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Ligand GDP-fucose

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.221

GDP-fucose + TSR4 = GDP + fucosyl-TSR4

722118

-

2.4.1.65

GDP-fucose + Gal-beta-1,4GlcNAc-beta-1-R = GDP + Gal-beta-1,4(fuc-alpha-1,3)GlcNAc-beta-1-R

661341

-

2.4.1.69

GDP-fucose + Galbeta1-4Glc = Fucalpha1-2Galbeta1-4Glc + GDP

677551

-

2.4.1.69

GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc = Fucalpha1-2Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + GDP

677551

-

2.4.1.69

2 entries

Substrate in Enzyme-catalyzed Reactions (112 results)

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Show Substrate (112 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.152

GDP-fucose + (-3GalNAcbeta1-4GlcNAcbeta1-)n = GDP + (-3GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-)n

659454

-

2.4.1.152

GDP-fucose + (Galbeta1-4Galbeta1-4GlcNAcbeta1-2Manalpha1-6[Galbeta1-4Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-3])Manbeta1-4GlcNAc = GDP + (Galbeta1-4Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-6[Galbeta1-4Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-3])Manbeta1-4GlcNAc

687445

-

2.4.1.152

GDP-fucose + (Galbeta1-4Galbeta1-4GlcNAcbeta1-2Manalpha1-6[Galbeta1-4Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-3])Manbeta1-4GlcNAcbeta1-4GlcNAc = GDP + (Galbeta1-4Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-6[GalbetaGalbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-3])Manbeta1-4GlcNAcbeta1-4GlcNAc

687445

-

2.4.1.152

GDP-fucose + asialo human erythropoietin = GDP + fucosylated asialo human erythropoietin

685736

-

2.4.1.152

GDP-fucose + bovine asialofetuin = GDP + fucosylated bovine asialofetuin

685736

-

2.4.1.152

GDP-fucose + Fucalpha1-2Galbeta1-4GlcNAc = GDP + Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAc

349722, 349723

-

2.4.1.152

GDP-fucose + Fucalpha1-2Galbeta1-4GlcNAc-O-(CH2)3NHCO(CH2)5-NH-biotin = GDP + Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAc-O-(CH2)3NHCO(CH2)5-biotin

685736

-

2.4.1.152

GDP-fucose + Fucalpha1-2Galbeta1-4GlcNAcbeta1-R = GDP + Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-R

687115

-

2.4.1.152

GDP-fucose + Galbeta(1,3)GlcNAcOMe = GDP + Galbeta(1,4)(Fucalpha(1,3))GlcNAcOMe

658279

-

2.4.1.152

GDP-fucose + Galbeta1-4Glc = GDP + Galbeta1-4 (Fucalpha1-3)Glc

349722

-

2.4.1.152

GDP-fucose + Galbeta1-4Glc-NAc-O-(CH2)3NHCO(CH2)5-NH-biotin = GDP + Galbeta1-4(Fucalpha1-3)GlcNAc-O-(CH2)3NHCO(CH2)5-NH-biotin

685736

-

2.4.1.152

GDP-fucose + Galbeta1-4GlcNAc = GDP + Galbeta1-4 (Fucalpha1-3)GlcNAc

349722

-

2.4.1.152

GDP-fucose + Galbeta1-4GlcNAc-O-(CH2)3NHCO(CH2)5-NH-biotin = GDP + Galbeta1-4(Fucalpha1-3)GlcNAc-O-(CH2)3NHCO(CH2)5-NH-biotin

685736

-

2.4.1.152

GDP-fucose + Galbeta1-4GlcNAc-R = GDP + Galbeta1-4(Fucalpha1-3)GlcNAc-R

349727, 349726

-

2.4.1.152

GDP-fucose + Galbeta1-4GlcNAcbeta1-2Manalpha1-6(Galbeta1-4GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn = GDP + Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-6(Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn

671893

-

2.4.1.152

GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc-PA = GDP + Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc-PA

671893

-

2.4.1.152

GDP-fucose + GalNAcbeta1-4GlcNAcbeta-R = GDP + GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-R

659454

-

2.4.1.152

GDP-fucose + GalNAcbeta1-4GlcNAcbeta1-2Manalpha1-6(GalNAcbeta1-4GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn = GDP + GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-6(GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn

671893

-

2.4.1.152

GDP-fucose + GalNAcbeta1-4GlcNAcbeta1-3Galbeta1-4Glc = GDP + GalNAcbeta1-4[Fucalpha1-3]GlcNAcbeta1-3Galbeta1-4Glc

349727

-

2.4.1.152

GDP-fucose + GalNAcbeta1-4GlcNAcbeta1-R = GDP + GalNAcbeta1-4[Fucalpha1-3]GlcNAcbeta1-R

349727

-

2.4.1.152

GDP-fucose + human erythropoietin = GDP + fucosylated human erythropoietin

685736

-

2.4.1.152

GDP-fucose + LacNAc = GDP + ?

