nucleoside diphosphatase from rat liver cytosol

1978

Ishibashi, T.; Gasa, S.; Ohkubo, I.; Makita, A.

Biochim. Biophys. Acta

525

265-274

210216

4373445

Studies on mitochondrial and microsomal nucleoside diphosphatases of rat liver

1974

Shirasaka, T.; Arima, T.; Fujii, S.

J. Biochem.

76

99-106

210217

4354032

Nucleoside diphosphatase from pig liver: purification and some properties

1973

Pinsley, C.L.; Scrutton, M.C.

Arch. Biochem. Biophys.

158

331-345

210233

-

Mitochondrial and chloroplast ATPases

1974

Penefsky, H.S.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

10

375-429

210238

-

Bacterial membrane ATPase

1974

Abrams, A.; Smith, J.B.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

10

395-429

246808

12228543

Purification and properties of a unique nucleotide pyrophosphatase/phosphodiesterase I that accumulates in soybean leaves in response to fruit removal

1995

Salvucci, M.E.; Crafts-Brandner, S.J.

Plant Physiol.

108

1269-1276

246851

8594424

Characterization of Syrian hamster gastric mucosal H+,K+-ATPase

1995

Chatterjee, P.K.; Das, P.K.

Mol. Cell. Biochem.

148

95-103

247003

31357

Bovine platelet myosin. Properties of Mg- and Ca-ATPase

1978

Shimizu, T.

J. Biochem.

84

607-616

247038

20950

Interactions of Tetrahymena dyneins with microtubule protein. Tubulin-induced stimulation of dynein ATPase activity

1976

Hoshino, M.

Biochim. Biophys. Acta

462

49-62

286830

4358619

Sheep liver 6-phosphogluconate dehydrogenase. Inhibition by nucleoside phosphates and by other metabolic intermediates

1973

Dyson, J.E.D.; D'Orazio, R.E.

J. Biol. Chem.

248

5428-5435

286840

236441

6-Phospho-D-gluconate dehydrogenase from sheep liver

1975

Silverberg, M.; Dalziel, K.

Methods Enzymol.

41

214-220

347958

9602532

Purification and some properties of IMP dehydrogenase of Bacillus cereus

1998

Miyamoto, T.; Mtsuno, K.; Kim S.I.; Honjoh, K.I.; Hatano, S.

Microbiol. Res.

153

23-27

347963

10923792

Molecular cloning, overproduction and characterization of the Bacillus cereus IMP dehydrogenase

2000

Kim, S.I.; Miyamoto, T.; Jonjoh, K.I.; Hatano, S.

Biosci. Biotechnol. Biochem.

64

1210-1216

349725

8780523

Mechanism and specificity of human alpha-1,3-fucosyltransferase V

1996

Murray, B.W.; Takayama, S.; Schultz, J.; Wong, C.H.

Biochemistry

35

11183-11195

391082

-

The enzymes and the enzyme complexes of the mitochondrial oxidative phosphorylation system

1976

Hatefi, Y.

The Enzymes of Biological Membranes (Martonosi, A. V. , ed. ) Plenum, New York

4

3-41

391669

2901980

Trichomonas vaginalis: characterization of its glutamate dehydrogenase

1988

Turner, A.C.; Lushbaugh, W.B.

Exp. Parasitol.

67

47-53

437889

4542513

Ribonucleotide reductase from Thermus X-1, a thermophilic organism

1973

Sando, G.N.; Hogenkamp, H.P.C.

Biochemistry

12

3316-3322

487537

10074080

Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima

1999

Bock, A.K.; Glasemacher, J.; Schmidt, R.; Schonheit, P.

J. Bacteriol.

181

1861-1867

489482

19076

Solubilization and partial characterization of UDP-N-acetylgalactosamine: globoside alpha-N-acetylgalactosaminyltransferase from dog spleen microsomes

1977

Ishibashi, T.; Ohkubo, I.; Makita, A.

Biochim. Biophys. Acta

484

24-34

489757

4348202

Human glutamine phosphoribosylpyrophosphate amidotransferase. Kinetic and regulatory properties

1973

Holmes, E.W.; McDonald, J.A.; McCord, J.M.; Wyngaarden, J.B.; Kelley, W.N.

