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Ligand 2'-deoxyadenosine 5'-monophosphate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for 2'-deoxyadenosine 5'-monophosphate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.4.11

ATP + dAMP = ADP + dADP

642684, 209854

-

2.7.4.13

ATP + dAMP = ADP + dADP

739645

-

In Vivo Product in Enzyme-catalyzed Reactions (15 results)

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Show Natural Product (15 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.113

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.113

UTP + 2'-deoxyadenosine = UDP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.113

2 entries

2.7.1.145

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.74

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

2qro, 3D-view

2.7.1.74

NTP + 2'-deoxyadenosine = NDP + 2'-deoxyadenosine 5'-phosphate

0

2qro, 3D-view

2.7.1.74

UTP + 2'-deoxyadenosine = UDP + 2'-deoxyadenosine 5'-phosphate

0

2qro, 3D-view

2.7.1.74

ATP + deoxyadenosine = ADP + dAMP

0

2qro, 3D-view

2.7.1.74

UTP + deoxyadenosine = UDP + dAMP

0

2qro, 3D-view

2.7.1.76

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

ATP + deoxyadenosine = ADP + 5'-dAMP

641937, 641977, 640567, 641984

-

2.7.1.76

ATP + 2'-deoxyadenosine = ADP + dAMP

0

-

2.7.1.76

ATP + deoxyadenosine = ADP + dAMP

0

-

2.7.1.74

5 entries

2.7.1.76

4 entries

3.6.1.15

dADP + H2O = dAMP + phosphate

0

-

6.2.1.1

dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA

652101

-

6.5.1.1

dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n

0

-

Substrate in Enzyme-catalyzed Reactions (37 results)

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Show Substrate (37 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.8.99.2

dAMP + sulfite + cytochrome c = deoxyadenylyl sulfate + ?

393944

-

2.4.2.6

dAMP + 2,6-dichloropurine = adenine + 2,6-dichloropurin-9-yl-2'-deoxy-beta-D-ribose 5'-phosphate

638050

-

2.4.2.6

dAMP + base = dNMP + adenine

674900

-

2.4.2.6

2 entries

2.7.1.77

5'-dAMP + thymidine = 5'-deoxyadenosine + TMP

641993

-

2.7.4.1

dAMP + (phosphate)n+1 = dADP + (phosphate)n

760249

-

2.7.4.10

dGTP + dAMP = dGDP + dADP

642538

-

2.7.4.11

ATP + dAMP = ADP + dADP

642684, 209854

-

2.7.4.13

ATP + dAMP = ADP + dADP

661371, 209854, 663294, 739645, 642542, 642544

-

2.7.4.14

ATP + dAMP = ADP + dADP

645156

-

2.7.4.18

2'-deoxy-adenosine 5'-phosphate + trans-farnesyl diphosphate = 2'-deoxyadenosine + trans-farnesyl triphosphate

645171

-

2.7.4.3

ATP + dAMP = ADP + dADP

642598, 642609, 642585, 642592, 642567, 642603, 642574, 642580, 642572, 703721, 704047

-

2.7.4.3

dATP + dAMP = dADP

642598

-

2.7.4.3

dATP + dAMP = dADP + dADP

673656

-

2.7.4.33

2'-dAMP + (phosphate)n = 2'-dADP + (phosphate)n-1

718620

-

2.7.4.33

2'-deoxy-AMP + [phosphate]n = 2'-deoxy-ADP + [phosphate]n-1

718620

-

2.7.4.33

dAMP + (phosphate)n+1 = dADP + (phosphate)n

758213

-

2.7.4.33

dAMP + [phosphate]n = dADP + [phosphate]n-1

722513

-

2.7.4.3

3 entries

2.7.4.33

4 entries

2.7.4.4

ATP + dAMP = ADP + dADP

722061

-

2.7.4.8

GTP + dAMP = GDP + dADP

739240

-

2.7.4.9

ATP + dAMP = ADP + dADP

695005

-

2.7.9.1

2'-dAMP + phosphoenolpyruvate + diphosphate = 2'-dATP + pyruvate + phosphate

645463

-

3.1.3.1

2'-deoxyadenosine 5'-monophosphate + H2O = ?

681341

-

3.1.3.1

5'-dAMP + H2O = ?

94596

-

3.1.3.1

dAMP + H2O = ?

94572

-

3.1.3.2

5'-dAMP + H2O = deoxyadenosine + phosphate

134760, 664223

-

3.1.3.2

dAMP + H2O = 2'-deoxyadenosine + phosphate

682408

-

3.1.3.2

dAMP + H2O = deoxyadenosine + phosphate

134765, 716486

-

3.1.3.1

3 entries

3.1.3.2

3 entries

3.1.3.25

5'-dAMP + H2O = adenosine + phosphate

114220

-

3.1.3.5

5'-dAMP + H2O = deoxyadenosine + phosphate

656266, 729593, 751052, 751960, 95037, 95074, 95035, 95042, 95045, 95054, 95058, 95051, 95021, 95065, 95028, 95033, 95067, 663466

2pau, 3D-view

3.1.3.5

dAMP + H2O = deoxyadenosine + phosphate

652095

2pau, 3D-view

3.1.3.5

2 entries

3.1.3.89

5'-dAMP + H2O = deoxyadenosine + phosphate

656266, 722956, 749824

-

3.1.4.17

5'-dAMP + H2O = ?

