Ligand 4-nitrobenzoyl-CoA
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Basic Ligand Information
C28H39N8O19P3S
4-nitrobenzoyl-CoA
MQPUEXKBWYQBOT-TYHXJLICSA-N
Related pathways
MetaCyc
aureothin biosynthesis, spectinabilin biosynthesis
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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4-nitrobenzoyl-CoA + malonyl-CoA + 4 (S)-methylmalonyl-CoA + 4 NADPH + 4 H+ = demethylluteothin + 5 CO2 + 6 CoA + 4 NADP+ + 3 H2O
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4-nitrobenzoyl-CoA + malonyl-CoA + 6 (S)-methylmalonyl-CoA + 6 NADPH + 4 H+ = demethyldeoxyspectinabilin + 7 CO2 + 8 CoA + 6 NADP+ + 5 H2O
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Product in Enzyme-catalyzed Reactions (2 results)
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ATP + 4-nitrobenzoate + CoA = AMP + diphosphate + 4-nitrobenzoyl-CoA
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4-Nitrobenzoate + CoA + ATP = 4-Nitrobenzoyl-CoA + AMP + diphosphate
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Enzyme Kinetic Parameters
References & Links
Literature References (7)
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Characterization of a renal medium chain acyl-CoA synthetase responsible for glycine conjugation in mouse kidney mitochondria
1999
Kasuya, F.; Igarashi, K.; Fukui, M.
Chem. Biol. Interact.
118
233-246
Functional analysis of the aureothin iterative type I polyketide syntase
2005
He, J.; Hertweck, C.
ChemBioChem
6
908-912
Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways An evolutionary perspective
2007
Traitcheva, N.; Jenke-Kodama, H.; He, J.; Dittmann, E.; Hertweck, C.
ChemBioChem
8
1841-1849
Non-colinear polyketide biosynthesis in the aureothin and neoaureothin pathways An evolutionary perspective
2007
Traitcheva, N.; Jenke-Kodama, H.; He, J.; Dittmann, E.; Hertweck, C.
ChemBioChem
8
1841-1849
Cloning and heterologous expression of the spectinabilin biosynthetic gene cluster from Streptomyces spectabilis
2010
Choi, Y.; Johannes, T.; Simurdiak, M.; Shao, Z.; Lu, H.; Zhao, H.
Mol. Biosyst.
6
336-338
Evolution of metabolic diversity in polyketide-derived pyrones Using the non-colinear aureothin assembly line as a model system
2009
Busch, B.; Hertweck, C.
Phytochemistry
70
1833-1840
Evolution of metabolic diversity in polyketide-derived pyrones Using the non-colinear aureothin assembly line as a model system
2009
Busch, B.; Hertweck, C.
Phytochemistry
70
1833-1840
Links to other databases for 4-nitrobenzoyl-CoA
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