349725

-

2.4.1.152

GDP-fucose + LacNAcbeta-O-(CH2)5CO2CH3 = GDP + ?

349725

-

2.4.1.152

GDP-fucose + lacto-N-neotetraose = GDP + ?

349723

-

2.4.1.152

GDP-fucose + lacto-N-neotetraose = GDP + lacto-N-fucopentaose III

349727, 349726

-

2.4.1.152

GDP-fucose + methyl beta-D-2-O-methylgalactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose = GDP + methyl beta-D-2-O-methylgalactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-2-O-methylgalactosyl-(1-4)-6-O-methyl-N-acetyl-beta-D-glucosamine = GDP + methyl beta-D-2-O-methylgalactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-6-O-methyl-N-acetyl-beta-D-glucosamine

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-2-O-methylgalactosyl-(1-4)-N-acetyl-beta-D-glucosamine = GDP + methyl beta-D-2-O-methylgalactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-N-acetyl-beta-D-glucosamine

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-acetylamino-beta-D-glucopyranose = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-acetylamino-beta-D-glucopyranose

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-amino-beta-D-glucopyranose = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-amino-beta-D-glucopyranose

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-formylamino-beta-D-glucopyranose

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-6-deoxy-6-methylsulfonylamino-beta-D-glucopyranose = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-6-deoxy-6-methylsulfonylamino-beta-D-glucopyranose

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl amide = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl amide

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl ester = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-2-deoxy-2-acetylamino-beta-D-glucopyranosiduronic acid methyl ester

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-6-O-methyl-N-acetyl-beta-D-glucosamine = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-6-O-methyl-N-acetyl-beta-D-glucosamine

658279

-

2.4.1.152

GDP-fucose + methyl beta-D-galactosyl-(1-4)-6-O-methylsulfonyl-N-acetyl-beta-D-glucosamine = GDP + methyl beta-D-galactosyl-(1-4)-[alpha-D-fucosyl-(1-3)]-6-O-methylsulfonyl-N-acetyl-beta-D-glucosamine

658279

-

2.4.1.152

GDP-fucose + NeuAcalpha2-3Galbeta1-4GlcNAc = GDP + NeuAcalpha2-3Galbeta1-4(Fucalpha1-3)GlcNAc

349723, 349727, 349726

-

2.4.1.152

GDP-fucose + sialyl-alpha-2,3-N-acetyllactosamine = GDP + NeuNAcalpha2-3Galbeta1-4[Fucalpha1-3]GlcNAc

673753

-

2.4.1.214

GDP-fucose + alpha1-acid glycoprotein = GDP + alpha1-3 fucosylated glycoprotein

349721

-

2.4.1.214

GDP-fucose + asialo-alpha1-acid glycoprotein = GDP + alpha1-3 fucosylated glycoprotein

349721

-

2.4.1.214

GDP-fucose + asialo/agalacto-glycopeptide-F2 = GDP + alpha1-3-fucosylated glycopeptide

349718

-

2.4.1.214

GDP-fucose + asialo/agalacto-glycopeptide-IgGF6 = GDP + alpha1-3-fucosylated glycopeptide

349718

-

2.4.1.214

GDP-fucose + asialofetuin = GDP + alpha1-3 fucosylated glycoprotein

349721

-

2.4.1.214

GDP-fucose + asialotransferrin = GDP + alpha1-3 fucosylated glycoprotein

349721

-

2.4.1.214

GDP-fucose + bisected agalacto-glycopeptide-IgGF6 = GDP + alpha1-3-fucosylated glycopeptide

349718

-

2.4.1.214

GDP-fucose + dabsyl-GnGn-peptide = GDP + alpha1-3-fucosylated dabsyl-GnGn-peptide

349716, 349715

-

2.4.1.214

GDP-fucose + dabsylated-GalGal-peptide = GDP + alpha1-3-fucosylated peptide

349717

-

2.4.1.214

GDP-fucose + dabsylated-GalGn-peptide = GDP + alpha1-3-fucosylated peptide

349717

-

2.4.1.214

GDP-fucose + dansyl-GnGn = GDP + alpha1-3-fucosylated glycopeptide

349716, 349715

-

2.4.1.214

GDP-fucose + dansyl-GnGnF6 = GDP + alpha1-3-fucosylated glycopeptide

349716

-

2.4.1.214

GDP-fucose + dansylated mono-beta1,3-galactosylated glycopeptide = GDP + alpha1-3-fucosylated glycopeptide

