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competitive, coadministration with CD2+ results in inhibition of enzyme and glutaredoxin and enhanced susceptibility to apoptosis
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inhibition of the enzyme by oxalomalate reduces glutamate secretion and eliminates the effect of iron ions on the latter
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significantly increases citrate content and reduces the enzyme's activity, while slightly inducing its protein level. Specific activities of amino acid-metabolizing enzymes are induced in oxalomalate-treated callus cells, overview
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inhibition of aconitase activity, leading to inhibition of L-glutamate production, L-cystine uptake, and decrease in glutathione concentration in lens epithelial cells and retinal pigment epithelial cells
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Glutamate biosynthesis in an organism lacking a Krebs tricarboxylic acid cycle. V. Isolation of alpha-hydroxy-gamma-ketoglutarate (HGK) in Acetobacter suboxydans
1966
Sekizawa, Y.; Maragoudakis, M.E.; King, T.E.; Cheldelin, V.H.
Biochemistry
5
2392-2398
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Aconitase
1971
Pickworth Glusker, J.
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
413-439
Purification and properties of isocitrate dehydrogenase (NADP) from Thermus aquaticus YT-1, Bacillus subtilis-168 and Chlamydomonas reinhardti-Y-2
1973
Ramaley, R.F.; Hudock, M.O.
Biochim. Biophys. Acta
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NADP-specific isocitrate dehydrogenase of Mycobacterium phlei ATCC 354: purification and characterization
1987
Dhariwal, K.R.; Venkitasubramanian, T.A.
J. Gen. Microbiol.
133
2457-2460
Mitochondrial NADP+-dependent isocitrate dehydrogenase protects cadmium-induced apoptosis
2006
Kil, I.S.; Shin, S.W.; Yeo, H.S.; Lee, Y.S.; Park, J.W.
Mol. Pharmacol.
70
1053-1061
Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase
2008
Lall, M.M.; Ferrell, J.; Nagar, S.; Fleisher, L.N.; McGahan, M.C.
Invest. Ophthalmol. Vis. Sci.
49
310-319
Aconitate hydratase of mammals under oxidative stress
2008
Matasova, L.V.; Popova, T.N.
Biochemistry (Moscow)
73
957-964
Inhibition of aconitase in Citrus fruit callus results in a metabolic shift towards amino acid biosynthesis
2011
Degu, A.; Hatew, B.; Nunes-Nesi, A.; Shlizerman, L.; Zur, N.; Katz, E.; Fernie, A.R.; Blumwald, E.; Sadka, A.
Planta
234
501-513