Ligand IDP

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Basic Ligand Information

Molecular Structure
Picture of IDP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H14N4O11P2
IDP
JPXZQMKKFWMMGK-KQYNXXCUSA-N
Synonyms:
Inosine 5'-diphosphate, Inosine diphosphate


Show all pahtways known for Show all BRENDA pathways known for IDP

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
inosine 5'-diphosphate + NAD+ + H2O = xanthosine 5'-diphosphate + NADH + H+
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IDP + H2O = IMP + phosphate
show the reaction diagram
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IDP + H2O = IMP + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
adenosine diphosphate + H2O = inosine diphosphate + NH3
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ITP + H2O = IDP + phosphate
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inosine 5'-triphosphate + H2O = inosine 5'-diphosphate + phosphate
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (28 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
IDP + reduced thioredoxin = dIDP + oxidized thioredoxin
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D-fructose 6-phosphate + IDP = D-fructose 1,6-bisphosphate + IMP
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IDP + phosphoenolpyruvate = ITP + pyruvate
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IDP + phosphoramide = ITP + NH3
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dATP + IDP = dADP + ITP
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IDP + phosphate = phosphate + IDP
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poly(I) + IDP = poly(I)+1 + phosphate
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IDP + H2O = ?
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IDP + H2O = ?
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IDP + H2O = IMP + phosphate
show the reaction diagram
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IDP + H2O = IMP + phosphate
show the reaction diagram
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IDP + H2O = IMP + phosphate
show the reaction diagram
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IDP + H2O = IMP + phosphate
show the reaction diagram
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IDP + phosphoenolpyruvate + CO2 = ITP + oxaloacetate
show the reaction diagram
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IDP + H2O + a folded polypeptide = IMP + phosphate + an unfolded polypeptide
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IDP + phosphate + acetyl-CoA = ITP + acetate + CoA
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IDP + phosphate + Na+/out = ITP + H2O + Na+/in
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Product in Enzyme-catalyzed Reactions (122 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
IDP-glucose + D-fructose = IDP + sucrose
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ITP + D-glucose = IDP + D-glucose 6-phosphate
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ITP + beta-D-fructose 6-phosphate = IDP + beta-D-fructose 2,6-bisphosphate
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ITP + sn-1,2-dihexanoylglycerol = IDP + sn-1,2-dihexanoylglycerol 3-phosphate
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ITP + D-fructose 6-phosphate = IDP + D-fructose 1,6-bisphosphate
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ITP + D-gluconate = IDP + 6-phospho-D-gluconate
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ITP + D-tagatose 6-phosphate = IDP + D-tagatose 1,6-bisphosphate
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ITP + D-ribose = IDP + D-ribose 5-phosphate
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ITP + N-acetyl-alpha-D-galactosamine = IDP + N-acetyl-alpha-D-galactosamine 1-phosphate
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ITP + N-acetyl-alpha-D-glucosamine = IDP + N-acetyl-alpha-D-glucosamine 1-phosphate
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ITP + L-seryl-tRNASec = IDP + O-phospho-L-seryl-tRNASec
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ITP + dibekacin = IDP + dibekacin 2''-phosphate
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ITP + D-glucose = IDP + D-glucose 6-phosphate
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ITP + adenosine = IDP + AMP
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ITP + 2-deoxy-D-ribose = IDP + 2-deoxy-D-ribose 5-phosphate
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ITP + NAD+ = IDP + NADP+
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ITP + D-glyceraldehyde = IDP + D-glyceraldehyde-3-phosphate
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ITP + dihydroxyacetone = IDP + dihydroxyacetone phosphate
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ITP + glycerol = IDP + glycerol 3-phosphate
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ITP + pantothenate = IDP + D-4'-phosphopantothenate
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ITP + D-fructose = IDP + D-fructose 6-phosphate
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ITP + D-glucuronate = IDP + 1-phospho-D-glucuronate
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ITP + 2-dehydro-3-deoxy-D-gluconate = IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
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ITP + uridine = IDP + UMP
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ITP + 6-deoxy-L-galactose = IDP + 6-deoxy-L-galactose 1-phosphate
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ITP + D-arabinose = IDP + D-arabinose 5-phosphate
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ITP + D-fructose 1-phosphate = IDP + D-fructose 1,6-bisphosphate
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ITP + N-acetyl-D-glucosamine = IDP + N-acetyl-D-glucosamine 6-phosphate
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ITP + D-galactose = IDP + alpha-D-galactose 1-phosphate
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ITP + D-glucose = IDP + D-glucose 6-phosphate
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ITP + 1-phosphatidyl-1D-myo-inositol = IDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
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ITP + ethanolamine = IDP + O-phosphoethanolamine
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ITP + cellobiose = IDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose
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ITP + NADH = IDP + NADPH
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ITP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = IDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
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ITP + acetate = IDP + acetyl phosphate
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ITP + 3-phospho-D-glycerate = IDP + 3-phospho-D-glyceroyl 1-phosphate
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ITP + isobutanoate = IDP + isobutanoyl phosphate
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ITP + 3-phospho-D-glycerate = IDP + 1,3-diphosphoglycerate
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ITP + formate = IDP + formyl phosphate