349715

-

2.4.1.214

GDP-fucose + fetuin = GDP + alpha1-3 fucosylated glycoprotein

349721

-

2.4.1.214

GDP-fucose + Galbeta1-4GlcNAcalpha-p-nitrophenol = Galbeta1-4(Fucalpha1-3)GlcNAcalpha-p-nitrophenol

686972

-

2.4.1.214

GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc = GDP + Galbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc

686972

-

2.4.1.214

GDP-fucose + GalGal-N-glycan = GDP + alpha1-3-fucosylated GalGal-N-glycan

349716

-

2.4.1.214

GDP-fucose + GalGalF6-N-glycan = GDP + alpha1-3-fucosylated GalGalF6-N-glycan

349716

-

2.4.1.214

GDP-fucose + GalNAcbeta1-4GlcNAcbeta1-3Galbeta1-4Glc = GalNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-3Galbeta1-4Glc

686972

-

2.4.1.214

GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn = GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-Asn

349717

-

2.4.1.214

GDP-fucose + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn = GDP + GlcNAcbeta1-2-Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn

349717

-

2.4.1.214

GDP-fucose + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4GlcNAcbeta1-Asn = GDP + GlcNAcbeta1-2-Manalpha1-3[Manalpha1-3(Manalpha1-6)Manalpha1-6]Manbeta1-4-GlcNAcbeta1-4 (Fucalpha1-3)GlcNAcbeta1-Asn

349717

-

2.4.1.214

GDP-fucose + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-N-Asn-peptide(Nac) = GDP + GlcNAcbeta1-2-Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcbeta1-N-Asn-peptide(Nac)

349719

-

2.4.1.214

GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn = GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)[Fucalpha1-6]GlcNAcbeta1-Asn

671893

-

2.4.1.214

GDP-fucose + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-Asn = GDP + GlcNAcbeta1-2Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn

671893

-

2.4.1.214

GDP-fucose + GnGn-oligosaccharide = GDP + alpha1-3 fucosylated GnGn-oligosaccharide

349724

-

2.4.1.214

GDP-fucose + GnGn-peptide = GDP + alpha1-3 fucosylated peptide

349724

-

2.4.1.214

GDP-fucose + GnGn-peptide = GDP + alpha1-3-fucosylated peptide

349717

-

2.4.1.214

GDP-fucose + GnGnF6-oligosaccharide = GDP + alpha1-3 fucosylated oligosaccharide

349724

-

2.4.1.214

GDP-fucose + GnGnF6-peptide = GDP + alpha1-3-fucosylated GnGnF6-peptide

349717, 349724

-

2.4.1.214

GDP-fucose + M5Gn-Asn = GDP + alpha1-3-fucosylated M5Gn-Asn

349717

-

2.4.1.214

GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)GlcNAcbeta1-Asn = Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-6)(Fucalpha1-3)GlcNAcb1-Asn

686972

-

2.4.1.214

GDP-fucose + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAcbeta1-Asn = GDP + Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-Asn

686972

-

2.4.1.214

GDP-fucose + N-acetyllactosamine = GDP + 3-fucosyl-N-acetyllactosamine

672191

-

2.4.1.214

GDP-fucose + N-acetyllactosamine = GDP + Galbeta1-4(Fucalpha1-3)GlcNAc

687684

-

2.4.1.214

GDP-fucose + N-[2-(2-pyridylamino)ethyl]-succinamic acid-labeled biantennary oligosaccharides = GDP + ?

757946

-

2.4.1.214

GDP-fucose + transferrin = GDP + alpha1-3 fucosylated glycoprotein

349721

-

2.4.1.221

GDP-fucose + TSR1 = GDP + fucosyl-TSR1

722369

-

2.4.1.221

GDP-fucose + TSR2 = GDP + fucosyl-TSR2

722369

-

2.4.1.221

GDP-fucose + TSR3 = GDP + fucosyl-TSR3

722369

-

2.4.1.221

GDP-fucose + TSR4 = GDP + fucosyl-TSR4

722118

-

2.4.1.65

GDP-fucose + 2-aminopyridino-lacto-N-tetraose = GDP + 2-aminopyridino-lacto-N-fucopentaose II

757939

-

2.4.1.65

GDP-fucose + 2-O-MeGal-beta-1,3GlcNAc = GDP + 2-O-MeGal-beta-1,3(Fuc-alpha-1,4)GlcNAc

661433

-

2.4.1.65

GDP-fucose + 2-O-MeGal-beta-1,4GlcNAc = GDP + 2-O-MeGal-beta-1,4(Fuc-alpha-1,3)GlcNAc

661433

-

2.4.1.65

GDP-fucose + Fetuin triantennary asialo agalacto glycoprotein = GDP + ?

