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Ligand (R)-4'-phosphopantothenate

Basic Ligand Information

Molecular Structure

Related pathways

Pathway Source

Pathways

BRENDA

coenzyme A metabolism, pantothenate biosynthesis

KEGG

beta-Alanine metabolism, Biosynthesis of cofactors, Pantothenate and CoA biosynthesis

MetaCyc

coenzyme A biosynthesis I (bacteria), coenzyme A biosynthesis II (eukaryotic), coenzyme A biosynthesis III (archaea), phosphopantothenate biosynthesis I, phosphopantothenate biosynthesis II, phosphopantothenate biosynthesis III (archaea), superpathway of coenzyme A biosynthesis III (mammals), taurine biosynthesis II more

Show all BRENDA pathways known for (R)-4'-phosphopantothenate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Natural Substrate (4 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.5

CTP + (R)-4'-phosphopantothenate + L-Cys = ?

4412

6AI9, 3D-view

6.3.2.5

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

691514, 648960, 674749

6AI9, 3D-view

6.3.2.51

ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

691514, 715382, 740672, 740675, 648959, 702284, 702454, 648958, 740570, 768437, 759707

-

6.3.2.51

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

740672

-

6.3.2.5

2 entries

6.3.2.51

2 entries

In Vivo Product in Enzyme-catalyzed Reactions (44 results)

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Show Natural Product (44 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

641393, -

2ZSA, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

641393, -

3AEZ, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

641393, -

3BF3, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

641393, -

5KPZ, 3D-view

2.7.1.33

40 entries

6.3.2.26

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

-

6.3.2.36

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

-

6.3.2.36

ATP + 4-phosphopantoate + beta-alanine = AMP + diphosphate + 4'-phosphopantothenate

-

-

6.3.2.36

2 entries

6.3.2.5

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine = CTP + (R)-4'-phosphopantothenate + L-cysteine

-

6AI9, 3D-view

Substrate in Enzyme-catalyzed Reactions (11 results)

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Show Substrate (11 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

6.3.2.5

ATP + (R)-4'-phosphopantothenate + 2-aminoethanethiol disulfide = ?

4406, 648952

6AI9, 3D-view

6.3.2.5

ATP + (R)-4'-phosphopantothenate + 2-methylcysteine = N-(phosphopantothenyl)-alpha-methylcysteine + ADP + phosphate

4406, 648952

6AI9, 3D-view

6.3.2.5

ATP + (R)-4'-phosphopantothenate + beta-mercaptoethylamine = phosphopantetheine + ADP + phosphate

4406, 648952

6AI9, 3D-view

6.3.2.5

ATP + (R)-4'-phosphopantothenate + cystine = (R)-4'-phosphopantothenoyl-L-cystine + ADP + phosphate

4406

6AI9, 3D-view

6.3.2.5

ATP + (R)-4'-phosphopantothenate + L-Cys = (R)-4'-phosphopantothenoyl-L-cysteine + ADP + phosphate

648952, 648953, 648959, 4406, 648954, 702454, 702284

6AI9, 3D-view

6.3.2.5

CTP + (R)-4'-phosphopantothenate + L-Cys = (R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate

4412, 4406, 648951, 648956, 648960, 702454, 702284

6AI9, 3D-view

6.3.2.5

CTP + (R)-4'-phosphopantothenate + L-Cys = ?

4412

6AI9, 3D-view

6.3.2.5

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

674749, 691514, 648960, 773555

6AI9, 3D-view

6.3.2.5

CTP + (R)-4'-phosphopantothenate + L-cystine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cystine

773555

6AI9, 3D-view

6.3.2.51

ATP + (R)-4'-phosphopantothenate + L-cysteine = AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

691514, 715382, 740672, 740675, 648959, 702284, 702454, 648958, 740570, 768437, 759707, 773555

-

6.3.2.51

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine

740672, 702284, 702454, 648958, 740570

-

6.3.2.5

9 entries

6.3.2.51

2 entries

Product in Enzyme-catalyzed Reactions (101 results)

