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Ligand 1,3,7-trimethyluric acid Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C8 H1 0 N4 O3
1,3,7-trimethyluric acid
BYXCFUMGEBZDDI-UHFFFAOYSA-N
1,3,7-trimethylurate, trimethyl uric acid
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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1,3,7-trimethylurate + NADH + H+ + O2 = 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol
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Substrate in Enzyme-catalyzed Reactions (1 result)
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1,3,7-trimethylurate + NADH + H+ + O2 = 1,3,7-trimethyl-5-hydroxyisourate + NAD+ + H2O
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Product in Enzyme-catalyzed Reactions (2 results)
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caffeine + ubiquinone + H2O = 1,3,7-trimethylurate + ubiquinol
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caffeine + ubiquinone-0 = trimethyl uric acid + ubiquinol-0
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (1 result)
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IC50 Value (2 results)
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0.067
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pH 8.0, Gln-dependent CTP formation
0.07
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pH 8.0, NH3-dependent CTP formation
References & Links Literature References (3)
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Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids
2010
Roy, A.C.; Lunn, F.A.; Bearne, S.L.
Bioorg. Med. Chem. Lett.
20
141-144
Delineation of the caffeine C-8 oxidation pathway in Pseudomonas sp. strain CBB1 via characterization of a new trimethyluric acid monooxygenase and genes involved in trimethyluric acid metabolism
2012
Mohanty, S.K.; Yu, C.L.; Das, S.; Louie, T.M.; Gakhar, L.; Subramanian, M.
J. Bacteriol.
194
3872-3882
Genetic characterization of caffeine degradation by bacteria and its potential applications
2015
Summers, R.; Mohanty, S.; Gopishetty, S.; Subramanian, M.
Microb. Biotechnol.
8
369-378
Links to other databases for 1,3,7-trimethyluric acid