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Ligand thiouracil

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Basic Ligand Information

Molecular Structure

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C₄H₄N₂OS

thiouracil

ZEMGGZBWXRYJHK-UHFFFAOYSA-N

Synonyms:

2-Thiouracil

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (5 results)

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S-adenosyl-L-methionine + 2-thiouracil = S-adenosyl-L-homocysteine + thiouracil-2-S-methylether

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deoxyadenosine + 2-thiouracil = adenine + deoxy-2-thiouridine

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2-thiouracil + 5-phospho-alpha-D-ribose 1-diphosphate = 2-thio-5'-UMP + diphosphate

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2-thiouracil + H2O = ?

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2-thiouracil + D-ribose 5-phosphate = ?

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Product in Enzyme-catalyzed Reactions (1 result)

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2-thiocytosine + H2O = 2-thiouracil + NH3

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Activator in Enzyme-catalyzed Reactions (1 result)

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induces biosynthesis of enzyme

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Inhibitor in Enzyme-catalyzed Reactions (7 results)

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439714, 439715, 439716

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plus ferricyanide, strong inhibition

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1 mM, 96% inhibition

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weak

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strong

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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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Enzyme Kinetic Parameters

K_M Value (3 results)

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0.67

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References & Links

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Show Reference (16 entries)

Links to other databases for thiouracil

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ChEBI

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Release 2023.1 (January 2023)