Ligand Acetohydroxamic acid

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Basic Ligand Information

Molecular Structure
Picture of Acetohydroxamic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C2H5NO2
Acetohydroxamic acid
MLYYVTUWGNIJIB-BXKDBHETSA-N
Synonyms:
Acethydroxamic acid, aceto-hydroxamic acid, Acetohydroxamate, acetyl hydroxamate, acetylhydroxamic acid, hydroxamic acid, N-acetylhydroxylamine, N-hydroxyacetamide

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetohydroxamate + H2O = hydroxylamine + acetate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetohydroxamate + H2O = hydroxylamine + acetate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + hydroxylamine = CoA + N-acetylhydroxylamine
show the reaction diagram
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-
N-carbobenzoxy-L-glutaminylglycine + NH2OH = hydroxamic acid + ?
show the reaction diagram
-
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acetyl phosphate + hydroxylamine = acetyl hydroxamate + phosphate
show the reaction diagram
-
-
acetamide + hydroxylamine = acetylhydroxamic acid + NH3
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (60 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
inhibits only the cytosolic enzyme type with preference for glyoxylate as substrate
-
competitive vs. tetrahydrobiopterin, most probably due to chelation of enzyme's iron
-
inhibition of Co2+-MT1-MMP
-
slight inhibition
-
i.e. Lithostat
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3D Structure of Enzyme-Ligand-Complex (PDB) (164 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
14
-
hydrolysis

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.7
-
-
0.77
-
competitive

IC50 Value (9 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
1
-
above, pH not specified in the publication, temperature not specified in the publication

References & Links

Links to other databases for Acetohydroxamic acid

ChEBI
PubChem
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PubChem