661433

-

2.4.1.65

GDP-fucose + Fetuin triantennary asialo glycoprotein = GDP + ?

661433

-

2.4.1.65

GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-O-C6H5 = GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-O-C6H5

661845

-

2.4.1.65

GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin = GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin

661839

-

2.4.1.65

GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-O-C6H5 = GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,3)GlcNAc-O-C6H5

661845

-

2.4.1.65

GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin = GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin

661839

-

2.4.1.65

GDP-fucose + Gal-beta-1,3-GlcNAc-O-(CH2)8CO2CH3 = GDP + Gal-beta-1,3[alpha-fucosyl(1,4)]-GLCNAc-O-(CH2)8CO2CH3

662137

-

2.4.1.65

GDP-fucose + Gal-beta-1,3GlcNAc = GDP + Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc

661277

-

2.4.1.65

GDP-fucose + Gal-beta-1,3GlcNAc-beta-1,3Gal-beta-1,4Glc = GDP + Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-beta-1,3Gal-beta-1,4Glc

661277

-

2.4.1.65

GDP-fucose + Gal-beta-1,3GlcNAc-beta-O-(CH2)7CH3 = GDP + Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-beta-O-(CH2)7CH3

661845

-

2.4.1.65

GDP-Fucose + Gal-beta-1,3GlcNAc-O(CH2)3NHCO(CH2)5NH-biotin = GDP + Gal-beta-1,3[alpha-L-fucosyl-(1,4)]GlcNAcO(CH2)3NHCO(CH2)5NH-biotin

661236

-

2.4.1.65

GDP-fucose + Gal-beta-1,3GlcNAc-O-(CH2)3NHCO(CH2)5NH-biotin = GDP + Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-O-(CH2)3NHCO(CH2)5NH-biotin

662484

-

2.4.1.65

GDP-fucose + Gal-beta-1,3GlcNAcO(CH2)3NHCO(CH2)5NH-biotin = GDP + Gal-beta-1,3[alpha-L-fucosyl-(1,4)]GlcNAcO(CH2)3NHCO(CH2)5NH-biotin

661313

-

2.4.1.65

GDP-fucose + Gal-beta-1,4-Glc = GDP + Gal-beta-1,4(Fuc-alpha-1,3)Glc

661277

-

2.4.1.65

GDP-fucose + Gal-beta-1,4-GlcNAc-O-(CH2)8CO2CH3 = GDP + Gal-beta-1,4[alpha-fucosyl(1,3)]-GLCNAc-O-(CH2)8CO2CH3

662137

-

2.4.1.65

GDP-fucose + Gal-beta-1,4GlcNAc = GDP + Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc + Gal-beta-1,4(Fuc-alpha-1,2)GlcNAc

661277

-

2.4.1.65

GDP-fucose + Gal-beta-1,4GlcNAc-beta-1-R = GDP + Gal-beta-1,4(fuc-alpha-1,3)GlcNAc-beta-1-R

661341

-

2.4.1.65

GDP-fucose + Gal-beta-1,4GlcNAc-beta-O-(CH2)7CH3 = GDP + Gal-beta-1,3(Fuc-alpha-1,3)GlcNAc-beta-O-(CH2)7CH3

661845

-

2.4.1.65

GDP-fucose + GalNAc-beta-1,4GlcNAc-beta-O-Bn = GDP + GalNAc-beta-1,4(Fuc-alpha-1,3)GlcNAc-beta-O-Bn

661433

-

2.4.1.65

GDP-fucose + GlcNAc-beta-1,4GlcNAc-beta-1,4GlcNAc = ?

661433

-

2.4.1.65

GDP-fucose + GlcNAc-beta-1,4GlcNAc-beta-1,4GlcNAc = GDP + ?

661433

-

2.4.1.65

GDP-fucose + GlcNAc-beta-1,4GlcNAc-beta-1,4GlcNAc-beta-1,4GlcNAc = ?

661433

-

2.4.1.65

GDP-fucose + GlcNAc-beta-1,4GlcNAc-beta-1,4GlcNAc-beta-1,4GlcNAc = GDP + ?

661433

-

2.4.1.65

GDP-fucose + GlcNAc-beta-1,4GlcNAc-beta-O-Bn = GDP + GlcNAc-beta-1,4(Fuc-alpha-1,3)GlcNAc-beta-O-Bn

661433

-

2.4.1.65

GDP-fucose + LacNAc = ?

661803

-

2.4.1.65

pyridylamine-lacto-N-neotetraose + GDP-fucose = GDP + ?

