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Ligand dTDP-beta-L-daunosamine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 6 H2 7 N3 O1 3 P2
dTDP-beta-L-daunosamine
CEQVCLWWGAYCPR-QUTCXQLSSA-N
Show all BRENDA pathways known for dTDP-beta-L-daunosamine
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (4 results)
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dTDP-beta-L-daunosamine + devancosaminyl-vancomycin = dTDP + ?
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dTDP-L-daunosamine + aklavinone = dTDP + ?
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rhodosaminyl aklavinone + dTDP-L-daunosamine = dTDP + daunosaminyl-rhodosaminyl-aklavinone
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dTDP-L-daunosamine + 4-O-(alpha-L-rhodosaminyl)aklavinone = dTDP + 4-O-[(4-O-alpha-L-daunosaminyl)-alpha-L-rhodosaminyl]aklavinone
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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2.13
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pH not specified in the publication, temperature not specified in the publication
KM Value (3 results)
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0.038
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pH not specified in the publication, temperature not specified in the publication
0.94
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in 75 mM Tris (pH 7.5), 12 mM MgCl2, at 25°C
0.94
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pH 7.5, 25°C, cosubstrate: rhodosaminyl aklavinone
References & Links Literature References (3)
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AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A
2004
Lu, W.; Leimkuhler, C.; Oberthür, M.; Kahne, D.; Walsh, C.T.
Biochemistry
43
4548-4558
Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A
2007
Leimkuhler, C.; Fridman, M.; Lupoli, T.; Walker, S.; Walsh, C.T.; Kahne, D.
J. Am. Chem. Soc.
129
10546-10550
A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases
2005
Oberthuer, M.; Leimkuhler, C.; Kruger, R.G.; Lu, W.; Walsh, C.T.; Kahne, D.
J. Am. Chem. Soc.
127
10747-10752
Links to other databases for dTDP-beta-L-daunosamine