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BRENDA support

Ligand erythromycin A

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Basic Ligand Information

Molecular Structure
Picture of erythromycin A (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C37H67NO13
erythromycin A
ULGZDMOVFRHVEP-RWJQBGPGSA-N
Synonyms:
erythromycin, erythromycin[side 1], erythromycin[side 2]

Related pathways



Show all pahtways known for Show all BRENDA pathways known for erythromycin A

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + erythromycin = ADP + erythromycin-2'-O-phosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
erythromycin + [reduced NADPH-hemoprotein reductase] + O2 = ? + formaldehyde + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
erythromycin B + NADPH + H+ + O2 = erythromycin A + NADP+ + H2O
show the reaction diagram
-
-
S-adenosyl-L-methionine + erythromycin C = S-adenosyl-L-homocysteine + erythromycin A
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
enzyme synthesis induced by
-
crude cell extracts from cells treated with erythromycin show increased activity
-
significant stimulation of purified elastase
-

Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
potent dose-dependent inhibitory effect, inhibition of biofilm formation, PT-1578
-
potent inhibition of CYP11B2, recombinant enzyme
-
0.015 mM, 50% inhibition
-
acts as an alternate substrate neutrophil elastase inhibitor
-

3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.061
-
at pH 7.4 and 37°C
0.1313
-
recombinant enzyme, pH 6.0, 37°C

References & Links

Links to other databases for erythromycin A

EXTERNAL LINKS