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Ligand N-deacetylisoipecoside Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C2 5 H3 3 NO1 1
N-deacetylisoipecoside
MTAVTRZTGFLKSC-ONGZBVEHSA-N
(1S)-deacetylisoipecoside, 1alpha(S)-N-deacetylisoipecoside, 1alpha-(S)-N-deacetylisoipecoside, deacetylisoipecoside
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside = S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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dopamine + secologanin = (1S)-deacetylisoipecoside + H2O
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Substrate in Enzyme-catalyzed Reactions (3 results)
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S-adenosyl-L-methionine + N-deacetylisoipecoside = S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylipecoside
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S-adenosyl-L-methionine + 1alpha-(S)-N-deacetylisoipecoside = S-adenosyl-L-homocysteine + 6-O-methyl-N-deacetylisoipecoside
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1alpha(S)-N-deacetylisoipecoside + H2O = 1alpha(S)-N-deacetylisoipecoside aglycone + D-glucose
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Product in Enzyme-catalyzed Reactions (1 result)
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dopamine + secologanin = (1S)-deacetylisoipecoside + H2O
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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KM Value (2 results)
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References & Links Literature References (4)
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Enzymatic condensation of dopamine and secologanin by cell-free extracts of Alangium lamarckii
1997
DeEknamkul, W.; Ounaroon, A.; Tanahashi, T.; Kutchan, T.; Zenk, M.H.
Phytochemistry
45
477-484
The new beta-D-glucosidase in terpenoid-isoquinoline alkaloid biosynthesis in Psychotria ipecacuanha
2008
Nomura, T.; Quesada, A.L.; Kutchan, T.M.
J. Biol. Chem.
283
34650-34659
Three new O-methyltransferases are sufficient for all O-methylation reactions of ipecac alkaloid biosynthesis in root culture of Psychotria ipecacuanha
2010
Nomura, T.; Kutchan, T.M.
J. Biol. Chem.
285
7722-7738
Is a metabolic enzyme complex involved in the efficient and accurate control of Ipecac alkaloid biosynthesis in Psychotria ipecacuanha?
2010
Nomura, T.; Kutchan, T.M.
Plant Signal. Behav.
5
875-877
Links to other databases for N-deacetylisoipecoside