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A silent ABC transporter isolated from Streptomyces rochei F20 induces multidrug resistance
1998
Fernandez-Moreno, M.A.; Carbo, L.; Cuesta, T.; Vallin, C.; Malpartida, F.
J. Bacteriol.
180
4017-4023
Influence of macrolides on guanosine diphospho-D-mannose dehydrogenase activity in Pseudomonas biofilm
2000
Mitsuya, Y.; Kawai, S.; Kobayashi, H.
J. Infect. Chemother.
6
45-50
Characterization of a plasmid-specified ribosome methylase associated with macrolide resistance
1981
Shivakumar, A.G.; Dubnau, D.
Nucleic Acids Res.
9
2549-2562
Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes
1966
Rychlik, I.
Biochim. Biophys. Acta
114
425-427
Structure of a phosphorylated derivative of oleandomycin, obtained by reaction of oleandomycin with an extract of an erythromycin-resistant strain of Escherichia coli
1988
O'Hara, K.; Kanda,T.; Kono, M.
J. Antibiot.
41
823-827
-
Purification of macrolide 2'-phosphotransferase from Streptomyces coelicolor Muller
1990
Marshall, V.P.; Coats, J.H.; Baczynskyj, L.; Cialdella, J.I.; Liggett, W.F.; McGee, J.E.
J. Ind. Microbiol.
6
295-298
Purification and characterization of macrolide 2'-phosphotransferase from a strain of Escherichia coli that is highly resistant to erythromycin
1989
O'Hara, K.; Kanda,T.; Ohmiya, K.; Ebisu, T.; Kono, M.
Antimicrob. Agents Chemother.
33
1354-1357
Appearance in Japan of highly macrolide-resistant Escherichia coli producing macrolide 2'-phosphotransferase II
1999
Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; Ishii, A.; O'Hara, K.; Sawai, T.
Microbios
97
137-144
Detection and characterization of macrolide 2'-phosphotransferase from a Pseudomonas aeruginosa clinical isolate
2000
Nakamura, A.; Miyakozawa, I.; Nakazawa, K.; O'Hara, K.; Sawai, T.
Antimicrob. Agents Chemother.
44
3241-3242
Human liver aldehyde oxidase: inhibition by 239 drugs
2004
Obach, R.S.; Huynh, P.; Allen, M.C.; Beedham, C.
J. Clin. Pharmacol.
44
7-19
The role of histidine residues conserved in the putative ATP-binding region of macrolide 2'-phosphotransferase II
2004
Taniguchi, K.; Nakamura, A.; Tsurubuchi, K.; O'Hara, K.; Sawai, T.
FEMS Microbiol. Lett.
232
123-126
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase
2002
Jones, A.; Elphick, H.; Pettitt, E.; Everard, M.L.; Evans, G.S.
Eur. Respir. J.
19
1136-1141
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis
2006
Voets, M.; Antes, I.; Scherer, C.; Mueller-Vieira, U.; Biemel, K.; Marchais-Oberwinkler, S.; Hartmann, R.W.
J. Med. Chem.
49
2222-2231
Activation of Bacterial Ribonuclease P by Macrolides
2008
Toumpeki, C.; Vourekas, A.; Kalavrizioti, D.; Stamatopoulou, V.; Drainas, D.
Biochemistry
47
4112 - 4118
Novel macrolide resistance module carried by the IncP-1beta resistance plasmid pRSB111, isolated from a wastewater treatment plant
2007
Szczepanowski, R.; Krahn, I.; Bohn, N.; Puehler, A.; Schlueter, A.
Antimicrob. Agents Chemother.
51
673-678
Erythromycin resistance-conferring plasmid pRSB105, isolated from a sewage treatment plant, harbors a new macrolide resistance determinant, an integron-containing Tn402-like element, and a large region of unknown function
2007
Schlueter, A.; Szczepanowski, R.; Kurz, N.; Schneiker, S.; Krahn, I.; Puehler, A.
Appl. Environ. Microbiol.
73
1952-1960
Targeting neutrophil elastase in cystic fibrosis
2008
Kelly, E.; Greene, C.M.; McElvaney, N.G.
