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Ligand N-arachidonoylphosphatidylethanolamine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.54

N-arachidonoyl-phosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

708079

-

3.1.4.54

N-arachidonoylphosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

710454, 666213, 708079

-

3.1.4.54

2 entries

Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.4.4

N-arachidonoyl-phosphatidylethanolamine + H2O = phosphatidic acid + N-arachidonoylethanolamine

650338

-

3.1.4.54

N-arachidonoyl-phosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

708079

-

3.1.4.54

N-arachidonoylphosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidate

710098, 666213

-

3.1.4.54

N-arachidonoylphosphatidylethanolamine + H2O = N-arachidonoylethanolamine + phosphatidic acid

710454, 709610, 707099, 666213, 708079

-

3.1.4.54

3 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.4.54

0.04

-

pH 7.4, 37°C

707099

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

650338

11420181

Marked activation of the N-acylphosphatidylethanolamine-hydrolyzing phosphodiesterase by divalent cations

2001

Ueda, N.; Liu, Q.; Yamanaka, K.

Biochim. Biophys. Acta

1532

121-127

666213

15949819

N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: a novel enzyme of the beta-lactamase fold family releasing anandamide and other N-acylethanolamines

2005

Ueda, N.; Okamoto, Y.; Morishita, J.

Life Sci.

77

1750-1758

707099

15766717

Radiochromatographic assay of N-acyl-phosphatidylethanolamine-specific phospholipase D activity

2005

Fezza, F.; Gasperi, V.; Mazzei, C.; Maccarrone, M.

Anal. Biochem.

339

113-120

708079

17712822

Biosynthetic pathways of the endocannabinoid anandamide

2007

Okamoto, Y.; Wang, J.; Morishita, J.; Ueda, N.

Chem. Biodivers.

4

1842-1857

709610

15992380

Regional distribution and age-dependent expression of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat brain

2005

Morishita, J.; Okamoto, Y.; Tsuboi, K.; Ueno, M.; Sakamoto, H.; Maekawa, N.; Ueda N.

J. Neurochem.

94

753-762

710098

17655883

The stimulatory effect of phosphatidylethanolamine on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD)

2007

Wang, J.; Okamoto, Y.; Tsuboi, K.; Ueda, N.

Neuropharmacology

54

8-15

710454

19126434

Biology of endocannabinoid synthesis system

2009

Wang, J.; Ueda, N.

Prostaglandins Other Lipid Mediat.

89

112-119

Links to other databases for N-arachidonoylphosphatidylethanolamine

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Show Links (1 entry)