Ligand (1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate
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Basic Ligand Information
Molecular Structure

C8H8O6
(1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate
UKFMEOHAOCKDOL-YLWLKBPMSA-N
(1R,2S)-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate, (3S,4R)-3,4-Dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate, cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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(1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD+ = Protocatechuic acid + NADH + CO2
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cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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terephthalate + NADH + O2 + H+ = (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD+
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Substrate in Enzyme-catalyzed Reactions (2 results)
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(1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD+ = Protocatechuic acid + NADH + CO2
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cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,4-dicarboxylate + NAD+ = 3,4-dihydroxybenzoate + CO2 + NADH
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Product in Enzyme-catalyzed Reactions (2 results)
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terephthalate + NAD(P)H + O2 + H+ = (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD(P)+
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terephthalate + NADH + O2 + H+ = (1R,2S)-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate + NAD+
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Enzyme Kinetic Parameters
KM Value (1 result)
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References & Links
Literature References (3)
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Terephthalate 1,2-dioxygenase system from Comamonas testosteroni T-2: purification and some properties of the oxygenase component
1994
Schlaefli, H.R.; Weiss, M.A.; Leisinger, T.; Cook, A.M.
J. Bacteriol.
176
6644-6652
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Purification and some properties of (1R,2S)-1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase from Comamonas testosteroni T-2
1995
Saller, E.; Laune, H.; Oppenberg, H.R.S.; Cook, A.M.
FEMS Microbiol. Lett.
130
97-102
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Molecular analysis of isophthalate and terephthalate degradation by Comamonas testosteroni YZW-D.
1995
Wang, Y.Z.; Zhou, Y.; Zylstra, G.J.
Environ. Health Perspect.
103
9-12
Links to other databases for (1R,2S)-1,2-Dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate