Ligand xanthurenic acid

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Basic Ligand Information

Molecular Structure
Picture of xanthurenic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H7NO4
xanthurenic acid
BZBKTWJIYTYFBH-YSJWDAEMSA-N
Synonyms:
4,8-dihydroxy-2-quinolinecarboxylic acid, xanthurenate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxykynurenine + glyoxylate = xanthurenic acid + glycine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-
3'-phosphoadenylyl sulfate + xanthurenic acid = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-hydroxykynurenine + glyoxylate = xanthurenic acid + glycine
show the reaction diagram
-
-
3-hydroxykynurenine + glyoxylate = xanthurenic acid + glycine
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
21% increase in pyridoxine 5-phosphate oxidase activity
-
triggers the hydrolysis of phosphoinositide by PI-PLC in gametocytes
-

Inhibitor in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.1 mM, 50.6% inhibition. 1 mM, 96.2% inhibition
-
48% inhibition at 2 mM and 13% inhibition at 0.2 mM
-
56% inhibition at 0.1 mM
-
weak inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.19
-
IC50: 0.19 mM
0.36
-
IC50: 0.36 mM

References & Links

Links to other databases for xanthurenic acid

ChEBI
PubChem
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PubChem