J. Biol. Chem.

248

144-150

637754

-

Purification and some properties of nicotinate phosphoribosyltransferase from hog liver

1984

Hayakawa, T.; Shibata, K.; Iwai, K.

Agric. Biol. Chem.

48

445-453

638018

-

Inhibition of hog liver crystalline quinolinate phosphoribosyltransferase by nucleotides, quinolinate analogues and sulfhydryl reagents

1976

Taguchi, H.; Iwai, K.

Agric. Biol. Chem.

40

385-389

638161

20306

Purification and comparative study of adenine and guanine phosphoribosyltransferases from Schizosaccharomyces pombe

1977

Nagy, M.; Ribet, A.M.

Eur. J. Biochem.

77

77-85

638393

-

Purification and properties of hypoxanthine phosphoribosyltransferase from Streptomyces cyanogenus

1980

Ohe, T.; Watanabe, Y.

Agric. Biol. Chem.

44

1999-2006

640355

16668739

Diacylglycerol kinase from suspension cultured plant cells

1992

Wissing, J.B.; Wagner, K.G.

Plant Physiol.

98

1148-1153

640421

-

Phosphofructokinase

1973

Bloxham, D.P.; Lardy, H.A.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

8

239-278

640426

-

Properties of phosphofructokinase from carp, eel and rainbow trout liver

1989

Nagashima, K.; Nakagawa, T.; Nagayama, F.

Nippon Suisan Gakkaishi

55

897-903

640436

-

Phosphofructokinase from Lycopersicon esculentum fruits-I. Kinetic properties in relation to its substrates

1986

Isaac, J.E.; Rhodes, M.J.C.

Phytochemistry

25

339-343

640443

-

Properties of the phosphofructokinase isoenzymes from germinating cucumber seeds

1988

Cawood, M.E.; Botha, F.C.; Small, J.G.C.

J. Plant Physiol.

132

204-209

640446

16666958

Cytosolic phosphofructokinase from spinach leaves: 2. The roles of magnesium and ATP

1989

Hausler, R.E.; Holtum, J.A.M.; Latzko, E.

Plant Physiol.

90

1506-1512

640463

6218375

Phosphofructokinases from Escherichia coli

1982

Kotlarz, D.; Buc, H.

Methods Enzymol.

90

60-70

640483

4242639

D-fructose 1-phosphate kinase and D-fructose 6-phosphate kinase from Aerobacter aerogenes. A comparative study of regulatory properties

1969

Sapico, V.; Anderson, R.L.

J. Biol. Chem.

244

6280-6288

640485

-

Phosphofructokinase from Clostridium pasteurianum

1975

Uyeda, K.; Kurooka, S.

Methods Enzymol.

42C

86-91

640495

242298

Catabolism of D-fructose and D-ribose by Pseudomonas doudoroffii. II. Properties of 1-phosphofructokinase and 6-phosphofructokinase

1975

Baumann, L.; Baumann, P.

Arch. Microbiol.

105

241-248

640509

10795681

Purification and properties of the first-identified, archaeal, ATP-dependent 6-phosphofructokinase, an extremely thermophilic non-allosteric enzyme, from the hyperthermophile Desulfurococcus amylolyticus

2000

Hansen, T.; Schonheit, P.

Arch. Microbiol.

173

103-109

640513

11797046

Sequence, expression, and characterization of the first archaeal ATP-dependent 6-phosphofructokinase, a non-allosteric enzyme related to the phosphofructokinase-B sugar kinase family, from the hyperthermophilic crenarchaeote Aeropyrum pernix

2001

Hansen, T.; Schonheit, P.

Arch. Microbiol.

177

62-69

640515

11976749

ATP-dependent 6-phosphofructokinase from the hyperthermophilic bacterium Thermotoga maritima: characterization of an extremely thermophilic, allosterically regulated enzyme

2002

Hansen, T.; Musfeldt, M.; Schonheit, P.

Arch. Microbiol.

177

401-409

640518

12721855

Purification and characterization of pyrophosphate- and ATP-dependent phosphofructokinases from banana fruit

2003

Turner, W.L.; Plaxton, W.C.

Planta

217

113-121

640553

6295492

Deoxyguanosine kinase from human placenta

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