Ligand Tartronate

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Basic Ligand Information

Molecular Structure
Picture of Tartronate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H4O5
Tartronate
ROBFUDYVXSDBQM-UHFFFAOYSA-N
Synonyms:
2-Hydroxymalonate, 2-hydroxypropanedioic acid, Hydroxymalonate, Tartronic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxymalonate + NAD+ = oxomalonate + NADH
show the reaction diagram
-
2-hydroxymalonate = ?
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hydroxymalonate + NAD+ = oxomalonate + NADH
show the reaction diagram
-
hydroxymalonate + NAD+ = ? + NADH
show the reaction diagram
-
2-hydroxymalonate + NAD+ = oxomalonate + NADH + H+
show the reaction diagram
-
2-hydroxymalonate = ?
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
oxopropandioic acid + NADH + H+ = 2-hydroxypropanedioic acid + NAD+
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (29 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
slight inhibition of reverse reaction
-
inhibits only the cytosolic enzyme type with preference for hydroxypyruvate as substrate
-
dead-end inhibitor, competitive inhibitor versus L-lactate
-
competitive against L-serine, noncompetitive against NADP+
-
inhibition of oxidative decarboxylation of D-malate
-
i.e. ZINC901335
-
competitive inhibition
-
competitive inhibitor
-
competitive

3D Structure of Enzyme-Ligand-Complex (PDB) (13 results)

Enzyme Kinetic Parameters

Ki Value (6 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.5
-
-
1.8
-
pH 7.5, 25°C, recombinant wild-type enzyme

References & Links

Links to other databases for Tartronate

ChEBI
PubChem
ChEBI
PubChem