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Show Product (101 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.169

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

-

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

dATP + (R)-pantothenate = dADP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

GTP + (R)-pantothenate = GDP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

polyphosphate(n) + (R)-pantothenate = polyphosphate(n-1) + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

UTP + (R)-pantothenate = UDP + (R)-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + pantothenate = ADP + (R)-4-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + 4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + 4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + 4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + 4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + pantothenate = ADP + 4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

pantothenate + ATP = 4'-phosphopantothenate + ADP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + ATP = 4'-phosphopantothenate + ADP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + ATP = 4'-phosphopantothenate + ADP

-

3BF3, 3D-view

2.7.1.33

pantothenate + ATP = 4'-phosphopantothenate + ADP

-

5KPZ, 3D-view

2.7.1.33

pantothenate + CTP = 4'-phosphopantothenate + CDP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + CTP = 4'-phosphopantothenate + CDP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + CTP = 4'-phosphopantothenate + CDP

-

3BF3, 3D-view

2.7.1.33

pantothenate + CTP = 4'-phosphopantothenate + CDP

-

5KPZ, 3D-view

2.7.1.33

pantothenate + dATP = 4'-phosphopantothenate + dADP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + dATP = 4'-phosphopantothenate + dADP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + dATP = 4'-phosphopantothenate + dADP

-

3BF3, 3D-view

2.7.1.33

pantothenate + dATP = 4'-phosphopantothenate + dADP

-

5KPZ, 3D-view

2.7.1.33

pantothenate + dCTP = 4'-phosphopantothenate + dCDP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + dCTP = 4'-phosphopantothenate + dCDP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + dCTP = 4'-phosphopantothenate + dCDP

-

3BF3, 3D-view

2.7.1.33

pantothenate + dCTP = 4'-phosphopantothenate + dCDP

-

5KPZ, 3D-view

2.7.1.33

pantothenate + dGTP = 4'-phosphopantothenate + dGDP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + dGTP = 4'-phosphopantothenate + dGDP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + dGTP = 4'-phosphopantothenate + dGDP

-

3BF3, 3D-view

2.7.1.33

pantothenate + dGTP = 4'-phosphopantothenate + dGDP

-

5KPZ, 3D-view

2.7.1.33

pantothenate + dTTP = 4'-phosphopantothenate + dTDP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + dTTP = 4'-phosphopantothenate + dTDP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + dTTP = 4'-phosphopantothenate + dTDP

-

3BF3, 3D-view

2.7.1.33

pantothenate + dTTP = 4'-phosphopantothenate + dTDP

-

5KPZ, 3D-view

2.7.1.33

pantothenate + UTP = 4'-phosphopantothenate + UDP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + UTP = 4'-phosphopantothenate + UDP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + UTP = 4'-phosphopantothenate + UDP

-

3BF3, 3D-view

2.7.1.33

pantothenate + UTP = 4'-phosphopantothenate + UDP

-

5KPZ, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

4406, 641390, 641391, 641392, 641388, 641389, 641393, 641387, -

2ZSA, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

4406, 641390, 641391, 641392, 641388, 641389, 641393, 641387, -

3AEZ, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

4406, 641390, 641391, 641392, 641388, 641389, 641393, 641387, -

3BF3, 3D-view

2.7.1.33

ATP + D-pantothenate = ADP + D-4'-phosphopantothenate

4406, 641390, 641391, 641392, 641388, 641389, 641393, 641387, -

5KPZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + D-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ATP + pantothenate = ADP + D-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ATP + pantothenate = ADP + D-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ATP + pantothenate = ADP + D-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

GTP + pantothenate = GDP + D-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

GTP + pantothenate = GDP + D-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

GTP + pantothenate = GDP + D-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

GTP + pantothenate = GDP + D-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

ITP + pantothenate = IDP + D-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

ITP + pantothenate = IDP + D-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

ITP + pantothenate = IDP + D-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

