Ligand (R)-2-hydroxyglutaryl-1-CoA

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Basic Ligand Information

Molecular Structure
Picture of (R)-2-hydroxyglutaryl-1-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C26H42N7O20P3S
(R)-2-hydroxyglutaryl-1-CoA
ITRSBJZNLOYNNR-VKBDFPRVSA-N
Synonyms:
(R)-2-hydroxyglutaryl-CoA

Show all pahtways known for Show all BRENDA pathways known for (R)-2-hydroxyglutaryl-1-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + (R)-2-hydroxyglutarate = acetate + (R)-2-hydroxyglutaryl-CoA
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(R)-2-hydroxyglutaryl-CoA = (E)-glutaconyl-CoA + H2O
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(E)-glutaconyl-CoA + H2O = (R)-2-hydroxyglutaryl-CoA
show the reaction diagram
-
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
82
-
strictly anaerobic conditions, 25°C, Tris-HCl buffer, pH 8.0, (R)-2-hydroxyglutaryl-CoA dehydratase activator protein from Acidaminococcus fermentans

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.035
-
pH 7, 37°C, cosubstrate acetate

References & Links

Links to other databases for (R)-2-hydroxyglutaryl-1-CoA

ChEBI
PubChem
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PubChem