692369

-

3.5.4.17

dAMP + H2O = dIMP + NH3

246706

-

3.5.4.18

dAMP + H2O = dIMP + NH3

172176, 246716, 246717

-

3.5.4.4

2'-dAMP + H2O = 2'-dIMP + NH3

209613

-

3.5.4.6

5-deoxyadenylic acid + H2O = dIMP + NH3

209680, 209672

-

3.5.4.7

deoxyadenosine monophosphate + H2O = deoxyinosine monophosphate + NH3

209715

-

Product in Enzyme-catalyzed Reactions (110 results)

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Show Product (110 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.33

1-methyl-dAMP + 2-oxoglutarate + O2 = dAMP + formaldehyde + succinate + CO2

0

-

2.7.1.113

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.113

GTP + 2'-deoxyadenosine = GDP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.113

UTP + 2'-deoxyadenosine = UDP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.113

ATP + deoxyadenosine = ADP + dAMP

0, 640555, 640553, 640558

-

2.7.1.145

2'-deoxy-2'-fluoroadenosine 3'-triphosphate + 2'-deoxyadenosine = 2'-deoxy-2'-fluoroadenosine 3'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.145

2'-deoxyadenosine + ATP = 2'-deoxyadenosine 5'-phosphate + ADP

0

-

2.7.1.145

adenosine-2'-deoxy-3'-triphosphate + 2'-deoxyadenosine = adenosine-2'-deoxy-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.145

adenosine-3'-deoxy-2'-triphosphate + 2'-deoxyadenosine = adenosine-3'-deoxy-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.145

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.113

4 entries

2.7.1.145

5 entries

2.7.1.146

ADP + 2'-deoxyadenosine = AMP + dAMP

0

-

2.7.1.20

ATP + 2'-deoxy-adenosine = ADP + 2'-deoxy-AMP

0

-

2.7.1.20

dADP + adenosine = dAMP + AMP

0

-

2.7.1.20

ATP + deoxyadenosine = ADP + deoxyadenosine 5'-phosphate

0

-

2.7.1.20

3 entries

2.7.1.21

ATP + deoxyadenosine = ADP + dAMP

0

-

2.7.1.74

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

2qro, 3D-view

2.7.1.74

NTP + 2'-deoxyadenosine = NDP + 2'-deoxyadenosine 5'-phosphate

0

2qro, 3D-view

2.7.1.74

UTP + 2'-deoxyadenosine = UDP + 2'-deoxyadenosine 5'-phosphate

0

2qro, 3D-view

2.7.1.74

ATP + deoxyadenosine = ADP + dAMP

0

2qro, 3D-view

2.7.1.74

NTP + deoxyadenosine = NDP + dAMP

0

2qro, 3D-view

2.7.1.74

UTP + deoxyadenosine = UDP + dAMP

0

2qro, 3D-view

2.7.1.76

2'-deoxyadenosine-3'-fluoro-3'-triphosphate + 2'-deoxyadenosine = 2'-deoxyadenosine-3'-fluoro-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

2'-deoxyadenosine-3'-fluoroara-3'-triphosphate + 2'-deoxyadenosine = 2'-deoxyadenosine-3'-fluoroara-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

2'-deoxyadenosine-3'-triphosphate + 2'-deoxyadenosine = 2'-deoxyadenosine-3'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

3'-deoxyadenosine 2'-triphosphate + 2'-deoxyadenosine = 3'-deoxyadenosine-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

3'-deoxyadenosine-3'-fluoro-2'-triphosphate + 2'-deoxyadenosine = 3'-deoxyadenosine-3'-fluoro-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

3'-deoxyadenosine-3'-fluoroxylo-2'-triphosphate + 2'-deoxyadenosine = 3'-deoxyadenosine-3'-fluoroxylo-2'-diphosphate + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

CTP + 2'-deoxyadenosine = CDP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

GTP + 2'-deoxyadenosine = GDP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

UTP + 2'-deoxyadenosine = UDP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.76

ATP + deoxyadenosine = ADP + 5'-dAMP

641937, 641977, 640567, 641984

-

2.7.1.76

ATP + 2'-deoxyadenosine = ADP + dAMP

0

-

2.7.1.76

ATP + deoxyadenosine = ADP + dAMP

641984, 641937, 641089, 641977, 641981, 0, 641988, 641980, 640567, 641974, 641976, 641950, 641987, 640566

-

2.7.1.76

CTP + deoxyadenosine = CDP + dAMP

641988, 0

-

2.7.1.76

dATP + deoxyadenosine = dADP + dAMP

0

-

2.7.1.76

dCTP + deoxyadenosine = dCDP + dAMP

0

-

2.7.1.76

dTTP + deoxyadenosine = dTDP + dAMP

641981, 0

-

2.7.1.76

GTP + deoxyadenosine = GDP + dAMP

641981, 641988

-

2.7.1.76

TTP + deoxyadenosine = TDP + dAMP

641988, 0

-

2.7.1.76

UTP + deoxyadenosine = UDP + dAMP

641988, 0, 641981

-

2.7.1.77

4-nitrophenyl phosphate + 2'-deoxyadenosine = 2'-deoxyadenosine 5'-phosphate + 2'-deoxyadenosine 3'-phosphate + 4-nitrophenol

