Ligand 5-L-glutamyl-(+)-3-aminoisobutyric acid
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Basic Ligand Information
Molecular Structure

C9H16N2O5
5-L-glutamyl-(+)-3-aminoisobutyric acid
FFJJSWCEJRPJEI-GDVGLLTNSA-N
gamma-L-Glu-(R)-beta-amino-iso-butyrate, gamma-L-Glu-beta-amino-iso-butyrate, gamma-L-Glu-DL-beta-amino-iso-butyrate, L-gamma-glutamyl-(+)-3-aminoisobutyric acid
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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L-gamma-glutamyl-(+)-3-aminoisobutyric acid = ?
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5-L-glutamyl-(+)-3-aminoisobutyric acid = 5-oxoproline + (+)-3-aminoisobutyric acid
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Product in Enzyme-catalyzed Reactions (3 results)
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ATP + L-Glu + (R)-beta-amino-iso-butyrate = ADP + phosphate + gamma-L-Glu-(R)-beta-amino-iso-butyrate
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ATP + L-Glu + beta-amino-iso-butyrate = ADP + phosphate + gamma-L-Glu-beta-amino-iso-butyrate
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ATP + L-Glu + DL-beta-amino-iso-butyrate = ADP + phosphate + gamma-L-Glu-DL-beta-amino-iso-butyrate
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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0.21
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pH and temperature not specified in the publication
0.071
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pH and temperature not specified in the publication
KM Value (2 results)
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0.33
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pH and temperature not specified in the publication
0.33
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pH and temperature not specified in the publication
References & Links
Literature References (3)
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The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase
1999
Griffith, O.W.; Mulcahy, R.T.
Adv. Enzymol. Relat. Areas Mol. Biol.
73
209-267
Escherichia coli gamma-glutamylcysteine synthetase. Two active site metal ions affect substrate and inhibitor binding
2002
Kelly, B.S.; Antholine, W.E.; Griffith, O.W.
J. Biol. Chem.
277
50-58
Probing the specificity of gamma-glutamylamine cyclotransferase: an enzyme involved in the metabolism of transglutaminase-catalyzed protein crosslinks
2013
Bowser, T.E.; Trawick, M.L.
Amino Acids
44
143-150
Links to other databases for 5-L-glutamyl-(+)-3-aminoisobutyric acid