ITP + pantothenate = IDP + D-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

UTP + pantothenate = UDP + D-4'-phosphopantothenate

-

2ZSA, 3D-view

2.7.1.33

UTP + pantothenate = UDP + D-4'-phosphopantothenate

-

3AEZ, 3D-view

2.7.1.33

UTP + pantothenate = UDP + D-4'-phosphopantothenate

-

3BF3, 3D-view

2.7.1.33

UTP + pantothenate = UDP + D-4'-phosphopantothenate

-

5KPZ, 3D-view

2.7.1.33

pantothenate + ATP = phosphopantothenate + ADP

-

2ZSA, 3D-view

2.7.1.33

pantothenate + ATP = phosphopantothenate + ADP

-

3AEZ, 3D-view

2.7.1.33

pantothenate + ATP = phosphopantothenate + ADP

-

3BF3, 3D-view

2.7.1.33

pantothenate + ATP = phosphopantothenate + ADP

-

5KPZ, 3D-view

2.7.1.33

96 entries

6.3.2.26

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

-

6.3.2.36

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

-

-

6.3.2.36

ATP + 4-phosphopantoate + beta-alanine = AMP + diphosphate + 4'-phosphopantothenate

-

-

6.3.2.36

2 entries

6.3.2.5

CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine = CTP + (R)-4'-phosphopantothenate + L-cysteine

-

6AI9, 3D-view

Activator in Enzyme-catalyzed Reactions (1 result)

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Show Activating Compound (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

4.1.3.6

contains 3 mol of phosphopantothenate per mol of enzyme

33351

-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

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Show Inhibitors (4 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.33

-

641389

2ZSA, 3D-view

2.7.1.33

-

641389

3AEZ, 3D-view

2.7.1.33

-

641389

3BF3, 3D-view

2.7.1.33

-

641389

5KPZ, 3D-view

2.7.1.33

4 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (25 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (25 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.7.1.33

2ZSA, 3D-view

2.7.1.33

3AEZ, 3D-view

2.7.1.33

3BF3, 3D-view

2.7.1.33

5KPZ, 3D-view

2.7.1.33

2ZSA, 3D-view

2.7.1.33

3AEZ, 3D-view

2.7.1.33

3BF3, 3D-view

2.7.1.33

5KPZ, 3D-view

2.7.1.33

2ZSA, 3D-view

2.7.1.33

3AEZ, 3D-view

2.7.1.33

3BF3, 3D-view

2.7.1.33

5KPZ, 3D-view

2.7.1.33

2ZSA, 3D-view

2.7.1.33

3AEZ, 3D-view

2.7.1.33

3BF3, 3D-view

2.7.1.33

5KPZ, 3D-view

2.7.1.33

2ZSA, 3D-view

2.7.1.33

3AEZ, 3D-view

2.7.1.33

3BF3, 3D-view

2.7.1.33

5KPZ, 3D-view

2.7.1.33

2ZSA, 3D-view

2.7.1.33

3AEZ, 3D-view

2.7.1.33

3BF3, 3D-view

2.7.1.33

5KPZ, 3D-view

2.7.1.33

24 entries

6.3.2.5

6AI9, 3D-view

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

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Show Turnover Number (4 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

6.3.2.5

0.88

-

at pH 7.6 and 25°C

648960

6.3.2.51

0.53

-

with CTP as cosubstrate, at pH 7.6 and 37°C

702454

6.3.2.51

0.56

-

with ATP as cosubstrate, at pH 7.6 and 37°C

702454

6.3.2.51

2.9

-

at pH 7.6 and 37°C

702284

6.3.2.51

3 entries

K_M Value (9 results)

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Show KM Value (9 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.3.2.5

