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An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes
1987
Busby, W.H.; Quackenbush, G.E.; Humm, J.; Youngblood, W.W.; Kizer, J.S.
J. Biol. Chem.
262
8532-8536
Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides
1987
Fischer, W.H.; Spiess, J.
Proc. Natl. Acad. Sci. USA
84
3628-3632
Papaya glutamine cyclase, a plant enzyme highly resistant to proteolysis, adopts an all-b conformation
1998
Oberg, K.A.; Ruysschaert, J.M.; Azarkan, M.; Smolders, N.; Zerhouni, S.; Wintjens, R.; Amrani, A.; Looze, Y.
Eur. J. Biochem.
258
214-222
Steady-state kinetics of glutamine cyclotransferase
1994
Gololobov, M.Y.; Song, I.; Wang, W.; Bateman, R.C.M.
Arch. Biochem. Biophys.
309
300-307
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity
2002
Schilling, S.; Hoffmann, T.; Rosche, F.; Manhart, S.; Wasternack, C.; Demuth, H.U.
Biochemistry
41
10849-10857
Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding
2014
Huang, K.F.; Hsu, H.L.; Karim, S.; Wang, A.H.
Acta Crystallogr. Sect. D
70
789-801
Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers
2015
Seifert, F.; Demuth, H.U.; Weichler, T.; Ludwig, H.H.; Tittmann, K.; Schilling, S.
Bioorg. Chem.
60
98-101
Molecular characterization of tick salivary gland glutaminyl cyclase
2013
Adamson, S.W.; Browning, R.E.; Chao, C.C.; Bateman, R.C.; Ching, W.M.; Karim, S.
Insect Biochem. Mol. Biol.
43
781-793
Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC
2014
Hoefling, C.; Indrischek, H.; Hoepcke, T.; Waniek, A.; Cynis, H.; Koch, B.; Schilling, S.; Morawski, M.; Demuth, H.U.; Rossner, S.; Hartlage-Ruebsamen, M.
Int. J. Dev. Neurosci.
36
64-73
Glutaminyl cyclase activity correlates with levels of Abeta peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimers disease patients
2017
Bridel, C.; Hoffmann, T.; Meyer, A.; Durieux, S.; Koel-Simmelink, M.A.; Orth, M.; Scheltens, P.; Lues, I.; Teunissen, C.E.
Alzheimers Res. Ther.
9
38
Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study
2019
Bender, P.; Egger, A.; Westermann, M.; Taudte, N.; Sculean, A.; Potempa, J.; Moeller, B.; Buchholz, M.; Eick, S.
Arch. Oral Biol.
97
223-230
Inhibitory effect of flavonoids on human glutaminyl cyclase
2016
Li, M.; Dong, Y.; Yu, X.; Zou, Y.; Zheng, Y.; Bu, X.; Quan, J.; He, Z.; Wu, H.
Bioorg. Med. Chem.
24
2280-2286
Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors
2018
Ngo, V.T.H.; Hoang, V.H.; Tran, P.T.; Van Manh, N.; Ann, J.; Kim, E.; Cui, M.; Choi, S.; Lee, J.; Kim, H.; Ha, H.J.; Choi, K.; Kim, Y.H.; Lee, J.
Bioorg. Med. Chem.
26
3133-3144
Identification of glutaminyl cyclase isoenzyme isoQC as a regulator of SIRPalpha-CD47 axis
2019
Wu, Z.; Weng, L.; Zhang, T.; Tian, H.; Fang, L.; Teng, H.; Zhang, W.; Gao, J.; Hao, Y.; Li, Y.; Zhou, H.; Wang, P.
Cell Res.
29
502-505
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The development of small molecule inhibitors of glutaminyl cyclase and isoglutaminyl cyclase for Alzheimers disease
2019
Xu, A.; He, F.; Yu, C.; Qu, Y.; Zhang, Q.; Lv, J.; Zhang, X.; Ran, Y.; Wei, C.; Wu, J.
ChemistrySelect
4
10591-10600
Dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation
2018
Schlenzig, D.; Cynis, H.; Hartlage-Ruebsamen, M.; Zeitschel, U.; Menge, K.; Fothe, A.; Ramsbeck, D.; Spahn, C.; Wermann, M.; Rossner, S.; Buchholz, M.; Schilling, S.; Demuth, H.U.
J. Alzheimers Dis.
66
359-375
The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders
2018
Pozzi, C.; Di Pisa, F.; Benvenuti, M.; Mangani, S.
J. Biol. Inorg. Chem.
23
1219-1226
Cone snail glutaminyl cyclase sequences from transcriptomic analysis and mass spectrometric characterization of two pyroglutamyl conotoxins
2018
Vijayasarathy, M.; Basheer, S.M.; Balaram, P.
J. Proteome Res.
17
2695-2703
Natural products from microalgae with potential against Alzheimers disease sulfolipids are potent glutaminyl cyclase inhibitors
2016
Hielscher-Michael, S.; Griehl, C.; Buchholz, M.; Demuth, H.U.; Arnold, N.; Wessjohann, L.A.
Mar. Drugs
14
203
Immunohistochemical evidence from APP-transgenic mice for glutaminyl cyclase as drug target to diminish pE-Abeta formation
2018
Hartlage-Ruebsamen, M.; Bluhm, A.; Piechotta, A.; Linnert, M.; Rahfeld, J.U.; Demuth, H.U.; Lues, I.; Kuhn, P.H.; Lichtenthaler, S.F.; Rossner, S.; Hoefling, C.
Molecules
23
924
Glutaminyl cyclase is an enzymatic modifier of the CD47-SIRPalpha axis and a target for cancer immunotherapy
2019
Logtenberg, M.E.W.; Jansen, J.H.M.; Raaben, M.; Toebes, M.; Franke, K.; Brandsma, A.M.; Matlung, H.L.; Fauster, A.; Gomez-Eerland, R.; Bakker, N.A.M.; van der Schot, S.; Marijt, K.A.; Verdoes, M.; Haanen, J.B.A.G.; van den Berg, J.H.; Neefjes, J.; van den Berg, T.K.; Brummelkamp, T.R.; Leusen, J.H.W.; Scheeren, F.A.; Schumacher, T.N.
Nat. Med.
25
612-619
Human glutaminyl cyclase Structure, function, inhibitors and involvement in Alzheimers disease
2019
Vijayan, D.K.; Zhang, K.Y.J.
Pharmacol. Res.
147
104342
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In vitro and in silico determination of glutaminyl cyclase inhibitors
2019
Tran, P.; Hoang, V.; Lee, J.; Hien, T.; Tung, N.; Ngo, S.
RSC Adv.
9
29619-29627
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