Ligand (S)-3-hydroxybutyryl-CoA

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Basic Ligand Information

Molecular Structure
Picture of (S)-3-hydroxybutyryl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C25H42N7O18P3S
(S)-3-hydroxybutyryl-CoA
QHHKKMYHDBRONY-VKBDFPRVSA-N
Synonyms:
(3S)-3-hydroxybutanoyl-CoA, (3S)-3-hydroxybutyryl-CoA, (3S)-hydroxybutanoyl-CoA, (3S)-hydroxybutyryl-CoA, (S)-3-hydroxybutanoyl-CoA, a short-chain (3S)-3-hydroxyacyl-CoA, L-(+)-3-hydroxybutyryl-CoA, L-3-(OH)-butyryl-CoA, L-3-hydroxy-butyryl-CoA, L-3-hydroxybutyryl-CoA, L-beta-hydroxybutyryl-CoA, short-chain (3S)-3-hydroxyacyl-CoA


Show all pahtways known for Show all BRENDA pathways known for (S)-3-hydroxybutyryl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-3-hydroxybutyryl-CoA = crotonoyl-CoA + H2O
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutanoyl-CoA + NADP+
show the reaction diagram
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acetoacetyl-CoA + NADH = L-3-hydroxybutyryl-CoA + NAD+
show the reaction diagram
-
crotonyl-CoA + H2O = (S)-3-hydroxybutanoyl-CoA
show the reaction diagram
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-
2-hydroxy-2-methylpropanoyl-CoA = (S)-3-hydroxybutanoyl-CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-3-hydroxybutyryl-CoA + H2O = CoA + L-3-hydroxybutyrate
show the reaction diagram
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(S)-3-hydroxybutyryl-CoA = crotonyl-CoA + H2O
show the reaction diagram
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(S)-3-hydroxybutyryl-CoA = crotonoyl-CoA + H2O
show the reaction diagram

Product in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-acetoacetyl-CoA + NADPH + H+ = (S)-3-hydroxybutanoyl-CoA + NADP+
show the reaction diagram
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-
crotonyl-CoA + H2O = L-3-hydroxy-butyryl-CoA
show the reaction diagram
-
2-hydroxy-2-methylpropanoyl-CoA = (S)-3-hydroxybutanoyl-CoA
show the reaction diagram
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-
ATP + L-(+)-3-hydroxybutyrate + CoA = AMP + diphosphate + L-(+)-3-hydroxybutyryl-CoA
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive

3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (21 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
15
-
at pH 7.0 and 70°C

KM Value (26 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.022
-
-
0.075
-
pH 8.6, 65°C
0.06
-
at pH 7.0 and 70°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.037
-
pH 8, 25°C

References & Links

Links to other databases for (S)-3-hydroxybutyryl-CoA

ChEBI
PubChem
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PubChem