0.013

-

co-substrate ATP, pH 7.6, 37°C

702454

6.3.2.5

0.017

-

pH 7.6, 37°C

702284

6.3.2.5

0.057

-

co-substrate CTP, pH 7.6, 37°C

702454

6.3.2.5

0.071

0.083

37°C, pH 7.5

648952, 648954

6.3.2.5

0.29

-

at pH 7.6 and 25°C

648960

6.3.2.5

0.29

-

pH 7.6

648960

6.3.2.51

0.013

-

with ATP as cosubstrate, at pH 7.6 and 37°C

702454

6.3.2.51

0.017

-

at pH 7.6 and 37°C

702284

6.3.2.51

0.057

-

with CTP as cosubstrate, at pH 7.6 and 37°C

702454

6.3.2.5

6 entries

6.3.2.51

3 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.7.1.33

0.125

-

pH 6.5, 37°C

641389

References & Links

Literature References (30)

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Show Reference (30 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4406

13630913

The metabolism of pantothenic acid

1959

Brown, G.M.

J. Biol. Chem.

234

370-378

4412

-

Mechanism of coenzyme A biosynthesis by Sarcina lutea

1983

Nishimura, N.; Kakimoto, T.; Chibata, I.

J. Ferment. Technol.

61

95-99

33351

4504333

Citrate lyase: a pantothenate-containing enzyme

1972

Srere, P.A.; Boettger, B.; Brooks, G.C.

Proc. Natl. Acad. Sci. USA

69

1201-1202

641387

4337331

Purification and properties of D-pantothenate kinase from rat liver

1972

Abiko, Y.; Ashida, S.I.; Shimizu, M.

Biochim. Biophys. Acta

268

364-372

641388

8384834

Coenzyme A biosynthesis in plants: partial purification and characterization of pantothenate kinase from spinach

1993

Falk, K.L.; Guerra, D.J.

Arch. Biochem. Biophys.

301

424-430

641389

-

Purification and properties of pantothenate kinase from brevibacterium ammoniagenes IFO 12071

1973

Shimizu, S.; Kubo, K.; Tani, Y.; Ogata, K.

Agric. Biol. Chem.

37

2863-2870

641390

7084227

Regulation of the biosynthesis of CoA at the level of pantothenate kinase

1982

Halvorsen, O.; Skrede, S.

Eur. J. Biochem.

124

211-215

641391

2999132

The properties and regulation of pantothenate kinase from rat heart

1985

Fisher, M.N.; Robishaw, J.D.; Neely, J.R.

J. Biol. Chem.

260

15745-15751

641392

2995137

Regulation of pantothenate kinase from various tissues of the rat

1985

Fisher, M.N.; Neely, J.R.

FEBS Lett.

190

293-296

641393

3029083

Regulation of pantothenate kinase by coenzyme A and its thioesters

1987

Vallari, D.S.; Jackowski, S.; Rock, C.O.

J. Biol. Chem.

262

2468-2471

648951

440103

Synthesis of coenzyme A and its biosynthetic intermediates by microbial processes

1979

Shimizu, S.; Tani, Y.; Ogata, K.

Methods Enzymol.

62

236-245

648952

-

Pantothenic acid and coenzyme A: phosphopantothenoylcysteine synthetase from rat liver (pantothenate 4¦-phosphate: L-cysteine ligase, EC 6.3.2.5)

1976

Abiko, Y.

Methods Enzymol.

18A

350-354

648953

5707808

Further studies on phosphopantothenoylcysteine synthetase

1968

Abiko, Y.; Tomikawa, M.; Shimizu, M.

J. Biochem.

64

115-117

648954

6053309

Investigation on pantothenic acid and its related compounds

1967

Abiko, Y.

J. Biochem.

61

290-299

648956

-

A microbial synthesis of pantothenylalcohol 4¦-phosphate

1978

Shimizu, S.; Morioka, H.; Tani, Y.; Ogata, K.

Agric. Biol. Chem.

42

889-890

648958

14686929

Active-site residues and amino acid specificity of the bacterial 4'-phosphopantothenoylcysteine synthetase CoaB

2004

Kupke, T.

Eur. J. Biochem.

271

163-172

648959

12906824

Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution

2003

Manoj, N.; Strauss, E.; Begley, T.P.; Ealick, S.E.

