print visible entries

print all entries

Ligand Leu-Tyr

Basic Ligand Information

Molecular Structure

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.23

Leu-Tyr + H2O = Leu + Tyr

643878

-

Substrate in Enzyme-catalyzed Reactions (9 results)

top print hide

Show Substrate (9 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.1

L-Leu-L-Tyr + H2O = L-Leu + L-Tyr

651119

-

3.4.11.1

Leu-Tyr + H2O = Leu + Tyr

651057, 643878

-

3.4.11.1

2 entries

3.4.11.10

Leu-Tyr + H2O = Leu + Tyr

81176, 81179, 81181

-

3.4.11.16

Leu-Tyr + H2O = Leu + Tyr

643870

-

3.4.11.23

Leu-Tyr + H2O = Leu + Tyr

643878

-

3.4.22.6

L-Leu-L-Tyr + H2O = Leu + Tyr

81564

-

3.4.24.54

Leu-Tyr + H2O = ?

668856

-

3.4.24.54

Leu-Tyr + H2O = Leucine + tyrosine

31301

-

3.4.24.54

2 entries

3.5.1.13

L-Leu-L-Tyr + H2O = Leu + Tyr

208986

-

Product in Enzyme-catalyzed Reactions (8 results)

top print hide

Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.4.11.20

Leu-Leu-Tyr + H2O = Leu + Leu-Tyr

-

-

3.4.11.22

Gly-Leu-Tyr + H2O = Gly + Leu-Tyr

-

-

3.4.11.4

Gly-Leu-Tyr + H2O = Gly + Leu-Tyr

, 649359

-

3.4.14.1

Leu-Tyr-NH2 + H2O = Leu-Tyr + NH3

-

-

3.4.19.7

N-Formyl-Met-Leu-Tyr + H2O = N-Formyl-Met + Leu-Tyr

29061

-

3.4.22.15

Leu-Tyr-7-amido-4-methylcoumarin + H2O = Leu-Tyr + 7-amino-4-methylcoumarin

-

-

3.4.22.B20

Leu-Tyr-7-amido-4-methylcoumarin = Leu-Tyr + 7-amino-4-methylcoumarin

-

-

3.4.24.51

insulin B chain + H2O = Phe-Val-Asn + Gln + HLCGSH + LVEA + Leu-Tyr + LVCGERGFFYTPKA

-

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.4.15.1

-

708830

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (2 results)

top print hide

Show Turnover Number (2 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

3.4.11.1

351

-

pH 8.5, 37°C, wild-type enzyme

643878

3.4.11.10

85

-

-

81176, 81179

K_M Value (2 results)

top print hide

Show KM Value (2 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.4.11.1

1

-

pH 8.5, 37°C, wild-type enzyme

643878

3.4.11.10

1.5

-

-

81176, 81179

IC₅₀ Value (1 result)

top print hide

Show IC50 Value (1 entry)

EC NUMBER

IC50 VALUE

IC50 VALUE MAXIMUM

COMMENTARY

LITERATURE

3.4.15.1

0.0064

-

pH and temperature not specified in the publication

708830

References & Links

Literature References (14)

top print hide

Show Reference (14 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

29061

1547272

Isolation and purification of N-formylmethionine aminopeptidase from rat intestine

1992

Sherriff, R.M.; Broom, M.F.; Chadwick, V.S.

Biochim. Biophys. Acta

1119

275-280

31301

3904081

Characterization of mucrotoxin A from the venom of Trimeresurus mucrosquamatus (the Chinese habu snake)

1985

Kishida, M.; Nikai, T.; Mori, N.; Kohmura, S.; Sugihara, H.

Toxicon

23

637-645

81176

1012016

Aeromonas aminopeptidase

1976

Prescott, J.M.; Wilkes, S.H.

Methods Enzymol.

45

530-543

81179

5010066

Specificity of Aeromonas aminopeptidase toward amino acid amides and dipeptides

1972

Wagner, F.W.; Wilkes, S.H.; Prescott, J.M.

J. Biol. Chem.

247

1208-1210

81181

4961737

Aeromonas aminopeptidase: purification and some general properties

1966

Prescott, J.M.; Wilkes, S.H.

Arch. Biochem. Biophys.

117

328-336

81564

13888995

Chymopapain. I. Isolation, crystallization, and preliminary characterization

1962

Ebata, M.; Yasunobu, K.T.

J. Biol. Chem.

237

1086-1094

208986

4473253

The purification and properties of an amidohydrolase from soybean

1974

Hoagland, R.E.; Graf, G.

Can. J. Biochem.

52

903-910

643870

2890346

Proteins of the kidney microvillar membrane. Enzymic and molecular properties of aminopeptidase W

1987

Gee, N.S.; Kenny, A.J.

Biochem. J.

246

97-102

643878

10852868

Salmonella enterica serovar Typhimurium peptidase B is a leucyl aminopeptidase with specificity for acidic amino acids

2000

Mathew, Z.; Knox, T.M.; Miller, C.G.

J. Bacteriol.

182

3383-3393

649359

10653753

Purification and molecular characterization of a tripeptidase (PepT) from Lactobacillus helveticus

2000

Savijoki, K.; Palva, A.

Appl. Environ. Microbiol.

66

794-800

651057

10672029

Specificity of the wound-induced leucine aminopeptidase (LAP-A) of tomato. Activity on dipeptide and tripeptide substrates

2000

Gu, Y.Q.; Walling, L.L.

Eur. J. Biochem.

267

1178-1187

651119

11895433

Identification of residues critical for activity of the wound-induced leucine aminopeptidase (LAP-A) of tomato

2002

Gu, Y.Q.; Walling, L.L.

Eur. J. Biochem.

269

1630-1640

668856

-

Mucrolysin

2004

Komori, Y.; Nikai, T.

Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press

1

705-706

708830

19449887

Plant food-derived angiotensin I converting enzyme inhibitory peptides

2009

Guang, C.; Phillips, R.D.

J. Agric. Food Chem.

57

5113-5120

Links to other databases for Leu-Tyr

top print hide

Show Links (1 entry)

ChEBI

PubChem