0, 641993

-

2.7.1.77

4-nitrophenyl phosphate + 2'-deoxyadenosine = 4-nitrophenol + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.1.77

phenyl phosphate + deoxyadenosine = dAMP + phenol

0

-

2.7.1.74

6 entries

2.7.1.76

20 entries

2.7.1.77

3 entries

2.7.1.B20

ATP + 2'-deoxyadenosine = ADP + 2'-deoxyadenosine 5'-phosphate

0

-

2.7.6.1

dATP + D-ribose 5-phosphate = dAMP + 5-phospho-alpha-D-ribose 1-diphosphate

642710, 642712, 642729, 0, 642738, 642716

-

2.7.6.3

dATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = dAMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine

0

-

2.7.6.4

dATP + ADP = dAMP + adenosine 3'-diphosphate 5'-diphosphate

0, 645216

-

2.7.6.4

dATP + AMP = dAMP + adenosine 3'-diphosphate 5'-phosphate

0

-

2.7.6.4

dATP + ApG = dAMP + ApGpp

0

-

2.7.6.4

dATP + ApUpG = dAMP + ApUpGpp

0

-

2.7.6.4

dATP + ATP = dAMP + adenosine 3'-diphosphate 5'-triphosphate

0

-

2.7.6.4

dATP + beta-NADH = dAMP + ?

0

-

2.7.6.4

dATP + CTP = dAMP + cytidine 3'-diphosphate 5'-triphosphate

0

-

2.7.6.4

dATP + GDP = dAMP + guanosine 3'-diphosphate 5'-diphosphate

0, 645216

-

2.7.6.4

dATP + GDP-glucose = dAMP + ?

0

-

2.7.6.4

dATP + GMP = dAMP + guanosine 3'-diphosphate 5'-phosphate

0

-

2.7.6.4

dATP + GpA = dAMP + GpApp

0

-

2.7.6.4

dATP + GpG = dAMP + GpGpp

0

-

2.7.6.4

dATP + GTP = dAMP + guanosine 3'-diphosphate 5'-triphosphate

0

-

2.7.6.4

dATP + IDP = dAMP + inosine 3'-diphosphate 5'-triphosphate

0

-

2.7.6.4

dATP + IMP = dAMP + inosine 3'-diphosphate 5'-phosphate

0

-

2.7.6.4

dATP + ITP = dAMP + inosine 3'-diphosphate 5'-triphosphate

0

-

2.7.6.4

dATP + UDP-glucose = dAMP + ?

0

-

2.7.6.4

dATP + UpG = dAMP + UpGpp

0

-

2.7.6.4

dATP + UTP = dAMP + uridine 3'-diphosphate 5'-triphosphate

0

-

2.7.6.4

19 entries

2.7.6.5

dATP + GTP = dAMP + guanosine 3'-diphosphate 5'-triphosphate

0

-

2.7.7.79

p-tRNAHis + dATP + GTP = pppGp-tRNAHis + dAMP + diphosphate

0

-

3.1.13.4

poly(a)-ssDNA + H2O = 5'-dAMP

650987

-

3.1.3.7

2'-deoxyadenosine 3',5'-bisphosphate + H2O = 2'-deoxyadenosine 5'-phosphate + phosphate

0

-

3.1.3.97

2'-deoxy-adenosine 3',5'-bisphosphate + H2O = 2'-deoxy-adenosine 5'-phosphate + phosphate

0

-

3.1.30.1

duplex deoxyadenosine-deoxythymine homopolymer + H2O = 5'-dAMP + 5'-TMP + 5'-phosphooligonucleotides

134994

4cxo, 3D-view

3.1.30.1

polydeoxyadenylic acid + H2O = 5'-dAMP + 5'-phosphooligonucleotides

134996, 134994

4cxo, 3D-view

3.1.30.1

2 entries

3.1.4.17

3',5'-cdAMP + H2O = 5'-dAMP

0

-

3.6.1.12

dATP + H2O = dAMP + diphosphate

0

-

3.6.1.15

dADP + H2O = dAMP + phosphate

0

-

3.6.1.17

2'-deoxyadenosine adenosine tetraphosphate + H2O = ATP + 2'-dAMP + 2'-dATP + AMP

209914

-

3.6.1.23

dATP + H2O = dAMP + diphosphate

0

-

3.6.1.5

dATP + 2 H2O = dAMP + 2 phosphate

0

-

3.6.1.5

dATP + H2O = dAMP + phosphate

0

-

3.6.1.5

dATP + H2O = dAMP + phosphate + H+

0

-

3.6.1.5

3 entries

3.6.1.55

dATP + H2O = dAMP + diphosphate

0

-

3.6.1.56

dADP + H2O = dAMP + phosphate

0

-

3.6.1.56

dATP + H2O = dAMP + diphosphate

0

-

3.6.1.56

2 entries

3.6.1.58

dADP + H2O = dAMP + phosphate

0

-

3.6.1.6

dADP + H2O = dAMP + phosphate

0

-

3.6.1.65

dATP + H2O = dAMP + diphosphate

0

-

3.6.1.67

dATP + H2O = dAMP + diphosphate

0

-

3.6.1.8

dATP + H2O = dAMP + diphosphate

210225

-

3.6.1.9

dATP + H2O = dAMP + diphosphate

0

-

4.3.2.2

2'-deoxy-succino-AMP = 2'-deoxy-AMP + fumarate

34457, 1541

-

6.1.1.11

2'-dATP + L-serine + tRNASer = 2'-dAMP + diphosphate + L-seryl-tRNASer

0

-

6.1.1.11

dATP + L-serine + tRNASer = dAMP + diphosphate + L-seryl-tRNASer

0

-

6.1.1.11

2 entries

6.1.1.19

2'-deoxyadenosine 5'-triphosphate + L-arginine + tRNAArg = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-arginyl-tRNAArg