661803

-

2.4.1.69

GDP-fucose + asialofetuin = GDP + asialofetuin

657849

-

2.4.1.69

GDP-fucose + Galbeta-O-Bn = GDP + L-Fucalpha(1-2)Galbeta-O-Bn

680997

-

2.4.1.69

GDP-fucose + Galbeta1-4Glc = Fucalpha1-2Galbeta1-4Glc + GDP

677551

-

2.4.1.69

GDP-fucose + Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc = Fucalpha1-2Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc + GDP

677551

-

2.4.1.152

38 entries

2.4.1.214

37 entries

2.4.1.221

4 entries

2.4.1.65

29 entries

2.4.1.69

4 entries

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.271

competitive with respect to NADPH and GDP-4-keto-6-deoxymannose

389515

-

2.4.1.152

-

349725

-

2.4.1.152

competitive inhibition

690403

-

2.4.1.152

2 entries

4.2.1.47

competitive inhibition

653945

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.1.221

2.4

-

pH and temperature not specified in the publication

722118

K_M Value (42 results)

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Show KM Value (42 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.1.152

0.0016

-

pH 6.5, 37°C

639523

2.4.1.152

0.0065

-

pH 7.2, 37°C

639533

2.4.1.152

0.025

-

LacNAcbeta-O-(CH2)5CO2CH3 as substrate

349725

2.4.1.152

0.043

-

-

349722, 349723

2.4.1.152

0.06

-

LacNAc as substrate

349725

2.4.1.214

0.065

-

-

349718

2.4.1.214

0.0683

-

deletion mutant FTdelta23 with 23 residues deleted from the C-terminus

672191

2.4.1.214

0.07864

-

deletion mutant FTdelta66 with 66 residues deleted from the C-terminus

672191

2.4.1.214

0.07967

-

deletion mutant FTdelta38 with 38 residues deleted from the C-terminus

672191

2.4.1.214

0.08016

-

FucT 45, N240A mutant

687684

2.4.1.214

0.08831

-

deletion mutant FTdelta45 with 45 residues deleted from the C-terminus

672191

2.4.1.214

0.08831

-

FucT 45

687684

2.4.1.214

0.09356

-

deletion mutant FTdelta28 with 28 residues deleted from the C-terminus

672191

2.4.1.214

0.09864

-

deletion mutant FTdelta80 with 80 residues deleted from the C-terminus

672191

2.4.1.214

0.11

-

-

349717

2.4.1.214

0.157

-

FucT 45, Y246F mutant

687684

2.4.1.214

0.2223

-

FucT 115

687684

2.4.1.214

0.228

-

deletion mutant FTdelta115 with 115 residues deleted from the C-terminus

672191

2.4.1.214

0.59

1

FucT 45, R195K mutant

687684

2.4.1.214

0.8

-

FucT 45, Y246A mutant

687684

2.4.1.152

5 entries

2.4.1.214

15 entries

2.4.1.221

0.0098

-

pH and temperature not specified in the publication

722118

2.4.1.65

0.03

-

mutant W124R, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin

661839

2.4.1.65

0.034

-

mutant W111Y, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin

661839

2.4.1.65

0.035

-

mutant W124Y, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin

661839

2.4.1.65

0.035

-

wildtype, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin

661839

2.4.1.65

0.0357

-

with Gal-beta-1,3-GlcNAc-O-(CH2)8CO2CH3, strain UA948

662137

2.4.1.65

0.037

-

mutant W111F, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin

661839

2.4.1.65

0.038

-

wildtype, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin

661839

2.4.1.65

0.046

-

mutant W111A, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin

661839

2.4.1.65

0.048

-

with Gal-beta-1,4beta-GlcNAc-O-(CH2)8CO2CH3, wild type, strain NCTC116639

662137

2.4.1.65

0.0481

-

with Gal-beta-1,4-GlcNAc-O-(CH2)8CO2CH3, chimeric FucT UA948(345DNPFIFC)

662137

2.4.1.65

0.0504

-

-

661341

2.4.1.65

0.0546

-

with Gal-beta-1,3-GlcNAc-O-(CH2)8CO2CH3, chimeric FucT 11639(347CNDAHYSALH)

662137

2.4.1.65

0.0683

-

with Gal-beta-1,4-GlcNAc-O-(CH2)8CO2CH3, strain UA948

662137

2.4.1.65

0.153

-

with beta-Gal1,4-GlcNAc-O-(CH2)8CO2CH3, chimeric FucT 11639(1-359)UA948(361-462)

662137

2.4.1.65

0.188

-

with Gal-beta-1,3-GlcNAc-O-(CH2)8CO2CH3, chimeric FucT UA948(1-360)11639(360-478)