Expert Opin. Ther. Targets
12
145-157
High-performance liquid chromatography determination of N- and O-demethylase activities of chemicals in human liver microsomes: application of postcolumn fluorescence derivatization using Nash reagent
2000
Kobayashi, K.; Yamamoto, T.; Taguchi, M.; Chiba, K.
Anal. Biochem.
284
342-347
The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance
2012
McCusker, K.P.; Fujimori, D.G.
ACS Chem. Biol.
7
64-72
Nucleotide selectivity of antibiotic kinases
2010
Shakya, T.; Wright, G.D.
Antimicrob. Agents Chemother.
54
1909-1913
Discovery of bile salt hydrolase inhibitors using an efficient high-throughput screening system
2014
Smith, K.; Zeng, X.; Lin, J.
PLoS ONE
9
e85344
Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine
1997
Zhang, H.; Coville, P.F.; Walker, R.J.; Miners, J.O.; Birkett, D.J.; Wanwimolruk, S.
Br. J. Clin. Pharmacol.
43
245-252
Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine
1997
Zhang, H.; Coville, P.F.; Walker, R.J.; Miners, J.O.; Birkett, D.J.; Wanwimolruk, S.
Br. J. Clin. Pharmacol.
43
245-252
Metabolic interactions of selected antimalarial and non-antimalarial drugs with the major pathway (3-hydroxylation) of quinine in human liver microsomes
1997
Zhao, X.J.; Ishizaki, T.
Br. J. Clin. Pharmacol.
44
505-511
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance A review of the past decade
2016
Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J.
Cancer Lett.
370
153-164
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance A review of the past decade
2016
Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J.
Cancer Lett.
370
153-164
ATP-binding cassette exporters structure and mechanism with a focus on P-glycoprotein and MRP1
2017
Arana, M.R.; Altenberg, G.
Curr. Med. Chem.
25
1-17
Characterization of bile salt hydrolase from Lactobacillus gasseri FR4 and demonstration of its substrate specificity and inhibitory mechanism using molecular docking analysis
2017
Rani, R.P.; Anandharaj, M.; Ravindran, A.D.
Front. Microbiol.
8
1004
Characterization of bile salt hydrolase from Lactobacillus gasseri FR4 and demonstration of its substrate specificity and inhibitory mechanism using molecular docking analysis
2017
Rani, R.P.; Anandharaj, M.; Ravindran, A.D.
Front. Microbiol.
8
1004
Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
2018
Nurkanto, A.; Jeelani, G.; Yamamoto, T.; Naito, Y.; Hishiki, T.; Mori, M.; Suematsu, M.; Shiomi, K.; Hashimoto, T.; Nozaki, T.
Int. J. Parasitol. Drugs Drug Resist.
8
125-136
Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
2018
Nurkanto, A.; Jeelani, G.; Yamamoto, T.; Naito, Y.; Hishiki, T.; Mori, M.; Suematsu, M.; Shiomi, K.; Hashimoto, T.; Nozaki, T.
Int. J. Parasitol. Drugs Drug Resist.
8
125-136
-
Disrupting Gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA
2018
Alexander, M.; Miu, A.; Oh, A.; Reichelt, M.; Ho, H.; Chalouni, C.; Labadie, S.; Wang, L.; Liang, J.; Nickerson, N.; Hu, H.; Yu, L.; Du, M.; Yan, D.; Park, S.; Kim, J.; Xu, M.; Sellers, B.; Purkey, H.; Skelton, N.; Koehler, M.; Payandeh, J.; Verma, V.; Xu, Y.; Koth, C.M.; Nishiyama, M.
Antimicrob. Agents Chemother.
62
e01142-18
An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity
2020
Debruycker, V.; Hutchin, A.; Masureel, M.; Ficici, E.; Martens, C.; Legrand, P.; Stein, R.A.; Mchaourab, H.S.; Faraldo-Gomez, J.D.; Remaut, H.; Govaerts, C.
Nat. Struct. Mol. Biol.
27
829-835