Ligand D-mannonate

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Basic Ligand Information

Molecular Structure
Picture of D-mannonate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12O7
D-mannonate
RGHNJXZEOKUKBD-MBMOQRBOSA-N
Synonyms:
D-mannonic acid, mannonate


Show all pahtways known for Show all BRENDA pathways known for D-mannonate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
D-mannonate + NAD+ = D-fructuronate + NADH
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
PROVEN IN VIVO REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
D-mannuronate + NADPH = D-mannonate + NADP+
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Substrate in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
D-mannonate + NADH + H+ = ?
-
show the reaction diagram
D-mannonic acid + NAD+ = ?
-
show the reaction diagram
D-mannonate = ?
-
show the reaction diagram
D-mannonate = 2-dehydro-3-deoxy-D-mannonate + H2O
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
D-mannuronate + NADPH = D-mannonate + NADP+
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
non-competitive
-
inhibitory for forward and reverse reaction
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3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (12 results)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
at pH 7.9 and 25°C
0.53
-
mutant E185D, pH 7.5, 37°C
0.23
-
mutant E185G, pH 7.5, 37°C
0.94
-
mutant E186D, pH 7.5, 37°C
0.29
-
mutant E186G, pH 7.5, 37°C
1.1
-
mutant enzyme H311A, at pH 7.5 and 37°C
0.09
-
mutant H32G, pH 7.5, 37°C
1.29
-
mutant N103A/D109A, pH 7.5, 37°C
0.1
-
mutant N36G, pH 7.5, 37°C
1.4
-
pH 7.9, 25°C
1.6
-
wild type enzyme, at pH 7.5 and 37°C
5.88
-
wild-type, pH 7.5, 37°C
0.81
-

KM Value (15 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
at pH 7.9 and 25°C
14
-
mutant E185D, pH 7.5, 37°C
2.31
-
mutant E185G, pH 7.5, 37°C
4.55
-
mutant E186D, pH 7.5, 37°C
3.6
-
mutant E186G, pH 7.5, 37°C
5.3
-
mutant enzyme H311A, at pH 7.5 and 37°C
1.9
-
mutant H32G, pH 7.5, 37°C
5.21
-
mutant N103A/D109A, pH 7.5, 37°C
4.08
-
mutant N36G, pH 7.5, 37°C
4.67
-
wild type enzyme, at pH 7.5
3
-
wild-type, pH 7.5, 37°C
4.79
-

References & Links

Links to other databases for D-mannonate

ChEBI
PubChem
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PubChem