Ligand 23,24-bisnorcholesta-4-ene-22-oic acid

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Basic Ligand Information

Molecular Structure
Picture of 23,24-bisnorcholesta-4-ene-22-oic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C22H32O3
23,24-bisnorcholesta-4-ene-22-oic acid
QETBTXOVEBTJQH-WAMTXRNCSA-N
Synonyms:
3-oxo-23,24-bisnorchol-4-en-22-oate, 3-oxo-23,24-bisnorchol-4-en-22-oic acid, 3-oxo-23,24-bisnorcholest-4-en-22-oic acid, 3-oxo-23,24-bisnorcholesta-4-ene-22-oate, 3-oxo-23,24-bisnorcholesta-4-ene-22-oic acid, 9alpha-hydroxy-3-oxo-23,24-bisnorcholest-4-en-22-oic acid

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
3-oxo-23,24-bisnorcholest-4-en-22-oic acid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 9alpha-hydroxy-3-oxo-23,24-bisnorcholest-4-en-22-oic acid + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
in 0.1 M potassium phosphate, pH 7.0, at 22°C
0.08
-
isoform KshA1, at pH 7.0 and 22°C
2.6
-
isoform KshA5, at pH 7.0 and 22°C
0.6
-
pH 7.0, 22°C
pH 7.0, 22°C, KshAB
0.08
-

KM Value (8 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
in 0.1 M potassium phosphate, pH 7.0, at 22°C
0.003
-
isoform KshA1, at pH 7.0 and 22°C
0.0022
-
isoform KshA5, at pH 7.0 and 22°C
0.0012
-
Km less than 0.01 mM, isoform KshA1, in 50mMTris-HCl buffer (pH 7.0), temperature not specified in the publication
0.01
-
Km less than 0.01 mM, isoform KshA5, in 50 mM Tris-HCl buffer (pH 7.0), temperature not specified in the publication
0.01
-
pH 7.0, 22°C
pH 7.0, 22°C, KshAB
0.003
-

Ki Value (1 result)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
pH 7.0, 22°C
0.11
-

References & Links

Links to other databases for 23,24-bisnorcholesta-4-ene-22-oic acid

ChEBI
PubChem
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PubChem