0

-

6.1.1.20

2'-deoxyadenosine 5'-triphosphate + L-phenylalanine + tRNAPhe = 2'-deoxyadenosine 5'-monophosphate + diphosphate + L-phenylalanyl-tRNAPhe

340, 0

-

6.1.1.21

dATP + L-histidine + tRNAHis = dAMP + diphosphate + L-histidyl-tRNAHis

0

-

6.1.1.4

2'-dATP + L-leucine + tRNALeu = 2'-dAMP + diphosphate + L-leucyl-tRNALeu

0

-

6.1.1.6

dATP + lysine + tRNALys = dAMP + L-lysyl-tRNALys + diphosphate

0

-

6.2.1.1

dATP + acetate + CoA = dAMP + diphosphate + acetyl-CoA

652101, 0, 563

-

6.2.1.20

dATP + a fatty acid + [acyl-carrier protein] = dAMP + diphosphate + fatty acid-[acyl-carrier protein]

0

-

6.2.1.22

dATP + acetate + citrate (pro-3S)-lyase = dAMP + diphosphate + citrate(pro-3S)-lyase

0

-

6.2.1.3

dATP + fatty acid + CoA = dAMP + diphosphate + acyl-CoA

0

-

6.2.1.7

dATP + cholate + CoA = dAMP + diphosphate + choloyl-CoA

0

-

6.3.1.5

dATP + deamido-NAD+ + NH3 = dAMP + diphosphate + NAD+

0

-

6.3.4.5

dATP + L-citrulline + L-Asp = dAMP + diphosphate + L-argininosuccinate

0

-

6.3.5.4

dATP + L-Asp + L-Gln = dAMP + diphosphate + Asn + Glu

0

-

6.3.5.4

dATP + L-Asp + NH3 = dAMP + diphosphate + Asn

0

-

6.5.1.1

dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)m+n

0, 651216, 653383

-

6.5.1.1

dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = dAMP + diphosphate + (deoxyribonucleotide)n+m

0

-

6.3.5.4

2 entries

6.5.1.1

2 entries

6.5.1.3

dATP + (ribonucleotide)n + (ribonucleotide)m = dAMP + phosphate + (ribonucleotide)n+m

0

-

Enzyme Cofactor/Cosubstrate (1 result)

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Show Cofactor (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.11.31

activation, can replace AMP or ADP

644959

-

Activator in Enzyme-catalyzed Reactions (6 results)

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Show Activating Compound (6 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.4.1.2

stimulation

391549

-

2.7.1.90

activation, about 25% as efficient as AMP

642075

-

3.5.4.1

10.0 mM, relative activity 154%

209489

-

3.5.4.12

0.025 mM: low activation

288999

-

3.5.4.12

at low substrate, dCMP, concentration: activation at higher concentration of either: inhibition

289002

-

3.5.4.12

competitive inhibitor, activates enzyme at low substrate concentration mimicing the cooperative effect of the substrate, dAMP activates dCMPase 4fold at low substrate concentration, no activating effect on the modified enzyme, glutaraldehyde-dCMPase

288998

-

3.5.4.12

3 entries

Inhibitor in Enzyme-catalyzed Reactions (27 results)

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Show Inhibitors (27 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.13.12.7

-

484853

-

2.4.2.7

-

638161

-

2.7.1.113

-

640562

-

2.7.1.74

not

641929, 641931

2qro, 3D-view

2.7.1.74

strong

641941

2qro, 3D-view

2.7.1.74

2 entries

2.7.1.76

0.2 mM, 36% inhibition

641974

-

2.7.4.13

competitive, dTMP as substrate

642542

-

2.7.4.8

10-15% inhibition at 5 mM

700079

-

2.7.4.9

5 mM, about 15% inhibition

692915

-

3.1.3.11

-

170750

-

3.1.3.11

-

170751

-

3.1.30.1

-

134970, 134971

4cxo, 3D-view

3.1.30.1

50% inhibition by 0.085 mM dAMP

134964

4cxo, 3D-view

3.1.3.11

2 entries

3.1.30.1

2 entries

3.1.30.2

competitive inhibitor of partial type, dAMP forming a complex with Sma nuc does not completely prevent the RNA binding and reduces the enzyme affinity to RNA substrate in competition with RNA for the binding site

730959

-

3.5.4.10

decreased IMP cyclohydrolase activity by 10-50%

172161

-

3.5.4.12

-

289018

-

3.5.4.12

at low substrate, dCMP, concentration: activation at higher concentration of either: competitive inhibition; competitive inhibitor, activates enzyme at low substrate concentration mimicing the cooperative effect of the substrate

289002

-

3.5.4.12

competitive inhibitor, activates enzyme at low substrate concentration mimicing the cooperative effect of the substrate

288998, 289003

-

3.5.4.12

kinetics of dAMP inhibition

289012

-

3.5.4.12

4 entries

3.6.1.9

16% inhibition at 17 mM

246831

-

4.1.1.23

-

693556

-

4.2.99.18

-

666478

-

4.3.2.2

-

1541

-

4.3.2.2

competitive

34457

-

4.3.2.2

2 entries

4.6.1.19

-

134494

-

4.6.1.20

-

24220

-

6.3.4.4

-

1548

-

3D Structure of Enzyme-Ligand-Complex (PDB) (6 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (6 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.7.1.74