Structure

11

927-936

648960

11278255

Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria

2001

Strauss, E.; Kinsland, C.; Ge, Y.; McLafferty, F.W.; Begley, T.P.

J. Biol. Chem.

276

13513-13516

674749

16371361

4-Phosphopantetheine biosynthesis in archaea

2006

Kupke, T.; Schwarz, W.

J. Biol. Chem.

281

5435-5444

691514

18759961

Drosophila phosphopantothenoylcysteine synthetase is required for tissue morphogenesis during oogenesis

2008

Bosveld, F.; Rana, A.; Lemstra, W.; Kampinga, H.H.; Sibon, O.C.

BMC Res. Notes

1

75

702284

19182993

Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis

2009

Yao, J.; Patrone, J.D.; Dotson, G.D.

Biochemistry

48

2799-2806

702454

19683078

Kinetic characterization of human phosphopantothenoylcysteine synthetase

2009

Yao, J.; Dotson, G.D.

Biochim. Biophys. Acta

1794

1743-1750

715382

21551303

Pantethine rescues phosphopantothenoylcysteine synthetase and phosphopantothenoylcysteine decarboxylase deficiency in Escherichia coli but not in Pseudomonas aeruginosa

2011

Balibar, C.J.; Hollis-Symynkywicz, M.F.; Tao, J.

J. Bacteriol.

193

3304-3312

740570

19902973

Selective inhibitors of bacterial phosphopantothenoylcysteine synthetase

2009

Patrone, J.D.; Yao, J.; Scott, N.E.; Dotson, G.D.

J. Am. Chem. Soc.

131

16340-16341

740672

11923312

Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics

2002

Daugherty, M.; Polanuyer, B.; Farrell, M.; Scholle, M.; Lykidis, A.; de Crecy-Lagard, V.; Osterman, A.

J. Biol. Chem.

277

21431-21439

740675

12860978

4-phosphopantetheine and coenzyme A biosynthesis in plants

2003

Kupke, T.; Hernandez-Acosta, P.; Culianez-Macia, F.A.

J. Biol. Chem.

278

38229-38237

759707

31337720

Identification of dephospho-coenzyme A (dephospho-CoA) kinase in Thermococcus kodakarensis and elucidation of the entire CoA biosynthesis pathway in Archaea

2019

Shimosaka, T.; Makarova, K.S.; Koonin, E.V.; Atomi, H.

mBio

10

e01146-19

759707

31337720

Identification of dephospho-coenzyme A (dephospho-CoA) kinase in Thermococcus kodakarensis and elucidation of the entire CoA biosynthesis pathway in Archaea

2019

Shimosaka, T.; Makarova, K.S.; Koonin, E.V.; Atomi, H.

mBio

10

e01146-19

759707

2 entries

768437

29754768

Mutations in PPCS, encoding phosphopantothenoylcysteine synthetase, cause autosomal-recessive dilated cardiomyopathy

2018

Iuso, A.; Wiersma, M.; Schueller, H.J.; Pode-Shakked, B.; Marek-Yagel, D.; Grigat, M.; Schwarzmayr, T.; Berutti, R.; Alhaddad, B.; Kanon, B.; Grzeschik, N.A.; Okun, J.G.; Perles, Z.; Salem, Y.; Barel, O.; Vardi, A.; Rubinshtein, M.; Tirosh, T.; Dubnov-Raz, G.; Messias, A.C.; Terrile, C.; Barshack, I.

Am. J. Hum. Genet.

102

1018-1030

773555

30653991

Crystallographic analysis of the catalytic mechanism of phosphopantothenoylcysteine synthetase from Saccharomyces cerevisiae

2019

Zheng, P.; Zhang, M.; Khan, M.H.; Liu, H.; Jin, Y.; Yue, J.; Gao, Y.; Teng, M.; Zhu, Z.; Niu, L.

J. Mol. Biol.

431

764-776

Links to other databases for (R)-4'-phosphopantothenate

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Show Links (1 entry)