Ligand trifluoromethylthymidine

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Basic Ligand Information

Molecular Structure
Picture of trifluoromethylthymidine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H11F3N2O5
trifluoromethylthymidine
VSQQQLOSPVPRAZ-RRKCRQDMSA-N
Synonyms:
5-Trifluoromethyldeoxyuridine, 5-trifluorothymidine, trifluorothymidine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-trifluorothymidine + phosphate = 5-trifluorothymine + 2-deoxy-alpha-D-ribose 1-phosphate
show the reaction diagram
-
ATP + trifluoromethylthymidine = ADP + trifluoromethylthymidine 5’-phosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2'-deoxyuridine + 5-trifluorothymine = 5-trifluorothymidine + uracil
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive to thymidine
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
8.25
-
at pH 7.6 and 37°C
0.36
-
at pH 7.8 and 25°C

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.856
-
at pH 7.6 and 37°C
0.022
-
at pH 7.8 and 25°C

References & Links

Links to other databases for trifluoromethylthymidine

ChEBI
PubChem
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PubChem