Ligand Galbeta(1-3)GalNAc

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Basic Ligand Information

Molecular Structure
Picture of Galbeta(1-3)GalNAc (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H25NO11
Galbeta(1-3)GalNAc
HMQPEDMEOBLSQB-UFLFEMAHSA-N
Synonyms:
beta-D-Gal-(1->3)-alpha-D-GalNAc, beta-D-Gal-(1->3)-beta-D-GalNAc, beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosamine, beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosmine, beta-D-galactose-1,3-N-acetyl-D-galactosamine, beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine, beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine, beta-D-galactosyl-1,3-N-acetyl-D-galactosamine, beta-D-galactosyl-1,3-N-acetylgalactosamine, beta-D-galactosyl-1,3-N-acetylgalactosylamide, beta D-galactosido-(1,3)-N-acetylgalactosamine, Gal-beta-(1->3)-GalNAc, Gal-beta-1,3-GalNAc, galacto-N-biose, Galbeta(1,3)GalNAc, Galbeta(1-3)4GalNAc, Galbeta(1->3)GalNAc, Galbeta1,3GalNAc, Galbeta1-3GalNAc

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
show the reaction diagram
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GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosamine
show the reaction diagram
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UDP-galactose + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine = UDP + beta-D-galactosyl-1,3-beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
show the reaction diagram
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GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine
show the reaction diagram
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CMP-N-acetylneuraminate + Galbeta(1->3)GalNAc = CMP + NeuAcalpha(2->6)Galbeta(1->3)GalNAc
show the reaction diagram
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CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc = CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
show the reaction diagram
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CMP-N-acetylneuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc = CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
UDP-galactose + N-acetyl-D-galactosamine = UDP + beta-D-galactosyl-1,3-N-acetyl-D-galactosamine
show the reaction diagram
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UDP-galactose + N-acetylgalactosamine = UDP + beta-D-galactosyl-1,3-N-acetylgalactosamine
show the reaction diagram
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alpha-D-galactose 1-phosphate + N-acetyl-galactosamine = beta-D-galactopyranosyl-1,3-N-acetyl-D-galactosmine + phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
the enzyme exhibits competitive inhibition between all kinds of acceptors; the enzyme exhibits noncompetitive inhibition between ganglioside GA1 and beta-D-Gal-(1->3)-beta-D-GalNAc or between ganglioside GA1 and [asialofeuin]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (9 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (29 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for Galbeta(1-3)GalNAc

ChEBI
PubChem
ChEBI
PubChem