662137

2.4.1.65

0.213

-

with Gal-beta-1,3-GlcNAc-O-(CH2)8CO2CH3, chimeric FucT UA948(345DNPFIFC)

662137

2.4.1.65

0.236

-

with Gal-beta-1,4-GlcNAc-O-(CH2)8CO2CH3, chimeric FucT UA948(1-360)11639(360-478)

662137

2.4.1.65

0.244

-

with Gal-beta-1,4-GlcNAc-O-(CH2)8CO2CH3, chimeric FucT 11639(347CNDAHYSALH)

662137

2.4.1.69

0.05

-

pH 6.0, 37°C. wild-type enzyme

657849

2.4.1.69

0.0909

-

pH 6.0, 37°Cmutant enzyme F280SS

657849

2.4.1.69

0.178

-

pH 6.0, 37°C, mutant enzyme G247S

657849

2.4.1.65

18 entries

2.4.1.69

3 entries

K_i Value (4 results)

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Show KI Value (4 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.1.1.271

0.055

-

-

389515

2.4.1.152

0.0062

-

LacNAc as substrate

349725

2.4.1.152

0.031

-

LacNAcbeta-O-(CH2)5CO2CH3 as substrate

349725

2.4.1.152

2 entries

4.2.1.47

0.0789

-

pH 7, 37°C

653945

References & Links

Literature References (44)

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Show Reference (44 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

349715

11420147

Cloning and expression of alpha1,3-fucosyltransferase homologues from Arabidopsis thaliana

2001

Wilson, I.B.H.; Rendic, D.; Freilinger, A.; Dumic, J.; Altmann, F.; Mucha, J.; Müller, S.; Hauser, M.T.

Biochim. Biophys. Acta

1527

88-96

349716

11382750

Identification of core alpha1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseradish peroxidase epitope

2001

Fabini, G.; Freilinger, A.; Altmann, F.; Wilson, I.B.H.

J. Biol. Chem.

276

28058-28067

349717

10419500

Purification, cDNA cloning, and expression of GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase from mung beans

1999

Leiter, H.; Mucha, J.; Staudacher, E.; Grimm, R.; Glossl, J.; Altmann, F.

J. Biol. Chem.

274

21830-21839

349718

10567717

Characterization of core alpha1-3-fucosyltransferase from the snail Lymnaea stagnalis that is involved in the synthesis of complex type N-glycans

1999

Van Tetering, A.; Schiphorst, W.E.C.M.; van den Eijnden, D.H.; van Die, I.

FEBS Lett.

461

311-314

349719

1868856

GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1-6GlcNAc)-Asn-peptide) alpha1-3-fucosyltransferase activity in honeybee (Apis mellifica) venom glands. The difucosylation of asparagine-bound N-acetylglucosamine

1991

Staudacher, E.; Altmann, F.; Glossl, J.; M"rz, L.; Schachter, H.; Kamerling, J.P.; HÃ¥rd, K.; Vliegenthart, J.F.G.

Eur. J. Biochem.

199

745-751

349721

6540777

The Chinese hamster ovary glycosylation mutants LEC11 and LEC12 express two novel GDP-fucose:N-acetylglucosaminide 3-alpha-L-fucosyltransferase enzymes

1984

Campbell, C.; Stanley, P.

J. Biol. Chem.

259

11208-11214

349722

1995616

Purification and characterization of GDP-L-Fuc-N-acetyl-beta-D-glucosaminide alpha1,3 fucosyltransferase from human neuroblastoma cells. Unusual substrate specificities of the tumor enzyme

1991

Foster, C.S.; Gillies, D.R.B.; Glick, M.C.

J. Biol. Chem.

266

3526-3531

349723

1733970

Purification of the beta-N-acetylglucosaminide alpha 1,3-fucosyltransferase from human serum

1992

Sarnesto, A.; Kohlin, T.; Hindsgaul, O.; Vogele, K.; Blaszczyk-Thurin, M.; Thurin, J.

J. Biol. Chem.

267

2745-2752

349724

8748155

Functional purification and characterization of a GDP-fucose: beta-N-acetylglucosamine (Fuc to Asn linked GlcNAc) alpha1,3-fucosyltransferase from mung beans

1995

Staudacher, E.; Dalik, T.; Wawra, P.; Altmann, F.; Maerz, L.

Glycoconj. J.

12

780-786

349725

8780523

Mechanism and specificity of human alpha-1,3-fucosyltransferase V

1996

Murray, B.W.; Takayama, S.; Schultz, J.; Wong, C.H.

Biochemistry

35

11183-11195

349726

8617325

Schistosoma mansoni: characterization of an alpha 1-3 fucosyltransferase in adult parasites

1996

DeBose-Boyd, R.A.; Nyame, A.K.; Cummings, R.D.

