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Ligand alkyldihydroxyacetone phosphate

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.101

alkyldihydroxyacetone phosphate + NADPH + H+ = 1-alkyl-sn-glycerol 3-phosphate + NADP+

285689, 285691, 285696, 285690, 285684, 285688, 285685

-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.26

1-acylglycerone 3-phosphate + long-chain alcohol = alkylglycerone 3-phosphate + long-chain acid anion + H+

-

-

2.5.1.26

1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion

-

-

2.5.1.26

2 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.101

alkyldihydroxyacetone phosphate + NADPH + H+ = 1-alkyl-sn-glycerol 3-phosphate + NADP+

285684, 285690, 285692, 285688, 285696, 285689, 285685, 285686, 285691, 285687

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Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.5.1.26

1-acylglycerone 3-phosphate + long-chain alcohol = alkylglycerone 3-phosphate + long-chain acid anion + H+

489880, -

-

2.5.1.26

1-acyl-glycerone 3-phosphate + a long-chain alcohol = an alkyl-glycerone 3-phosphate + a long-chain acid anion

-

-

2.5.1.26

2 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.101

at high concentrations

285688

-

Enzyme Kinetic Parameters

References & Links

Literature References (11)

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Show Reference (11 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

285684

4403490

Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides

1972

LaBelle, E.F.; Hajra, A.K.

J. Biol. Chem.

247

5825-5834

285685

500614

Subcellular localization of acyl coenzyme A: dihydroxyacetone phosphate acyltransferase in rat liver peroxisomes (microbodies)

1979

Hajra, A.K.; Burke, C.L.; Jones, C.L.

J. Biol. Chem.

254

10896-10900

285686

6271231

Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles

1981

Ballas, L.M.; Bell, R.M.

Biochim. Biophys. Acta

665

586-595

285687

6562019

Localization of the initial steps in alkoxyphospholipid biosynthesis in glycosomes (microbodies) of Trypanosoma brucei

1984

Opperdoes, F.R.

FEBS Lett.

169

35-39

285688

3954368

Subcellular distribution and properties of acyl/alkyl dihydroxyacetone phosphate reductase in rodent livers

1986

Ghosh, M.K.; Hajra, A.K.

Arch. Biochem. Biophys.

245

523-530

285689

3646870

Properties of the enzymes catalyzing the biosynthesis of lysophosphatidate and its ether analog in cultured fibroblasts from Zellweger syndrome patients and normal controls

1987

Webber, K.O.; Datta, N.S.; Hajra, A.K.

Arch. Biochem. Biophys.

254

611-620

285690

2335525

Purification and properties of acyl/alkyl dihydroxyacetone-phosphate reductase from guinea pig liver peroxisomes

1990

Datta, S.C.; Ghosh, M.K.; Hajra, A.K.

J. Biol. Chem.

265

8268-8274

285691

-

The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae

1992

Racenis, P.V.; Lai, J.L.; Das, A.K.; Mullick, P.C.; Hajra, A.K.; Greenberg, M.L.

J. Bacteriol.

174

5704-5710

285692

1495422

Acyl/alkyldihydroxyacetone phosphate reductase from guinea pig liver peroxisomes

1992

Hajra, A.K.; Datta, S.C.; Ghosh, M.K.

Methods Enzymol.

209

402-407

285696

10734090

Induction of the peroxisomal glycerolipid-synthesizing enzymes during differentiation of 3T3-L1 adipocytes. Role in triacylglycerol synthesis

2000

Hajra, A.K.; Larkins, L.K.; Das, A.K.; Hemati, N.; Erickson, R.L.; MacDougald, O.A.

J. Biol. Chem.

275

9441-9446

489880

7096336

Alkyldihydroxyacetone-P synthase. Solubilization, partial purification, new assay method, and evidence for a ping-pong mechanism

1982

Brown, A.J.; Snyder, F.

J. Biol. Chem.

257

8835-8839

Links to other databases for alkyldihydroxyacetone phosphate

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Show Links (1 entry)