Ligand Imidodiphosphate

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Basic Ligand Information

Molecular Structure
Picture of Imidodiphosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H5NO6P2
Imidodiphosphate
DINOPBPYOCMGGD-ZGFWTNSWSA-N
Synonyms:
imido-diphosphate, imido diphosphate, imidodiphosphonate, Imidodiphosphonic acid, imidodiphosphoric acid

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
beta, gamma-imido ATP + H2O = AMP + imido diphosphate
show the reaction diagram
-
adenosine 5’-[beta,gamma-imido]-triphosphate + L-Asp = AMP-Asp + imidodiphosphate
show the reaction diagram
-
-
Adenylyl beta,gamma-imido diphosphonate + L-leucine + tRNALeu = Adenylic acid + imido-diphosphate + L-leucyl-tRNALeu
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (22 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive to diphosphate
-
maximal inhibitory activity among diphosphate analogues, non-catalytic and catalytic conditions, inhibits the ATP-dependent helicase reaction but no effect on the ATP-independent duplex unwinding, structure of nucleic base and ribose fragment of NTP molecule have a slight effects on inhibitory properties
-
maximal inhibitory activity among diphosphate analogues, non-catalytic and catalytic conditions, inhibits the ATP-dependent helicase reaction but no effect on the ATP-independent duplex unwinding, structure of nucleic base and ribose fragment of NTP molecule have a slight effects on inhibitory properties
-
competitive with respect to diphosphate
-

3D Structure of Enzyme-Ligand-Complex (PDB) (44 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.014
-
pH 7.2, 25°C, wild-type enzyme

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.071
-
-

References & Links

Links to other databases for Imidodiphosphate

ChEBI
PubChem
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PubChem