Exp. Parasitol.

82

1-10

349727

9675224

Molecular cloning and characterization of an alpha1,3 fucosyltransferase, CEFT-1, from Caenorhabditis elegans

1998

DeBose-Boyd, R.A.; Nyame, A.K.; Cummings, R.D.

Glycobiology

8

905-917

389515

10480878

Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli

1999

Menon, S.; Stahl, M.; Kumar, R.; Xu, G.Y.; Sullivan, F.

J. Biol. Chem.

274

26743-26750

639523

9448836

Measurement of alpha(1-3)fucosyltransferase activity using scintillation proximity

1998

Hood, C.M.; Kelly, V.A.; Bird, M.I.; Britten, C.J.

Anal. Biochem.

255

8-12

639533

8323955

Oligosaccharide specificity of normal human hepatocyte alpha1-3 fucosyltransferase

1993

Jezequel-Cuer, M.; N'Guyen-Cong, H.; Biou, D.; Durand, G.

Biochim. Biophys. Acta

1157

252-258

653945

10673432

Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose

2000

Somoza, J.R.; Menon, S.; Schmidt, H.; Joseph-McCarthy, D.; Dessen, A.; Stahl, M.L.; Somers, W.S.; Sullivan, F.X.

Structure Fold. Des.

8

123-135

657849

15250822

Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G-->A and 839T-->C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal

2004

Serpa, J.; Mendes, N.; Reis, C.A.; Santos Silva, L.F.; Almeida, R.; Le Pendu, J.; David, L.

Biochem. J.

383

469-474

658279

15081009

Glycosyltransferase activity can be selectively modulated by chemical modifications of acceptor substrates

2004

Galan, M.C.; Dodson, C.S.; Venot, A.P.; Boons, G.J.

Bioorg. Med. Chem. Lett.

14

2205-2208

659454

15653684

Novel poly-GalNAcbeta1-4GlcNAc (LacdiNAc) and fucosylated poly-LacdiNAc N-glycans from mammalian cells expressing beta1,4-N-acetylgalactosaminyltransferase and alpha1,3-fucosyltransferase

2005

Kawar, Z.S.; Haslam, S.M.; Morris, H.R.; Dell, A.; Cummings, R.D.

J. Biol. Chem.

280

12810-12819

661236

15535972

Deletion of the cytoplasmic domain of human alpha3/4 fucosyltransferase III causes the shift of the enzyme to early Golgi compartments

2004

Sousa, V.L.; Brito, C.; Costa, J.

Biochim. Biophys. Acta

1675

95-104

661277

12770774

alpha1,3 Fucosyltransferases in cystic fibrosis airway epithelial cells

2003

Stoykova, L.I.; Liu, A.; Scanlin, T.F.; Glick, M.C.

Biochimie

85

363-367

661313

14977360

Effect of the manganese ion on human alpha3/4 fucosyltransferase III activity

2004

Palma, A.S.; Morais, V.A.; Coelho, A.V.; Costa, J.

BioMetals

17

35-43

661341

14741245

Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism

2004

Norris, A.J.; Whitelegge, J.P.; Strouse, M.J.; Faull, K.F.; Toyokuni, T.

Bioorg. Med. Chem. Lett.

14

571-573

661433

12681913

The binding characteristics and utilization of Aleuria aurantia, Lens culinaris and few other lectins in the elucidation of fucosyltransferase activities resembling cloned FT VI and apparently unique to colon cancer cells

2003

Chandrasekaran, E.V.; Chawda, R.; Rhodes, J.M.; Locke, R.D.; Piskorz, C.F.; Matta, K.L.

Carbohydr. Res.

338

887-901

661803

14734022

Yeast cells harboring human alpha-1,3-fucosyltransferase at the cell surface engineered using Pir, a cell wall-anchored protein

2004

Abe, H.; Ohba, M.; Shimma, Y.I.; Jigami, Y.

FEMS Yeast Res.

4

417-425

661839

14718375

Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain

2004

Dupuy, F.; Germot, A.; Julien, R.; Maftah, A.

Glycobiology

14

347-356

661845

15864437

Biochemical characterization of Silene alba alpha4-fucosyltransferase and Lewis a products

2005

Leonard, R.; Lhernould, S.; Carlue, M.; Fleurat, P.; Maftah, A.; Costa, G.

Glycoconj. J.

22

71-78

662137

12676935

C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer

2003

Ma, B.; Wang, G.; Palcic, M.M.; Hazes, B.; Taylor, D.E.

