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Basic Ligand Information
1 8H 2 2O 3
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (7 results)
2-hydroxyestrone + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + ?
catecholestrone + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + ?
2-hydroxyestrone + UDP-glucuronate = ?
2-hydroxyestrone + UDPglucuronate = 2-hydroxyestrone 2-O-glucuronide + UDP
UDP-D-glucuronate + 2-hydroxyestrone = UDP + 2-hydroxyestrone beta-D-glucuronoside
UDP-glucuronate + 2-hydroxyestrone = UDP + 2-hydroxyestrone beta-D-glucuronide
3'-phosphoadenylylsulfate + 2-hydroxyestrone = adenosine 3',5'-bisphosphate + estrone 2-sulfate
- Inhibitor in Enzyme-catalyzed Reactions (1 result)
reversible inhibition of recombinant soluble enzyme in dose dependent manner, IC50 in low micromolar range
- Enzyme Kinetic Parameters
M Value (11 results)
37°C, pH 8.0, mutant enzyme F93A
apparent Km for UGT1A3
apparent Km for UGT1A1
apparent Km on expressed UGT1A3, 2 mM UDP glucuronic acid
apparent Km on expressed UGT1A1, 2 mM UDP glucuronic acid
apparent Km on expressed UGT2B7Y, 2 mM UDP glucuronic acid
37°C, pH 8.0, mutant enzyme F93L
37°C, pH 8.0, wild-type enzyme
37°C, pH 8.0, mutant enzyme F90L References & Links
Links to other databases for 2-hydroxyestrone