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Ligand hexane

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Basic Ligand Information

Molecular Structure
Picture of hexane (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H14
hexane
VLKZOEOYAKHREP-UHFFFAOYSA-N
Synonyms:
GlcNAcbeta(1-4)Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphotetradecane, n-hexane

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (5 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
hexane + NADH + H+ + O2 = hexan-1-ol + NAD+ + H2O
show the reaction diagram
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hexane + NAD(P)H + O2 = 1-hexanol + 2-hexanol + NAD(P)+ + H2O
show the reaction diagram
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hexane + reduced ferreredoxin + O2 = hexan-2-ol + hexan-3-ol + oxidized ferredoxin + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphotetradecane = UDP + GlcNAcbeta(1-4)Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphotetradecane
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (29 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
significant increases in enzyme activity occurs after 25 h incubation at a concentration of 30%
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activity retention is highest in the presence of hexane, reaction shows maximum conversion and enantiomeric excess of 96 and more than 99%, respectively in 15%, v/v hexane with 2-propanol as the cosubstrate
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in asymmetric reduction by TeSADH in pure hexane, the organic solvent makes the process more efficient by allowing high concentrations of substrates to be used
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92.1% increase of activity at 80% (v/v)
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25%, activates to 106.13% of control
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enzyme activity is highest at concentrations of hexane between 5% and 30%
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enzyme activity is highest at concentrations of hexane between 5% and 30%
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102.21% activity at 20% (v/v)
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about 140% activity at 30% (v/v)
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the addition of n-hexane markedly enhances the esterification activities on all the medium- and long-chain saturated fatty acids
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53% activation of recombinant refolded enzyme at 10-30% v/v
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hydrolysis activity is enhanced in the presence of non-acceptor type organic solvents such as hexane, cyclohexane, diethyl ether, and acetone
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50%, 2fold higher activity compared to water as solvent
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enhances enzyme activity
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activates about 20% at 5-10% v/v, and 230% at 30% v/v
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activates slightly at 15% v/v
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1% (v/v), 1.1fold activation
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Inhibitor in Enzyme-catalyzed Reactions (25 results)

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EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
40% inhibition in buffer without NaCl, slight activation in buffer with 600 mM NaCl
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about 80% residual activity at 2% (v/v)
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enzyme activity is markedly reduced at concentrations of hexane below 5% and over 30%
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enzyme activity is markedly reduced at concentrations of hexane below 5% and over 30%
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0.1% (v/v)
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the cross-linked enzyme aggregate shows about 20% residual activity after incubation in hexane for about 24 h
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20%
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about 90% residual activity at 1 mM
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about 5% residual activity at 10% (w/v)
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76.9% residual activity at 5% (v/v)
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at 12.5% (v/v) remaining activity, 98.25%, and 25% (v/v) remaining activity, 92.22%
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3D Structure of Enzyme-Ligand-Complex (PDB) (8 results)

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Enzyme Kinetic Parameters

KM Value (1 result)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

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Links to other databases for hexane

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ChEBI
PubChem
ChEBI
PubChem