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Ligand 4-hydroxyquinolin-2(1H)-one Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C9 H7 NO2
4-hydroxyquinolin-2(1H)-one
HDHQZCHIXUUSMK-UHFFFAOYSA-N
2,4-dihydroxyquinoline, 4-hydroxy-2(1H)-quinolone, 4-hydroxy-2-quinolone
Show all BRENDA pathways known for 4-hydroxyquinolin-2(1H)-one
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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malonyl-CoA + 2-aminobenzoyl-CoA = 2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
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Substrate in Enzyme-catalyzed Reactions (4 results)
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4-hydroxyquinolin-2(1H)-one + 3-methoxy-1,2-benzenediol = 8,9-dihydroxy-10-methoxy[1]benzofuro[3,2-c]quinolin-6(5H)-one
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4-hydroxyquinolin-2(1H)-one + 3-methyl-1,2-benzenediol = 8,9-dihydroxy-10-methyl[1]benzofuro[3,2-c]quinolin-6(5H)-one
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4-hydroxyquinolin-2(1H)-one + benzenediol = 8,9-dihydroxy[1]benzofuro[3,2-c]quinolin-6(5H)-one
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S-adenosyl-L-methionine + 4-hydroxyquinolin-2(1H)-one = S-adenosyl-L-homocysteine + 4-methoxyquinolin-2(1H)-one
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Product in Enzyme-catalyzed Reactions (3 results)
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malonyl-CoA + 2-aminobenzoyl-CoA = 2 CoA + 4-hydroxy-2(1H)-quinolone + CO2
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malonyl-[acyl-carrier protein] + 2-aminobenzoyl-CoA = CoA + acyl-carrier protein + 4-hydroxy-2(1H)-quinolone + CO2
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anthraniloyl-CoA + malonyl-CoA = 2,4-dihydroxyquinoline + 2 CoA + CO2 + ?
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Enzyme Kinetic Parameters
References & Links Literature References (2)
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The laccase-catalyzed domino reaction between catechols and heterocyclic 1,3-dicarbonyls and the unambiguous structure elucidation of the products by NMR spectroscopy and X-ray crystal structure analysis
2009
Hajdok, S.; Conrad, J.; Leutbecher, H.; Strobel, S.; Schleid, T.; Beifuss, U.
J. Org. Chem.
74
7230-7237
Modification of the Pseudomonasxa0aeruginosa toxin 2-heptyl-1-hydroxyquinolin-4(1H)-one and other secondary metabolites by methyltransferases from mycobacteria
2020
Sartor, P.; Bock, J.; Hennecke, U.; Thierbach, S.; Fetzner, S.
FEBS J.
FEHLT
0000
Links to other databases for 4-hydroxyquinolin-2(1H)-one