2qro, 3D-view

2.7.7.7

5ihe, 3D-view

3.1.11.2

2ioc, 3D-view

3.1.3.5

2pau, 3D-view

3.1.30.1

4cxo, 3D-view

3.2.2.22

6loy, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (14 results)

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Show Turnover Number (14 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.4.2.6

0.0066

-

pH 7.5, 37°C, recombinant wild-type enzyme

674900

2.7.4.1

0.06

-

pH 8.0, 30°C

760249

2.7.4.1

0.6

-

pH 8.0, 30°C

760249

2.7.4.1

2.77

-

pH 8.0, 30°C

760249

2.7.4.4

80

-

isoform AMPK2, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C

722061

2.7.4.4

500

-

isoform AMPK1, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C

722061

3.1.3.5

0.3

-

+/- 0.01

656266

3.1.3.5

174

-

37°C, pH not specified in the publication

729593

3.1.3.89

0.06

-

mutant E122A, pH 7.5, 37°C

722956

3.1.3.89

0.08

-

mutant V30A, pH 7.5, 37°C

722956

3.1.3.89

0.13

-

mutant V37A, pH 7.5, 37°C

722956

3.1.3.89

0.14

-

wild-type, pH 7.5, 37°C

722956

3.1.3.89

0.3

-

presence of Co2+, pH 8.0, 37°C

656266

3.1.3.89

1

-

wild type enzyme, at pH 8.0 and 30°C

749824

2.7.4.1

3 entries

2.7.4.4

2 entries

3.1.3.5

2 entries

3.1.3.89

6 entries

K_M Value (29 results)

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Show KM Value (29 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.4.2.6

0.25

-

pH 7.5, 37°C, recombinant wild-type enzyme

674900

2.7.4.1

0.71

-

pH 8.0, 30°C

760249

2.7.4.1

1.03

-

pH 8.0, 30°C

760249

2.7.4.1

1.69

-

pH 8.0, 30°C

760249

2.7.4.1

3 entries

2.7.4.11

1

-

cosubstrate ATP

642684

2.7.4.13

0.22

-

pH 7.5, 37°C

642542

2.7.4.13

1.1

-

at 30°C, pH 8.0 and saturating Mg2+ and K+ concentrations

661371

2.7.4.3

0.507

-

recombinant adenylate kinase 4, using ATP as cosubstrate

704047

2.7.4.3

0.85

-

cosubstrate ATP, pH 7.4, 27°C

642585

2.7.4.3

2

-

Km above 2.0 mM, adenylate kinase 5 domain AK5p1, with ATP as phosphate donor

703721

2.7.4.4

0.08

-

isoform AMPK2, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C

722061

2.7.4.4

0.14

-

isoform AMPK1, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C

722061

2.7.4.13

2 entries

2.7.4.3

3 entries

2.7.4.4

2 entries

2.7.9.1

0.1

-

pH 6.8, 25ºC

645463

3.1.3.5

0.012

-

+/- 0.001

656266

3.1.3.5

0.035

-

-

95035

3.1.3.5

0.05

-

-

95037

3.1.3.5

0.077

-

-

95042

3.1.3.5

0.114

-

37°C, pH not specified in the publication

729593

3.1.3.5

0.125

-

-

95051

3.1.3.5

0.13

-

cytosolic enzyme c-N-I

95058

3.1.3.5

2

3

37°C, pH 7.0

663466

3.1.3.5

5.2

-

37°C, pH 7.0, presence of 1 mM ADP

663466

3.1.3.5

35

-

-

95045

3.1.3.89

0.012

-

presence of Co2+, pH 8.0, 37°C

656266

3.1.3.89

0.016

-

mutant V37A, pH 7.5, 37°C

722956

3.1.3.89

0.017

-

wild-type, pH 7.5, 37°C

722956

3.1.3.89

0.034

-

mutant E122A, pH 7.5, 37°C

722956

3.1.3.89

0.042

-

mutant V30A, pH 7.5, 37°C

722956

3.1.3.89

0.32

-

wild type enzyme, at pH 8.0 and 30°C

749824

3.1.3.5

10 entries

3.1.3.89

6 entries

K_i Value (8 results)

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Show KI Value (8 entries)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.13.12.7

0.9

-

-

484853

2.7.1.113

0.028

-

pH 7.6, 37°C, recombinant deoxyguanosine kinase

640562

2.7.4.13

0.15

-

dTMP as substrate, pH 7.6, 37°C

642542

3.1.30.1

0.085

-

-

134964

3.1.30.2

0.06

-

pH 8.5, 37°C

730959

4.1.1.23

7.4

-

-

693556

4.1.1.23

10

-

above 10 mM

693556

4.1.1.23

2 entries

4.2.99.18

0.165

-

pH 7.6, 37°C

666478

References & Links

Literature References (138)

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Show Reference (138 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

340

6754571

Phenylalanyl-tRNA synthetases from hen liver cytoplasm and mitochondria, yeast cytoplasm and mitochondria, and from Escherichia coli: substrate specificity relationship with regard to ATP analogs

1982

Gabius, H.J.; Freist, W.; Cramer, F.

Hoppe-Seyler's Z. Physiol. Chem.

363

1241-1246

563

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Fatty acyl-CoA synthetases

1974

Londesborough, J.C.; Webster, L.T.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

10

469-488

1541

468834

Specificity of adenylosuccinate synthetase and adenylosuccinate lyase from Leishmania donovani. Selective amination of an antiprotozoal agent

1979

Spector, T.; Jones, T.E.; Elion, G.B.

