Ligand S-adenosyl-L-ethionine

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Basic Ligand Information

Molecular Structure
Picture of S-adenosyl-L-ethionine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H24N6O5S
S-adenosyl-L-ethionine
UBQZUBPODLPCFG-PIBDHAAFSA-O
Synonyms:
S-adenosyl-(2S)-2-amino-4-(ethylsulfanyl)butanoic acid

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
S-adenosyl-L-ethionine + L-homocysteine = S-adenosyl-L-homocysteine + L-ethionine
-
show the reaction diagram
S-adenosyl-L-ethionine + 2-oxobutyrate = S-adenosyl-L-homocysteine + (3S)-methyl-2-oxovalerate
-
show the reaction diagram
S-adenosyl-L-ethionine + 1,4-diaminobutane = ?
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (11 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
0.6 mM
-
IC50: 0.05 mM
-
non-competitive inhibitor against DNA
-
irreversible, S-adenosyl-L-homocysteine and L-homocysteine prevent, but not DL-homocysteine, GSH, DTT or L-cysteine
-
70-98% inhibition at 1 mm
-
4 mM inhibits more than 50%
-
racemic mixture, 0.2 mM, 50% inhibition
-
2 mM
-

Enzyme Kinetic Parameters

IC50 Value (1 result)

COMMENTARY
EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
LITERATURE
IC50: 0.05 mM
0.05
-

References & Links

Links to other databases for S-adenosyl-L-ethionine

ChEBI
PubChem
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PubChem