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ITP + (phosphate)n = IDP + (phosphate)n+1
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ITP + 5-phosphomevalonate = IDP + 5-diphosphomevalonate
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ITP + CMP = IDP + CDP
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ITP + AMP = IDP + ADP
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ATP + IMP = ADP + IDP
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ATP + IMP = ADP + IDP
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ITP + H2O = IDP + phosphate
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ITP + H2O = IDP + phosphate
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glucose + ITP = glucose 6-phosphate + IDP
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ADP + H2O = IDP + NH3
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ADP + H2O = IDP + NH3
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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inosine 5'-triphosphate + H2O = inosine 5'-diphosphate + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + H2O = IDP + phosphate
show the reaction diagram
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ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2
show the reaction diagram
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ITP + 5-diphosphomevalonate = IDP + phosphate + isopentenyl diphosphate + CO2
show the reaction diagram
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ITP + oxaloacetate = IDP + phosphoenolpyruvate + CO2
show the reaction diagram
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ITP + H2O + a dynein associated with a microtubule at position n = IDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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ITP + H2O + polypeptide = IDP + phosphate + unfolded polypeptide
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ITP + H2O + a folded polypeptide = IDP + phosphate + an unfolded polypeptide
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ITP + acetate + CoA = IDP + phosphate + acetyl-CoA
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ITP + glutarate + CoA = IDP + phosphate + glutaryl-CoA
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ITP + acetate + CoA = IDP + phosphate + acetyl-CoA
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ITP + L-Glu + NH4+ = IDP + phosphate + L-Gln
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ITP + 7,8-dihydropteroate + L-Glu = IDP + phosphate + 7,8-dihydrofolate
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ITP + gamma-Glu-L-Cys + Gly = IDP + phosphate + glutathione
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ITP + 5-formyltetrahydrofolate = IDP + phosphate + 5,10-methylenetetrahydrofolate
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nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ITP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + IDP + phosphate
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ITP + hydrogenobyrinic acid a,c-diamide + Co2+ = IDP + phosphate + cob(II)yrinic acid a,c-diamide + H+
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ITP + H2O + H+/in = IDP + phosphate + H+/out
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ITP + H2O + H+/in = IDP + phosphate + H+/out
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ITP + H2O + Na+/in = IDP + phosphate + Na+/out
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ITP + H2O + Ca2+[side 1] = IDP + phosphate + Ca2+[side 2]
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ITP + H2O + H+/in + K+/out = IDP + phosphate + H+/out + K+/in
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Enzyme Cofactor/Cosubstrate (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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stimulates Mn2+-dependent CO2-oxaloacetate exchange
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enhances activity
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activation
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at 1 mM five-fold Michaelis Menten constant of 2-oxoglutarate
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10.0 mM, relative activity 152%
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Inhibitor in Enzyme-catalyzed Reactions (27 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
30% inhibition at 1 mM
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potent inhibitor
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10 mM, 60-75% inhibition
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5 mM, 29% inhibition
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2 mM, 29% inhibition
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1 mM, 58% inhibition at pH 6.0
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weak
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preincubation of acetate kinase with MgCl2, AlCl3, NaF, acetate, and either IDP, UDP, or CDP in place of ADP results in almost complete inhibition of activity
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weak, ADPribose phosphorolysis
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inhibits uridylyl removing activity
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59% inhibition at 0.5 mM
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inhibits exchange reaction with ATP or GTP
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (12 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
131
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PykII, in 100 mM Tris-HCl,pH 8.5, at 37°C
60.4
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pH 5.8, 30°C
57.3
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at pH 9.5 and 95°C
0.06
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substrate concentration between 0.01 and 4.0 mM, 37°C
79.9
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recombinant wild-type enzyme, pH 7.4, 25°C
0.016
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pH 7.5, 37°C
88
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pH 4.5, 37°C

KM Value (42 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.7
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pH 7, 30°C
3.47
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at pH 9.5 and 95°C
0.046
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substrate concentration between 0.01 and 4.0 mM, 37°C
0.166
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at pH 6.5 and 37°C
0.062
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pH 7.5, 37°C
2.2
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pH 4.5, 37°C

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.069
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2.4
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0.038
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pH 7.5, 25°C
0.0007
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at pH 7.5 and 30°C

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0064
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at pH 7.5 and 30°C

References & Links

Links to other databases for IDP

ChEBI
PubChem
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PubChem