J. Biol. Chem.

254

8422-8426

1548

4436310

Human adenylosuccinate synthetase. Partial purification, kinetic and regulatory properties of the enzyme from placenta

1974

Van der Weyden, M.B.; Kelly, W.N.

J. Biol. Chem.

249

7282-7289

24220

7074019

Studies of catalysis by ribonuclease U2. Steady-state kinetics for transphosphorylation of oligonucleotide and synthetic substrates

1982

Yasuda, T.; Inoue, Y.

Biochemistry

21

364-369

34457

300632

Mammalian adenylosuccinate lyase. Participation in the conversion of 2 -dIMP and beta-D-arabinosyl-IMP to adenine nucleotides

1977

Spector, T.

Biochim. Biophys. Acta

481

741-745

94572

-

E. coli alkaline phosphatase

1971

Reid, T.W.; Wilson, I.B.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

4

373-415

94596

-

Purification and characterization of the outer membrane associated alkaline phosphatase of Lysobacter enzymogenes

1986

von Tigerstrom R.G.; Stelmaschuk, S.

J. Gen. Microbiol.

132

1379-1387

95021

-

Manganese-dependent production, and properties, of 5'-nucleotidase by alkalophilic Bacillus No. A-59

1989

Ikura, Y.; Horikoshi, K.

Agric. Biol. Chem.

53

645-649

95028

2822031

Purification, characterization and cellular localization of 5'-nucleotidase from Torpedo electric organ

1987

Grondal, E.J.M.; Zimmermann, H.

Biochem. J.

245

805-810

95033

-

Purification and properties of 5'-nucleotidase from cod muscle

1986

Yamamoto, H.; Tomioka, K.; Kawai, H.; Endo, K.

Agric. Biol. Chem.

50

1123-1129

95035

3001058

Human placental cytoplasmic 5'-nucleotidase. Kinetic properties and inhibition

1986

Madrid-Marina, V.; Fox, I.H.

J. Biol. Chem.

261

444-452

95037

2986711

Isolation and kinetic properties of 5'-nucleotidase from guinea-pig skeletal muscle

1985

Camici, M.; Fini, C.; Ipata, P.L.

Biochim. Biophys. Acta

840

6-12

95042

6271180

5'-Nucleotidase from rat heart

1981

Naito, Y.; Lowenstein, J.M.

Biochemistry

20

5188-5194

95045

6260203

Purification and some properties of cytosol 5'-nucleotidase from rat liver

1981

Itoh, R.

Biochim. Biophys. Acta

657

402-410

95051

-

A 5'-nucleotidase from Neurospora crassa

1974

Olson, A.C.; Fraser, M.J.

Biochim. Biophys. Acta

334

156-167

95054

-

Nucleotide phosphomonoesterases

1971

Drummond, G.I.; Yamamoto, M.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

4

337-354

95058

9636049

Nucleotide and nucleoside analogues as inhibitors of cytosolic 5'-nucleotidase I from heart

1998

Garvey, E.P.; Lowen, G.T.; Almond, M.R.

Biochemistry

37

9043-9051

95065

2344353

Partial purification and properties of an AMP-specific 5'-nucleotidase from pigeon heart

1990

Skladanowski, A.C.; Newby, A.C.

Biochem. J.

268

117-122

95067

8764609

A low-Km 5'-nucleotidase from rat brain cytosolic fraction: purification, kinetic properties, and description of regulation by a novel factor that increases sensitivity to inhibition by ATP and ADP

1996

Orford, M.R.; Saggerson, E.D.

J. Neurochem.

67

795-804

95074

9675234

Biochemical properties of 5'-nucleotidase from mouse skeletal muscle

1998

Martinez-Martinez, A.; Flores-Flores, C.; Campoy, F.J.; Munoz-Delgado, E.; Fini, C.; Vidal, C.J.

Biochim. Biophys. Acta

1386

16-28

114220

6272635

Studies on avian erythrocyte metabolism: purification and properties of myo-inositol 1-phosphatase from chick erythrocytes

1981

Roth, S.C.; Harkness, D.R.; Isaacks, R.E.

Arch. Biochem. Biophys.

210

465-473

134494

965365

Further studies on the specificity of the minor ribonuclease from Aspergillus saitoi

1976

Irie, M.; Ohgi, K.

J. Biochem.

80

39-43

134760

4552990

Purification and characterization of acid phosphatase V from Aspergillus nidulans

1972

Harsanyi, Z.; Dorn, G.L.

J. Bacteriol.

110

246-255

134765

5471255

Purification and properties of an acid phosphatase from bovine brain

1970

Chaimovich, H.; Nome, F.

Arch. Biochem. Biophys.

139

9-16

134964

171268

Specificity of the S1 nuclease from Aspergillus oryzae

1975

Wiegand, R.C.; Godson, G.N.; Radding, C.M.

J. Biol. Chem.

250

8848-8855

134970

6272646

S1 nuclease of Aspergillus oryzae: characterization of the associated phosphomonoesterase activity

1981

Oleson, A.E.; Hoganson, E.D.

Arch. Biochem. Biophys.

211

478-484

134971

-

Single-strand-specific nucleases

1982

Shishido, K.; Ando, T.

Cold Spring Harbor Monogr. Ser.

14

155-185

134994

6269630

Pisum sativum endonuclease. Studies on substrate specificity and possible use as a biochemical tool

1981

Wani, A.A.; Hart, R.W.