J. Biol. Chem.

278

21893-21900

662484

14636711

Stable expression of recombinant human alpha3/4 fucosyltransferase III in Spodoptera frugiperda Sf9 cells

2003

Morais, V.A.; Costa, J.

J. Biotechnol.

106

69-75

671893

17029591

Towards abolition of immunogenic structures in insect cells: characterization of a honey-bee (Apis mellifera) multi-gene family reveals both an allergy-related core alpha1,3-fucosyltransferase and the first insect Lewis-histo-blood-group-related antigen-synthesizing enzyme

2007

Rendic, D.; Klaudiny, J.; Stemmer, U.; Schmidt, J.; Paschinger, K.; Wilson, I.B.

Biochem. J.

402

603

672191

16800635

Carboxyl terminus of Helicobacter pylori alpha1,3-fucosyltransferase determines the structure and stability

2006

Lin, S.W.; Yuan, T.M.; Li, J.R.; Lin, C.H.

Biochemistry

45

8108-8116

673753

15691739

Co-expression of two mammalian glycosyltransferases in the yeast cell wall allows synthesis of sLex

2005

Salo, H.; Sievi, E.; Suntio, T.; Mecklin, M.; Mattila, P.; Renkonen, R.; Makarow, M.

FEMS Yeast Res.

5

341-350

677551

16477664

Large-scale synthesis of H-antigen oligosaccharides by expressing Helicobacter pylori alpha1,2-fucosyltransferase in metabolically engineered Escherichia coli cells

2006

Drouillard, S.; Driguez, H.; Samain, E.

Angew. Chem.

45

1778-1780

680997

17492468

Potential tumor markers for human gastric cancer: an elevation of glycan:sulfotransferases and a concomitant loss of alpha1,2-fucosyltransferase activities

2007

Chandrasekaran, E.V.; Xue, J.; Piskorz, C.; Locke, R.D.; Toth, K.; Slocum, H.K.; Matta, K.L.

J. Cancer Res. Clin. Oncol.

133

599-611

685736

17636386

Stable expression of an active soluble recombinant form of human fucosyltransferase IX in Spodoptera frugiperda Sf9 cells

2007

Brito, C.; Gouveia, R.; Costa, J.

Biotechnol. Lett.

29

1623-1630

686972

17369288

Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family

2007

Nguyen, K.; van Die, I.; Grundahl, K.M.; Kawar, Z.S.; Cummings, R.D.

Glycobiology

17

586-599

687115

17556010

Overexpression of fucosyltransferase IV in A431 cell line increases cell proliferation

2007

Yang, X.; Zhang, Z.; Jia, S.; Liu, Y.; Wang, X.; Yan, Q.

Int. J. Biochem. Cell Biol.

39

1722-1730

687445

17875554

Free oligosaccharides with Lewis x structure expressed in the segmentation period of zebrafish embryo

2007

Moriguchi, K.; Takemoto, T.; Aoki, T.; Nakakita, S.; Natsuka, S.; Hase, S.

J. Biochem.

142

213-227

687684

17251184

Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and inhibitor design

2007

Sun, H.Y.; Lin, S.W.; Ko, T.P.; Pan, J.F.; Liu, C.L.; Lin, C.N.; Wang, A.H.; Lin, C.H.

J. Biol. Chem.

282

9973-9982

690403

17923099

A miniaturized high-throughput screening assay for fucosyltransferase VII

2008

Ahsen, O.; Voigtmann, U.; Klotz, M.; Nifantiev, N.; Schottelius, A.; Ernst, A.; Mueller-Tiemann, B.; Parczyk, K.

Anal. Biochem.

372

96-105

722118

22588082

Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation

2012

Chen, C.I.; Keusch, J.J.; Klein, D.; Hess, D.; Hofsteenge, J.; Gut, H.

EMBO J.

31

3183-3197

722369

23045360

6-Alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2

2013

Al-Shareffi, E.; Chaubard, J.L.; Leonhard-Melief, C.; Wang, S.K.; Wong, C.H.; Haltiwanger, R.S.

Glycobiology

23

188-198

757939

28910607

Molecular cloning and functional expression of Lewis type alpha1,3/alpha1,4-fucosyltransferase cDNAs from Mangifera indica L.

2017

Okada, T.; Ihara, H.; Ito, R.; Ikeda, Y.

Phytochemistry

144

98-105

757946

31252202

Characterization of MiFUT11 from Mangifera indica L. A functional core alpha1,3-fucosyltransferase potentially involved in the biosynthesis of immunogenic carbohydrates in mango fruit

2019

Okada, T.; Ihara, H.; Ikeda, Y.

Phytochemistry

165

112050

Links to other databases for GDP-fucose

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Show Links (1 entry)

ChEBI

PubChem

-