Biochim. Biophys. Acta

655

396-406

134996

620006

Purification and characterization of a DNA single strand specific endonuclease from human cells

1978

Wang, E.C.; Furth, J.J.; Rose, J.A.

Biochemistry

17

544-549

170750

232395

Purification and properties of a D-fructose 1,6-bisphosphatase from Saccharomyces cerevisiae

1979

Funayama, S.; Molano, J.; Gancedo, C.

Arch. Biochem. Biophys.

197

170-177

170751

221467

Purification and properties of fructose-1,6-bisphosphatase of Bacillus subtilis

1979

Fujita, Y.; Freese, E.

J. Biol. Chem.

254

5340-5349

172161

7947835

5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence and inhibitors

1994

Szabados, E.; Hindmarsh, E.J.; Phillips, L.; Duggleby, R.G.; Christopherson, R.I.

Biochemistry

33

14237-14245

172176

-

Purine, purine nucleoside, and purine nucleotide aminohydrolases

1971

Zielke, C.L.; Suelter, C.H.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

4

47-78

209489

-

Kinetic properties of cytosine deaminase from Serratia marcescens

1976

Yu, T.; Sakai, T.; Omata, S.

Agric. Biol. Chem.

40

543-549

209613

-

Adenosine aminohydrolase from Streptomyces aureofaciens

1978

Rosinova, M.; Zelinkova, E.; Zelinka, J.

Collect. Czech. Chem. Commun.

43

2324-2329

209672

13463021

5'-Adenylic acid deaminase. III. Properties and kinetic studies

1957

Lee, Y.

J. Biol. Chem.

227

999-1007

209680

39610

AMP deaminase from bakers yeast. Purification and some regulatory properties

1979

Yoshino, M.; Murakami, K.; Tsushima, K.

Biochim. Biophys. Acta

570

157-166

209715

-

Studies on ATP deaminase. IV. Distribution of ATP deaminase, and the purification and properties of acid-type ADP-deaminating enzyme

1967

Chung, S.T.; Aida, K.; Uemura, T.

J. Gen. Appl. Microbiol.

13

335-347

209854

6853543

T4 phage deoxyribonucleotide-synthesizing enzyme complex. Further studies on enzyme composition and regulation

1983

Allen, J.R.; Lasser, G.W.; Goldman, D.A.; Booth, J.W.; Mathews, C.K.

J. Biol. Chem.

258

5746-5753

209914

10620341

Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap3A and Ap4A, by two specific human dinucleoside polyphosphate hydrolases

2000

Guranowski, A.; Galbas, M.; Hartmann, R.; Justesen, J.

Arch. Biochem. Biophys.

373

218-224

210225

497237

Studies on a Ca2+-dependent nucleoside triphosphate pyrophosphohydrolase in rat liver plasma membranes

1979

Torp-Pedersen, C.; Flodgaard, H.; Saermark, T.

Biochim. Biophys. Acta

571

94-104

246706

5773435

A non-specific adenine nucleotide deaminase from Desulfovibrio desulfuricans

1969

Yates, M.G.

Biochim. Biophys. Acta

171

299-310

246716

-

Studies on ATP deaminase. II. Relationship between enzyme specificity and substrate structure

1967

Chung, S.T.; Aida, K.; Uemura, T.

J. Gen. Appl. Microbiol.

13

237-245

246717

6048966

Purification and properties of ATP deaminase from Microsporum audouini

1967

Chung, S.T.; Aida, K.

J. Biochem.

61

1-9

246831

4403504

The purification and properties of detergent-solubilized rat liver nucleotide pyrophosphatase

1972

Bachorik, P.S.; Dietrich, L.S.

J. Biol. Chem.

247

5071-5078

288998

101672

Freezing of dCMP aminohydrolase in the activated conformation by glutaraldehyde

1978

Nucci, R.; Raia, C.A.; Vaccaro, C.; Sepe, S.; Scarano, E.; Rossi, M.

J. Mol. Biol.

124

133-145

288999

7240207

Deoxycytidylate deaminase. Purification and some properties of the enzyme isolated from human spleen

1981

Ellims, P.H.; Kao, A.Y.; Chabner, B.A.

J. Biol. Chem.

256

6335-6340

289002

6662104

Analysis of competition for substrate sites in an allosteric enzyme with co-operative kinetics. Effects of dAMP and dUMP on donkey spleen deoxycytidylate aminohydrolase

1983

Mastrantonio, S.; Nucci, R.; Vaccaro, C.; Rossi, M.; Whitehead, E.P.

Eur. J. Biochem.

137

421-427

289003

7120402

Reversal of the effect of the allosteric ligands of dCMP-aminohydrolase and stabilization of the enzyme in the T form

1982

Raia, C.A.; Nucci, R.; Vaccaro, C.; Sepe, S.; Rella, R.

J. Mol. Biol.

157

557-570

289012

1898061

Allosteric modifier and substrate binding of donkey deoxycytidylate aminohydrolase (EC 3.5.4.12)

1991

Nucci, R.; Raia, C.A.; Vaccaro, C.; Rossi, M.; Whitehead, E.P.

Arch. Biochem. Biophys.

289

19-25

289018

8448179

Properties of an affinity-column-purified human deoxycytidylate deaminase

1993

Maley, G.F.; Lobo, A.P.; Maley, F.

Biochim. Biophys. Acta

1162

161-170

391549

1952936

The NAD-dependent glutamate dehydrogenase from Dictyostelium discoideum: purification and properties

1991

Pamula, F.; Wheldrake, J.F.

Arch. Biochem. Biophys.

291

225-230

393944

5139533

Purification and properties of adenylyl sulfate reductase from phototrophic sulfur bacterium, Thiocapsa roseopersicina

1971

Trueper, H.G.; Rogers, L.A.

J. Bacteriol.

108

1112-1121

484853

5480123

Substrate-binding properties of firefly luciferase. II. ATP-binding site

1970

Lee, R.T.; Denburg, J.L.; McElroy, W.D.

Arch. Biochem. Biophys.

141

38-52

638050

10419637

Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system

1999

Pistotnik, E.; Sakamoto, H.; Pochet, S.; Namane, A.; Barzu, O.

Anal. Biochem.

271

192-193

638161

20306

Purification and comparative study of adenine and guanine phosphoribosyltransferases from Schizosaccharomyces pombe

1977

Nagy, M.; Ribet, A.M.

Eur. J. Biochem.

77

77-85

640553

6295492

Deoxyguanosine kinase from human placenta

1982

Yamada, Y.; Goto, H.; Ogasawara, N.

Biochim. Biophys. Acta

709

265-272

640555

9463485

Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs

1998

Sjoberg, A.H.; Wang, L.; Eriksson, S.

Mol. Pharmacol.

53

270-273

640558

10455141

Cloning and characterization of mouse deoxyguanosine kinase. Evidence for a cytoplasmic isoform

1999

Petrakis, T.G.; Ktistaki, E.; Wang, L.; Eriksson, S.; Talianidis, I.

J. Biol. Chem.

274

24726-24730

640562

11181353

Antiviral guanosine analogs as substrates for deoxyguanosine kinase: implications for chemotherapy

2001

Herrstrom Sjoberg, A.; Wang, L.; Eriksson, S.

Antimicrob. Agents Chemother.

45

739-742

640566

8172906

Heterodimeric deoxynucleoside kinases of Lactobacillus acidophilus R-26: functional assignment of subunits using limited proteolysis controlled by end-product inhibitors

1994

Ikeda, S.; Ma, G.T.; Ives, D.H.

Biochemistry

33

5328-5334

640567

7896798

Cloning and expression of the heterodimeric deoxyguanosine kinase/deoxyadenosine kinase of Lactobacillus acidophilus R-26

1995

Ma, G.T.; Hong, Y.S.; Ives, D.H.

J. Biol. Chem.

270

6595-6601

641089

2986372

Purification and properties of adenosine kinase from rat liver: separation from deoxyadenosine kinase activity

1985

Drabikowska, A.K.; Halec, L.; Shugar, D.

Z. Naturforsch. C

40

34-41

641929

5687717

Properties of deoxycytidine kinase partially purified from L1210 cells

1968

Kessel, D.

J. Biol. Chem.

243

4739-4744

641931

5442271

Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme

1970

Durham, J.P.; Ives, D.H.

J. Biol. Chem.

245

2276-2284

641937

2163272

Selective inactivation of the deoxyadenosine phosphorylating activity of pure human deoxycytidine kinase: stabilization of different forms of the enzyme by substrates and biological detergents

1990

Kierdaszuk, B.; Eriksson, S.

Biochemistry

29

4109-4114

641941

2542307

Kinetic properties and inhibition of human T lymphoblast deoxycytidine kinase

1989

Datta, N.S.; Shewach, D.S.; Mitchell, B.S.; Fox, I.H.

J. Biol. Chem.

264

9359-9364

641950

199606

Deoxynucleoside kinases from Lactobacilli. Separate interacting sites for deoxycytidine and deoxyadenosine

1977

Deibler, R.D.; Reznik, R.B.; Ives, D.H.

J. Biol. Chem.

252

8240-8244

641974

5667299

The regulatory properties of deoxyadenosine kinase

1968

Krygier, V.; Momparler, R.L.

Biochim. Biophys. Acta

161

578-580

641976

4371811

The phosphorylation of ribavirin by deoxyadenosine kinase from rat liver. Differentiation between adenosine and deoxyadenosine kinase

1974

Streeter, D.G.; Simon, L.N.; Robins, R.K.; Miller, J.P.

Biochemistry

13

4543-4549

641977

199509

Purification and detection of deoxyribonucleoside kinases [proceedings]

1977

Baxter, A.; Carswell, L.M.; Durham, J.P.

Biochem. Soc. Trans.

5

979-981

641980

2851331

Amino-terminal nucleotide-binding sequences of a Lactobacillus deoxynucleoside kinase complex isolated by novel affinity chromatography

1988

Ikeda, S.; Swenson, R.P.; Ives, D.H.

Biochemistry

27

8648-8652

641981

5554289

Mammalian deoxynucleoside kinases. II. Deoxyadenosine kinase: purification and properties

1971

Krygier, V.; Momparler, R.L.

J. Biol. Chem.

246

2745-2751

641984

9213430

Modeling of purine nucleoside metabolism during mouse embryonic development. Relative routes of adenosine, deoxyadenosine, and deoxyguanosine metabolism

1996

Jenuth, J.P.; Mably, E.R.; Snyder, F.F.

Biochem. Cell Biol.

74

219-225

641987

9022297

Metabolism of adenosine and deoxyadenosine by human erythrocytes and CCRF-CEM leukemia cells

1996

Szabados, E.; Duggleby, R.G.; Christopherson, R.I.

Int. J. Biochem. Cell Biol.

28

1405-1414

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Links to other databases for 2'-deoxyadenosine 5'-monophosphate

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